Navigation Links
Vitamin B and omega-3 supplementation and cancer: New data
Date:2/17/2012

However, women with a previous history of cardiovascular pathologies seem to have a higher cancer risk after five years of supplementation. The research is published in detail in the Archives of Internal Medicine.

Although some studies have suggested that supplementation with B vitamins has some benefits for protecting against cancer, the few randomised clinical trials conducted internationally in recent years remain equivocal.

The results of studies of the influence of supplementation with polyunsaturated fatty acids have been mixed.

That is why Valentina Andreeva and Pilar Galan and their staff wanted to study the effects of B vitamins and omega-3 polyunsaturated fatty acids (PUFAs) on cancer by monitoring, for five years from 2003 to 2009, more than 2500 people aged between 45 and 80 who had survived a heart attack, stroke or angina in the last 12 months.

The aim of the trial was to check the hypothesis that supplementation with en5-methyl-THF (and vitamins B6 and B12) and/or omega-3 was of value in preventing the recurrence of ischaemic pathologies in subjects who had suffered a heart attack or stroke.

The results, published this week in the Archives of Internal Medicine, are the outcome of a specific analysis performed as part of the intervention study SU.FOL.OM3, the results of which were published in 2010 in the British Medical Journal

SU.FOL.OM3 is a randomised double-blind placebo-controlled secondary prevention trial in which participants aged from 45 to 80 years with a previous history of cardiovascular pathologies were given daily supplements for five years of B vitamins (3 mg of vitamin B6, 560 μg of folates and 20 μg of vitamin B12) and/or omega-3 PUFAs (600 mg of eicosapentaenoic acid, EPA, and docosapentaenoic acid, DHA, in a ratio of 2:1), according to a factorial design.

It tested the effect of supplementation on cancer development over the five-year monitoring period in 145 men and 29 women.

All types of cancer were monitored

"Despite the low numbers, the results are significant," the authors believe, because the "methodology used a randomised double-blind trial is stringent".

The researchers conclude that "Neither B vitamin supplementation nor omega-3 PUFA supplementation has a significant effect on the occurrence of cancer in men. However, women receiving omega-3 fatty acids tended to present a higher risk of cancer compared with the placebo group (adjusted HR =3.02; CI of 95 % = [1.33; 6.89]). Although the underlying mechanisms are not clear, a potential mediating effect on the metabolism of oestrogens is suggested," they add.

To confirm or contradict these results, it is necessary to await new studies: randomised trials, cohort studies and mechanistic studies.


'/>"/>
Contact: Inserm - Presse
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related biology news :

1. Dont forget the vitamin A when working with its carrier protein
2. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
3. Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
4. Lack of vitamin D linked to Parkinsons disease
5. Vitamin K does not stem BMD decline in postmenopausal women with osteopenia
6. Optimal dose of vitamin E maximizes benefits, minimizes risk
7. Lung airway cells activate vitamin D and increase immune response
8. Could vitamin D save us from radiation?
9. Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease
10. Vitamin D found to fight placental infection
11. Calcium and vitamin D may not be the only protection against bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... NEW YORK , April 5, 2017 ... security, is announcing that the server component of the ... is known for providing the end-to-end security architecture that ... customers. HYPR has already secured over 15 ... system makers including manufacturers of connected home product suites ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... 2017 , ... Allotrope Foundation won the 2017 in Knowledge ... Allotrope Framework for commercial use. , The Bio-IT World Best Practices Awards ... critical role of information technology in modern biomedical research, but also to highlight ...
(Date:7/17/2017)... ... ... Whitehouse Laboratories is excited to announce that it has ... ISO 80369 standard test procedures. The ISO 80369 series of eight test standards ... this recent expansion, Whitehouse Labs becomes one of the only facilities in the ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... announced safety software company AB Cube has joined its eHealth App ... advance technology innovation across life sciences and healthcare. Under the partnership, AB ...
(Date:7/17/2017)... ... July 17, 2017 , ... Neurodevelopmental disorders (NDDs) are ... overlapping clinical features. The advancement of targeted next-generation sequencing (NGS) has been instrumental ... testing. , However, designing a custom panel for disease research requires hours ...
Breaking Biology Technology: