Navigation Links
Vitamin D and calcium influence cell death in the colon, researchers find
Date:4/13/2008

Researchers at Emory University are learning how vitamins and minerals in the diet can stimulate or prevent the appearance of colon cancer.

Emory investigators will present their findings on biological markers that could influence colon cancer risk in three abstracts at the American Association for Cancer Research meeting in San Diego.

In a clinical study of 92 patients, supplementing diet with calcium and vitamin D appeared to increase the levels of a protein called Bax that controls programmed cell death in the colon. More Bax might be pushing pre-cancerous cells into programmed cell death, says Emory researcher Veronika Fedirko, who will present her team's results (abstract 464).

Previous studies have shown that calcium and vitamin D tend to reduce colon cancer risk.

"We were pleased that the effects of calcium and vitamin D were visible enough in this small study to be significant and reportable," Fedirko says. "We will have to fully evaluate each marker's strength as we accumulate more data."

The studies of colorectal biopsy samples are part of a larger effort to identify a portfolio of measurements that together can gauge someone's risk of getting colon cancer, says Roberd Bostick, MD, MPH, professor of epidemiology at Emory's Rollins School of Public Health.

"We want to have the equivalent of measuring cholesterol or high blood pressure, but for colon cancer instead of heart disease," Bostick says. "These measurements will describe the climate of risk in the colon rather than spotting individual tumors or cells that may become tumors."

More about Bostick's plans for developing non-invasive blood or urine tests for colon cancer risk is available in an Emory Health Sciences Magazine article: http://whsc.emory.edu/_pubs/hsc/winter08/pdf/hold_out_your_finger.pdf

Another abstract from Bostick and his colleagues (565) demonstrates in a 200-patient case-control study that high levels of calcium and vitamin D together are associated with increased levels of E-cadherin, which moderates colon cells' movement and proliferation.

A third abstract on the same case-control study (5504) shows that high levels of iron in the diet are linked to low levels of APC, a protein whose absence in colon cancer cells leads to their runaway growth.

Bostick and his colleagues are participating in a ten-year multi-center study of the effects of increased vitamin D and calcium and biomarker-guided treatment of colon cancer recurrence. The study involves almost 2,500 people nationwide who have regular colonoscopies.


'/>"/>

Contact: Ashante Dobbs
adobbs2@emory.edu
404-727-5692
Emory University
Source:Eurekalert

Related biology news :

1. Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake
2. Team finds an economical way to boost the vitamin A content of maize
3. New way to produce high-vitamin corn could improve nutrition in developing countries
4. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
5. Vitamin B-12 function may be diminished by excessive folate
6. Could vitamin D, a key milk nutrient, affect how you age?
7. Study shows vitamin C is essential for plant growth
8. Vitamin E trials fatally flawed
9. Low vitamin D linked to higher risk of hip fracture
10. Low vitamin D during pregnancy linked to pre-eclampsia
11. Community-intervention study links successful town makeover focused on boosting calcium and exercise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... ... June 28, 2017 , ... Today, FireRock Marketing, ... marketing efforts, announced that their new website has officially launched. Not only ... the site is the offering of no-cost SEO services. These online SEO reviews ...
(Date:6/28/2017)... ... June 28, 2017 , ... Ovation Fertility continues ... for presentation at the 33rd Annual Meeting of the European Society of ... the world’s top thought leaders in reproductive medicine – are expected to attend ...
(Date:6/27/2017)... ... ... The recent vote by the American Medication Association to align with the ... and hopefully sheds new light on the way health insurers, governments and the public ... partner of Texas Fertility Center . , “This designation is something we ...
(Date:6/27/2017)... ... June 27, 2017 , ... DuPont Pioneer (DuPont) and ... to the ERS patent portfolio covering CRISPR-Cas genome editing technology for all agricultural ... property (IP) of the CRISPR-Cas technology from co-inventor and co-owner Emmanuelle Charpentier, Ph.D. ...
Breaking Biology Technology: