Navigation Links
Vitamin A used in acne medicines may help autoimmune and transplant patients
Date:1/30/2014

The same form of Vitamin A used by teenagers to combat acne might offer benefits that are more than skin deep. That's because an international team of researchers have found that it may also help keep the immune system under control for people with autoimmune disorders or those who have received transplants. This finding was published in the February 2014 issue of the Journal of Leukocyte Biology.

"The results will help us to use the different protocol of Treg induction for clinical therapy in autoimmune diseases and organ transplantation protection,'" said Song Guo Zheng, M.D., Ph.D., a Professor of Medicine and leading author involved in the work from the Department of Medicine, Autoimmunity Research Center at Penn State University Hershey College of Medicine, in Hershey, Pennsylvania.

To make this discovery, scientists used cells isolated from mice and humans to conduct a head-to-head comparison of the role of all-trans retinoid acid (ATRA) on CD4+ and CD8+ Treg cell development. While ATRA significantly promoted CD4+Foxp3+Treg development and function in mice and humans, it did not boost the differentiation and function of CD8+Foxp3+Treg. On the contrary, ATRA interfered with the differentiation and function of human CD8+Foxp3+Treg. This suggests that ATRA-treated CD4+Treg is superior to ATRA-treated CD8+Treg for the treatment of autoimmune disease and organ transplantation. This lays the groundwork for the potential development of specific Treg subsets to combat specific autoimmune diseases and complications.

"The great thing about this discovery is that we already have a strong foundation of clinical use of this form of Vitamin A and know that it is well-tolerated by people," said E. John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These findings are a great example of the ability to exploit currently used drugs and our growing mo
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Low vitamin D levels during pregnancy may increase risk of severe preeclampsia
2. FASEB announces 2014 Science Research Conference: Folic Acid, Vitamin B12 and One Carbon Metabolism
3. Boosting vitamin D could slow progression, reduce severity of multiple sclerosis
4. Vitamin D supplements reduce pain in fibromyalgia sufferers
5. Higher vitamin D levels associated with better cognition and mood in PD patients
6. Most clinical studies on vitamins flawed by poor methodology
7. HCG Injections and B12 shots now in stock at US Vitamin Injections Site
8. New UK study suggests low vitamin D causes damage to brain
9. Vitamin C could ease muscle fatigue in chronic obstructive pulmonary disease patients
10. Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
11. Mouse studies reveal promising vitamin D-based treatment for MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
(Date:4/8/2015)... CHARLOTTE, N.C. , April 8, 2015 /PRNewswire/ ... technology solutions and services, and Morpho, a leading ... in partnership to produce the market,s most advanced ... Infinisource,s iSolved NXG time clock is setting ... attendance and labor data for the small and ...
(Date:4/2/2015)... April 2, 2015 At its 2015 ACMG ... City , the American College of Medical Genetics ... directors to its Board.  Members of the ACMG Board ... for forming and advancing its policies and programs. ACMG ... "It,s an eventful time in medical genetics ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... from the Wildlife Conservation Society and other groups have ... exposure to stress factors, including high temperatures, ultra-violet radiation, ... as temperature variability and tidal dynamics. The study, ... the world,s most important coral reefs by identifying reef ...
... Although phosphorus is an essential nutrient for all ... can cause water quality problems in rivers, lakes, ... aquatic ecosystems are often associated with human activities ... urban development. However, relationships between specific human sources ...
... , This release is available in Spanish ... scientist is trying to learn what is causing the decline ... species that can serve as the next generation of greenhouse ... of native plants and are used to pollinate greenhouse crops ...
Cached Biology News:Worldwide map identifies important coral reefs exposed to stress 2Worldwide map identifies important coral reefs exposed to stress 3Urban impacts on phosphorus in streams 2The flight of the bumble bee: Why are they disappearing? 2
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... that develops and commercializes proprietary technologies and products for ... results for the second fiscal quarter ended March 31, ... continued to advance business with our existing customers and ... President and CEO of SQI. "The delivery of a ...
(Date:5/21/2015)... May 21, 2015  Prima Biomed Ltd. (NASDAQ: ... striving to become a leader in the development of ... that the final CVac data from the Phase II ... trend for a clinically meaningful improvement in Overall Survival ... patients. In the group of second remission ...
(Date:5/21/2015)... 2015 W. R. Grace & ... in Worms, Germany has received good manufacturing practice ... the International Pharmaceutical Excipient Council (IPEC) Foundation. ... its SYLOID® FP brand of pharmaceutical grade excipient ... the Curtis Bay, Maryland (USA) and Sorocaba, Brazil ...
(Date:5/21/2015)... May 20, 2015 Research and Markets ... of the "2015 Global Survey on Flow ... The primary goal of this research ... instruments and reagents. Key information the survey seeks ... of flow cytometers, predominantly used applications for flow ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Correction Continues after Big Move - BrokerBank Securities, Inc. 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Global Survey on Flow Cytometry Adoption Trends 2015 2
... in the Diagnosis of Uncertain ... ... Pathwork Diagnostics, Inc.,a genomics-based diagnostics company focused on oncology, today announced,the ... Diagnostics Laboratory. The new test aids in the diagnosis of,tumors of ...
... Renovis, Inc.,(Nasdaq: RNVS ), today announced that Glass ... ISS/Risk Metrics in recommending that Renovis,stockholders vote "FOR" the ... the Special Stockholders Meeting scheduled for May,1, 2008. In ... will be,converted into the right to receive the equivalent ...
... ABBOTT PARK, Ill. and ST. PAUL, ... MD will promote and distribute Abbott,s ... ). Smiths Medical MD is the ... http://www.smiths-medical.com/markets/diabetes/ ) and the Deltec Cozmo,insulin ...
Cached Biology Technology:Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory 2Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory 3Glass Lewis & Co. Recommends Renovis Shareholders Vote For Merger With Evotec 2Glass Lewis & Co. Recommends Renovis Shareholders Vote For Merger With Evotec 3Smiths Medical to Promote and Distribute Abbott's FreeStyle Navigator Continuous Glucose Monitoring System 2Smiths Medical to Promote and Distribute Abbott's FreeStyle Navigator Continuous Glucose Monitoring System 3Smiths Medical to Promote and Distribute Abbott's FreeStyle Navigator Continuous Glucose Monitoring System 4
Glucagon-like peptide-1 (GLP-1 (1-36) amide)...
Complement factor B (human)...
... kinase) signal transduction cascade is one ... in mammals. JNK pathway activation occurs ... associated with the nuclear accumulation of ... the immune response, cellular proliferation, oncogenic ...
... near- and far-infrared range FT-IR spectrometers give ... their class. Yet all this comes at ... throughput: Having a larger and faster ... other conventional FT-IRs provides 300%,larger solid angle ...
Biology Products: