Navigation Links
Vitamin A used in acne medicines may help autoimmune and transplant patients
Date:1/30/2014

The same form of Vitamin A used by teenagers to combat acne might offer benefits that are more than skin deep. That's because an international team of researchers have found that it may also help keep the immune system under control for people with autoimmune disorders or those who have received transplants. This finding was published in the February 2014 issue of the Journal of Leukocyte Biology.

"The results will help us to use the different protocol of Treg induction for clinical therapy in autoimmune diseases and organ transplantation protection,'" said Song Guo Zheng, M.D., Ph.D., a Professor of Medicine and leading author involved in the work from the Department of Medicine, Autoimmunity Research Center at Penn State University Hershey College of Medicine, in Hershey, Pennsylvania.

To make this discovery, scientists used cells isolated from mice and humans to conduct a head-to-head comparison of the role of all-trans retinoid acid (ATRA) on CD4+ and CD8+ Treg cell development. While ATRA significantly promoted CD4+Foxp3+Treg development and function in mice and humans, it did not boost the differentiation and function of CD8+Foxp3+Treg. On the contrary, ATRA interfered with the differentiation and function of human CD8+Foxp3+Treg. This suggests that ATRA-treated CD4+Treg is superior to ATRA-treated CD8+Treg for the treatment of autoimmune disease and organ transplantation. This lays the groundwork for the potential development of specific Treg subsets to combat specific autoimmune diseases and complications.

"The great thing about this discovery is that we already have a strong foundation of clinical use of this form of Vitamin A and know that it is well-tolerated by people," said E. John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These findings are a great example of the ability to exploit currently used drugs and our growing molecular and cellular understanding of the immune system. Such approaches represent exactly the kind of merging of basic science and clinical medicine that defines translational research."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Low vitamin D levels during pregnancy may increase risk of severe preeclampsia
2. FASEB announces 2014 Science Research Conference: Folic Acid, Vitamin B12 and One Carbon Metabolism
3. Boosting vitamin D could slow progression, reduce severity of multiple sclerosis
4. Vitamin D supplements reduce pain in fibromyalgia sufferers
5. Higher vitamin D levels associated with better cognition and mood in PD patients
6. Most clinical studies on vitamins flawed by poor methodology
7. HCG Injections and B12 shots now in stock at US Vitamin Injections Site
8. New UK study suggests low vitamin D causes damage to brain
9. Vitamin C could ease muscle fatigue in chronic obstructive pulmonary disease patients
10. Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
11. Mouse studies reveal promising vitamin D-based treatment for MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... For the ... has produced a Spotlight series on “Cell Therapy Regulation” for its ... leading experts on the unique regulatory challenges of stem cell medical research. , ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext , Connecticut’s ... has formed a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of ... other high-ranking representatives from 35 higher education institutions across the state over the ...
(Date:6/20/2017)... , ... June 20, 2017 , ... Do More with ... transition from being a trusted supplier in the weighing industry, to extending its expertise ... ELISA essays, enzyme reactions, immunoassays, hybridizations and more, allowing for its customers ...
(Date:6/19/2017)... ... ... A colony of healthy honey bees is like a superorganism--individual bees provide the ... nutrients necessary for growth and survival. Better nutrition gives the colony a strong immune ... decline in honey bee health. Sick and weakened bees diminish the colony's resiliency, leading ...
Breaking Biology Technology: