Navigation Links
Vitamin B-12 function may be diminished by excessive folate
Date:12/18/2007

BOSTON (December 18, 2007) In a study of adults aged 20 and over, researchers at Tufts University showed that homocysteine and methylmalonic acid are at much higher levels in individuals who have a combination of vitamin B12 deficiency and high blood folate levels than in individuals who are also vitamin B12 deficient but have normal folate levels.

Homocysteine and methylmalonic acid, compounds used by enzymes that contain vitamin B12, accumulate in the blood in patients who are vitamin B12 deficient. Finding that the combination of high blood folate levels and low vitamin B12 status is associated with even higher levels of these compounds is a strong indication that the high folate is interfering with the action of these B12-containing enzymes, thus resulting in the exacerbation or worsening of the vitamin B12 deficiency, says corresponding author Jacob Selhub, Ph.D., director of the Vitamin Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA).

In an earlier study, Selhub and co-authors Martha Savaria Morris, Ph.D., and Paul Jacques, D.Sc, also of the USDA HNRCA, have shown that the prevalence of anemia and cognitive impairment among U.S. elderly who are vitamin B12 deficient is much worse if this B12 deficiency is also accompanied by high blood folate rather than normal blood folate. This indicates that the worsening of the vitamin B12 deficiency, as indicated by higher homocysteine and methylmalonic acid due to high blood folate, is also manifested clinically through higher prevalence of anemia and cognitive impairment.

Results of the present study are published in the December 11 issue of the Proceedings of the National Academy of Sciences. Selhub and colleagues analyzed data from 10,413 adults who participated in two National Health and Nutrition Examination Surveys (NHANES). Slightly less than half of the participants (4,940) took part in phase 2 of the NHANE
'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. Low vitamin D during pregnancy linked to pre-eclampsia
2. Low vitamin D linked to higher risk of hip fracture
3. Vitamin E trials fatally flawed
4. Study shows vitamin C is essential for plant growth
5. Could vitamin D, a key milk nutrient, affect how you age?
6. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
7. Device helps patients survive, regain function til transplant
8. Specific brain protein required for nerve cell connections to form and function
9. Systems Biology poised to revolutionize the understanding of cell function and disease
10. Women more depressed and men more impulsive with reduced serotonin functioning
11. Researchers expand efforts to explore functional landscape of the human genome

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/9/2009)...d Queller and Joan Strassmann argue in a new paper...mponents, from the genetic level on up, give a liv...is an animal, a plant, a bacteria or a colony. ,... organism, such as individuality or even membershi...ieve organismality. What is necessary, they argue,...
(Date:11/9/2009)...ired a 3.2m, three-year research project that prom...ty, energy and the environment. The University of ...Q have just signed a collaborative contract to dev...ical sciences research. , Over the next three y...xeter and QinetiQ will work together to develop ne...
(Date:11/9/2009)...id, mysterious death of phytoplankton in the North...ientists at Rutgers University and the Woods Hole ...cal may hold unexpected promise in cancer research...id, or fatty compound, in a virus that has been at...ankton that plays a major role in the global carbo...
Breaking Biology News(10 mins):What is the meaning of 'one'? 2What is the meaning of 'one'? 3£3.2m ($5.4 million) research project to capture brilliance of butterfly wings 2Newly discovered fat molecule: An undersea killer with an upside 2Newly discovered fat molecule: An undersea killer with an upside 3Newly discovered fat molecule: An undersea killer with an upside 4How to make negative services less unpleasant for consumers 53970 1Fumbled handoffs can lead to medical errors 53967 1Fumbled handoffs can lead to medical errors 53967 2Nuvo Announces 2009 second quarter financial results 53966 1Nuvo Announces 2009 second quarter financial results 53966 2Nuvo Announces 2009 second quarter financial results 53966 3Nuvo Announces 2009 second quarter financial results 53966 4Nuvo Announces 2009 second quarter financial results 53966 5Nuvo Announces 2009 second quarter financial results 53966 6Nuvo Announces 2009 second quarter financial results 53966 7Nuvo Announces 2009 second quarter financial results 53966 8Nuvo Announces 2009 second quarter financial results 53966 9Nuvo Announces 2009 second quarter financial results 53966 10Nuvo Announces 2009 second quarter financial results 53966 11Nuvo Announces 2009 second quarter financial results 53966 12
...g been encouraging Americans to add more fruits an...esearchers have discovered one way in which flavon...vity that leads to the development of chronic dise...ers. , "We,ve known for a long time that it,s the ... We just haven,t known exactly how. Now, at least ...
... monkeys were asked to manipulate computer cursors...ain,s "executive" center plans behaviors not by sp... rather the events that will result from those act...esearchers, because it yields new basic insight in...is higher brain region, called the lateral prefron...
...niversity of Georgia researchers shows that the co...isease outbreaks can actually make matters worse i... edition of the journal Proceedings of the Royal S...rcher Marc Choisy and Pejman Rohani, associate pro...iences Institute researcher, create a detailed mat...
Other Biology News:UC Davis researchers reveal apples' protective ways 2Himalayan forests disappearing 2UGA researchers find that hunting can increase the severity of wildlife disease epidemics 2
(Date:11/9/2009)..., VIENNA, Va., Nov. 9 ...oday that Dr. Kenneth S. Rosenthal, Professor of I...iversities College of Medicine and Pharmacy, repor...ists at the Cleveland Clinic and CEL-SCI on CEL-SC...ted at the 7th GTCbio Vaccine: "All Things Conside...
(Date:11/8/2009)...,, MOUNTAIN VIEW, Calif. Nov. 5, 2009 Comple...ncing company, today announced publication of a re...ietary DNA sequencing platform, including analysis...s. The consumables cost for these three genomes se...arrays ranged from $8,005 for 87x coverage to $1,7...
(Date:11/6/2009)..., QUINCY, Mass., Nov. 6 Myriant ...otech developer and manufacturer of renewable bio...eferred technology provider Uhde GmbH, one of the ...Uhde"), announced an alliance for the engineering,... biobased Succinic Acid plants based on renewable ...
(Date:11/6/2009)..., HAYWARD, Calif., Nov. 6 Intarc...today on its ITCA 650 (DUROS® continuous deli...pe 2 diabetes at the Ninth Annual Diabetes Technol...tp://www.newscom.com/cgi-bin/prnh/20050301/SFTU126... Exenatide Via ITCA 650 Lowers Plasma Glucose, HbA...
Breaking Biology Technology:CEL-SCI Collaborators Present Data Suggesting That LEAPS Technology Has Ability to Modify Immune Response 2CEL-SCI Collaborators Present Data Suggesting That LEAPS Technology Has Ability to Modify Immune Response 3Complete Genomics publishes in Science on low-cost sequencing of 3 human genomes 2Myriant Technologies LLC, Uhde Corporation of America and Uhde GmbH Announce Alliance for Engineering, Procurement & Construction of World Scale Renewable Succinic Acid Plants 2Myriant Technologies LLC, Uhde Corporation of America and Uhde GmbH Announce Alliance for Engineering, Procurement & Construction of World Scale Renewable Succinic Acid Plants 3Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 2Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 3Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 4Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 5
... participation of the Consejo Superior de Investig...iment of Thomas Young in a molecule of hydrogen, t...the English scientist tested a pattern of interfer...hrough a double slit and thus being refracted. Thi... motion properties. The authors of this current re...
...climate,and appealing lifestyle, Florida is fast b...tes. Statewide, Florida,s high-tech industries ad...76,400 jobs, according to Florida Cybercities,2007...ciation (AeA) using,the most current state data av...s, Florida was the second,fastest growing "cyberst...
...oration (Nasdaq: MATK ) announced today that the ...(EPO) has ruled in favor of Martek and upheld,one ...A) patents. The,modified claims of the patent are ...oader than the claims that were previously upheld ...e patent, which expires in,November 2010, relates ...
Other Biology Technology:Young's experiment in a hydrogen molecule 2Florida's Technology Sector Attracting Skilled Workers Needing Homes 2European Patent Office Upholds Martek European DHA Food Patent; Scope of Original Claims Narrowed 2European Patent Office Upholds Martek European DHA Food Patent; Scope of Original Claims Narrowed 3
Tumor Suppressor Sampler Kit from BD Biosciences Pharmingen
Eosinophil Chip-IHC from 3H Biomedical AB
B Cell Chip-IHC from 3H Biomedical AB
Basophil Chip-IHC from 3H Biomedical AB
Biology Products: