Navigation Links
Vitamin D and calcium influence cell death in the colon, researchers find
Date:4/13/2008

Researchers at Emory University are learning how vitamins and minerals in the diet can stimulate or prevent the appearance of colon cancer.

Emory investigators will present their findings on biological markers that could influence colon cancer risk in three abstracts at the American Association for Cancer Research meeting in San Diego.

In a clinical study of 92 patients, supplementing diet with calcium and vitamin D appeared to increase the levels of a protein called Bax that controls programmed cell death in the colon. More Bax might be pushing pre-cancerous cells into programmed cell death, says Emory researcher Veronika Fedirko, who will present her team's results (abstract 464).

Previous studies have shown that calcium and vitamin D tend to reduce colon cancer risk.

"We were pleased that the effects of calcium and vitamin D were visible enough in this small study to be significant and reportable," Fedirko says. "We will have to fully evaluate each marker's strength as we accumulate more data."

The studies of colorectal biopsy samples are part of a larger effort to identify a portfolio of measurements that together can gauge someone's risk of getting colon cancer, says Roberd Bostick, MD, MPH, professor of epidemiology at Emory's Rollins School of Public Health.

"We want to have the equivalent of measuring cholesterol or high blood pressure, but for colon cancer instead of heart disease," Bostick says. "These measurements will describe the climate of risk in the colon rather than spotting individual tumors or cells that may become tumors."

More about Bostick's plans for developing non-invasive blood or urine tests for colon cancer risk is available in an Emory Health Sciences Magazine article: http://whsc.emory.edu/_pubs/hsc/winter08/pdf/hold_out_your_finger.pdf

Another abstract from Bostick and his colleagues (565) demonstrates in a 200-patient case-control study that high levels of calcium and vitamin D together are associated with increased levels of E-cadherin, which moderates colon cells' movement and proliferation.

A third abstract on the same case-control study (5504) shows that high levels of iron in the diet are linked to low levels of APC, a protein whose absence in colon cancer cells leads to their runaway growth.

Bostick and his colleagues are participating in a ten-year multi-center study of the effects of increased vitamin D and calcium and biomarker-guided treatment of colon cancer recurrence. The study involves almost 2,500 people nationwide who have regular colonoscopies.


'/>"/>

Contact: Ashante Dobbs
adobbs2@emory.edu
404-727-5692
Emory University
Source:Eurekalert

Related biology news :

1. Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake
2. Team finds an economical way to boost the vitamin A content of maize
3. New way to produce high-vitamin corn could improve nutrition in developing countries
4. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
5. Vitamin B-12 function may be diminished by excessive folate
6. Could vitamin D, a key milk nutrient, affect how you age?
7. Study shows vitamin C is essential for plant growth
8. Vitamin E trials fatally flawed
9. Low vitamin D linked to higher risk of hip fracture
10. Low vitamin D during pregnancy linked to pre-eclampsia
11. Community-intervention study links successful town makeover focused on boosting calcium and exercise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... , March 2, 2017 Who risk to ... Download the full report: https://www.reportbuyer.com/product/4313699/ ... FINGERPRINT SENSOR FIELD? Fingerprint sensors using capacitive technology ... fingerprint sensor vendor Idex forecasts an increase of 360% ... devices and of the fingerprint sensor market between 2014 ...
(Date:2/28/2017)... Feb. 28, 2017   Acuant , a leading ... announces significant enhancements to new and core technologies building ... products include mobile and desktop Acuant FRM TM ... - a real time manual review of identity documents ... provides the fastest and most accurate capture software to ...
(Date:2/27/2017)...   Strategic Cyber Ventures , the industry,s first ... $3.5 million investment in  Polarity , the first commercial ... DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran and ... series A round of funding. This new funding will ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... -- Research and Markets has announced the addition ... their offering. ... The Global Market for Bioproducts Should Reach $714.6 ... CAGR of 8.9%, This research report quantifies ... major product segments: bio-derived chemicals, biofuels, pharmaceuticals (biodrugs and herbal/botanicals), ...
(Date:3/23/2017)... -- GlobeImmune, Inc. today announced it has entered into a ... of its common stock to NantCell, Inc., a member ... sale of its common stock, NantCell has agreed to ... 200,000 shares, an estimated $2.0 million in value, of ... to enter into this strategic agreement with NantCell," said ...
(Date:3/23/2017)... SEATTLE , March 23, 2017 ... translational development of novel therapies in immuno-oncology, today ... to lead" small molecule compounds that activate interferon ... (RLR) pathways and demonstrate immune-mediated tumor regression in ... in the study who demonstrated complete tumor regression ...
(Date:3/23/2017)... Colo. , March 23, 2017  Agriculture technology ... Series A financing and note conversion to commercialize its ... Planet is focused on developing products that are simultaneously ... $30 million in the last 18 months. This latest ... North Bridge Venture Partners. The company,s ...
Breaking Biology Technology: