Navigation Links
Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
Date:1/22/2013

below the cellular level to discover why some people develop cancer, the search often involves tracing a chain of events to try to understand cause and effect of the behavior between several genes and the proteins which they express. In order to understand these complex pathways, researchers often turn levels of proteins on or off by expressing one gene or suppressing another. Part of a researcher's challenge is determining what the function of each component of a pathway is.

The cell employs a complex mechanism to protect genetic information and ensure that damaged DNA is not passed on to daughter cells. Cells have built in checkpoints and fail safes to ensure the accuracy of their DNA code and are able to slow or stop their own proliferation if the information is compromised. Loss of these checkpoints and the accumulation of damaged DNA often leads to cancer.

The Pathway

BRCA1 is a well-established tumor suppressor gene. Women who carry mutations in this gene have a high risk of developing breast and ovarian cancer. Tumors that arise often lack expression of three receptors: estrogen, progesterone and HER2 (thus, "triple-negative"), and do not respond to hormone therapy.

BRCA1 is important because it is involved in repairing DNA double-strand breaks, a kind of DNA damage that is especially dangerous for the integrity of our genome. BRCA1 also is involved in cell-cycle checkpoints after damage, which are control mechanisms during cell proliferation that make sure the DNA information has been accurately replicated and transferred to the daughter cells. Thus, BRCA1 is considered a safeguard of the genome.

Loss of BRCA1 is bad news for the information contained in a cell's genetic blueprint. It results in genomic instability characterized by unrepaired DNA breaks and chromosomal aberrations that compromise cell viability. How BRCA1-mutated cells are able to form tumors has been a long-standing question. Investigators rec
'/>"/>

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
2. Vitamin D supplements may protect against viral infections during the winter
3. Vitamin D for pregnant women and babies -- how much is enough?
4. Collaborative research team identifies safe upper level for vitamin A consumption for puppies
5. Health benefits of vitamin D dependent on type taken
6. Vitamin D with calcium shown to reduce mortality in elderly
7. 15th Vitamin D Workshop begins tomorrow
8. Link between vitamin C and twins can increase seed production in crops
9. Low vitamin D levels linked to weight gain in some older women
10. Obesity plus low vitamin D may add up to a greater risk of diabetes
11. Scientists confirm existence of vitamin deserts in the ocean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... described by the Volunteer Wildfire Services of South Africa ... government warned residents in certain parts of the province ... A high veld fire danger rating is expected ... the Great Kei and Mnquma area. Strong winds ... The thunderstorms bring lightning strikes and subsequent fire and ...
(Date:8/27/2014)... . , Charcot-Marie-Tooth ... affecting the peripheral nervous system. Researchers from the Department ... Medicine and University Medical Centre Gttingen have discovered that ... with the disease. These cells enwrap the nerve fibres ... the rapid transfer of electrical impulses. If Schwann cells ...
(Date:8/27/2014)... New evidence puts into doubt the long-standing belief that ... the brain plays a central role in depression. ... report that mice lacking the ability to make serotonin ... by conventional wisdom) did not show depression-like symptoms. ... Dingell VA Medical Center and Wayne State University School ...
Breaking Biology News(10 mins):Potential therapy for incurable Charcot-Marie-Tooth disease 2New study throws into question long-held belief about depression 2
... University of New Mexico (UNM), Brown University, and House Ear ... simplex virus type 1 (HSV1) infections growing inside cells. HSV1, ... latent form inside nerve cells. Re-activation and growth of HSV1 ... are published in the March 31 issue of PLoS ...
... United States in late 2004, many producers feared devastating yield ... world. In response to this threat, researchers have been evaluating ... a recent report in Crop Science identifies some ... which of the soybean germplasm accessions were resistant in the ...
... , HELSINKICould "interventions" bring children closer to nature? Researchers ... HortTechnology compares urban and rural children,s relationships ... children. In Finland, a country famous for its ... Department of Agricultural Sciences at the University of Helsinki ...
Cached Biology News:Researchers link herpes to Alzheimer's disease 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 3Researchers say children need horticultural interventions 2
(Date:8/27/2014)... , Aug. 27, 2014 Rhythm, a ... and genetic deficiencies that result in metabolic disorders, announced ... Form S-1 with the U.S. Securities and Exchange Commission ... shares of its common stock. The number of shares ... offering have not yet been determined. Citigroup ...
(Date:8/27/2014)... One of nature,s mysteries is how plants survive ... in the sun,s rays, while using this energy ... proteins in the plant,s blades quickly dissipate the ... protein quakes. Researchers at DTU Physics have now ... plants, algae and bacteria contain light-absorbing proteins which ...
(Date:8/27/2014)... , Aug. 27, 2014  Lisa Kulik saw fireworks ... July 4 holiday, thanks to a groundbreaking retinal implant ... internationally renowned clinician-researcher at the University of Southern California ... Peoria, Ariz. resident who has ... victims of sight. On June 2, she became the ...
(Date:8/27/2014)... 2014 Reportbuyer.com has added a new ... - A Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... A similar amount of hype currently surrounds ... microelectronics to water treatment, but is graphene the ... the Graphene Opportunity Report, authored by Tim ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2DTU researchers film protein quake for the first time 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... ... woman found dead four days after receiving the Gardasil vaccine has filed an ... been asked to bar lawsuits against manufacturers of defectively designed vaccines. The ... have a lessened incentive to produce a safe vaccine and public trust in ...
... ... ... 16, 2010 -- The American Medical Writers Association named medical writer, Rita Buckley, Writer/Owner ... for Excellence in Medical Communication. She received the awards for The Lehman Series Expert ...
... IRVINE, California and KARLSRUHE, Germany , June 16, 2010 ... Germany and the US. "Growth requires space" had already been the motto of,the ... , ... joimax(R) Inc. is moving from Campbell to Irvine, California , one,of ...
Cached Biology Technology:Supreme Court Amicus Brief Filed Opposing Lawsuit Protection for Manufacturers of Defectively Designed Vaccines 2Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 2Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 3joimax(R) Moves Into Larger Premises 2
RABBIT ANTI HUMAN CHYMOTRYPSIN...
... Captivate magnetic separator for ... used in conjunction with the ... C-21476) or other magnetic particles ... mL microcentrifuge tubes. Cell Biology ...
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
... • This book describes the basic ... preparing samples for protein transfer and ... bioluminescence-enhanced detection systems are also included. ... and characterization of glycoprotein carbohydrate chains ...
Biology Products: