Navigation Links
Vitamin A pushes breast cancer to form blood vessel cells
Date:7/15/2008

Washington, DC Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumor growth.

They say their findings, published in the July 16 online issue of PLoS ONE, is a proof of principle of the new and controversial "vasculogenic mimicry" theory, proposing that, as needed, tumors build their own blood pipelines. This is very different from the well-accepted role of tumor angiogenesis, when tumors send signals to blood vessels to grow toward the cancer.

The study's senior author, Stephen W. Byers, Ph.D., a professor of oncology and cell biology at Georgetown's Lombardi Comprehensive Cancer Center, also says that this study helps explain why retinoids-- natural or synthetic vitamin A agents--have had mixed results in treating cancer. "Finding that vitamin A may cause some breast cancer cells to form blood vessels brings up the rather disturbing notion that treatment with these drugs may actually stimulate tumor growth," says Byers.

For example, use of beta-carotene, the most important dietary precursor of vitamin A and the chemical that makes carrots orange, has been found to increase lung cancer progression in a large clinical trial. Additionally, fenretinide, a synthetic retinoid, appears to reduce the risk of second breast cancers in premenopausal women, but increase the risk in postmenopausal women, Byers says.

"None of this means that people should avoid foods rich in vitamin A, or should refuse to take their vitamins," he says. "What led us to this study is that previous research on retinoids implied that they may be effective in a preventative setting, but may actually have a negative effect after tumor initiation and during progression."

The research
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
414-312-7085
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify cancer preventive properties in common vitamin supplement
2. Newborn vitamin A reduces infant mortality
3. New technology may prevent vitamin B12 deficient seniors and vegetarians from needing injections
4. Vitamin D: New way to treat heart failure?
5. Moores UCSD Cancer Center study links vitamin D, type 1 diabetes
6. Study identifies trends of vitamin B6 status in US population sample
7. Vitamin D in brain function
8. Vitamin D and calcium influence cell death in the colon, researchers find
9. Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake
10. Team finds an economical way to boost the vitamin A content of maize
11. New way to produce high-vitamin corn could improve nutrition in developing countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 30, 2014) People who suffer from asthma may ... control their asthma besides properly taking medications and avoiding ... in the Annals of Allergy, Asthma and Immunology ... Allergy, Asthma and Immunology (ACAAI), asthma sufferers can learn ... The woman described in the Annals article improved her ...
(Date:9/29/2014)... ramosum , coupled with a high-fat diet, may cause animals ... mBio , the online open-access journal of the American ... German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that ... gained weight when fed a high-fat diet. Mice that did ... when consuming a high-fat diet, and mice that had ...
(Date:9/29/2014)... 29, 2014 -- Plants have a symbiotic relationship ... pants extract nutrients and defend against invaders ... fruits and vegetables. Now, scientist have discovered that ... seeds; thus ensuring that sprouting plants are colonized ... of Notre Dame, presented their findings today at ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Gut bacteria promote obesity in mice 2Plants prepackage beneficial microbes in their seeds 2
... volume transmitted every second with every quick eye movement ... Ruhr-Universitt Bochum (RUB) and the University of Osnabrck describe ... visual cortex, the entry point for the visual information ... ". Deploying novel optical imaging methods, they demonstrated that ...
... University researchers have shown natural radioactivity within DNA can ... mutation. The research, recently published in Biochimica ... looked at natural radioactivity within human DNA on the ... bodies as well as in every living organism across ...
... explanation for how the most common strain of methicillin-resistant ... prominence. Research published in mBio , the online ... that the strain recently acquired a number of genes ... and thrive on the skin where other strains of ...
Cached Biology News:Neurons subtract images and use the differences 2Neurons subtract images and use the differences 3Radioactivity muddles the alphabet of DNA 2MRSA strain gained dominance with help from skin bacteria 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 OriginOil Inc. ... high-speed, chemical-free process to clean up large quantities of ... CEO Riggs Eckelberry reported on the launch of the ... a site provided by partner STW Resources . ... 1000 barrels per day (bpd) and achieved a 99.8% ...
(Date:9/30/2014)... BioHealth Innovation, Inc. (BHI), a ... and increasing access to early-stage funding in ... Tania Fernandez , Ph.D., has joined the BHI ... a member of the management team for a new ... million in seed and early-stage equity investments to therapeutics, ...
(Date:9/30/2014)... September 30, 2014 iLab Solutions announced ... Benchmarking study which focuses on core facility operations, ... core managers face today. , In its 4th year ... of note is the year-over-year decrease in the percentage ... appear to be feeling the constraints of this trend. ...
(Date:9/30/2014)... The custom stainless steel fabrication company HOLLOWAY AMERICA ... Boston Area Chapter of ISPE (International Society for Pharmaceutical ... Wed., Oct. 1 at Gillette Stadium Clubhouse in Foxborough, ... ISPE Boston’s long history, with more than 375 exhibitors ... , HOLLOWAY AMERICA President David Simpson is looking forward ...
Breaking Biology Technology:OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3
... Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today ... of its manufacturing process for,REOLYSIN(R) to commercial ... production and downstream processing,development was undertaken by ... located in Montreal, Canada., "Our existing ...
... Industry Expertise to Pathwork Following FDA ... Clearance and $20M Fundraising Round, SUNNYVALE, ... on oncology, announced today the,appointment of two key positions within ... Mark McDonough as Vice,President of US Sales. These professionals bring ...
... CJPS Enterprises, LLC, (http://www.CJPS-Enterprises.com ), the operator ... ) is announcing a new service available,to ... business, or looking to,invest in Michigan companies ... existing resources available on the Michigan Life ...
Cached Biology Technology:Oncolytics Biotech Inc. Completes Initial Scale Up of Manufacturing Process for REOLYSIN(R) to Commercial Scale 2Pathwork Diagnostics Announces Key Additions to Management Team 2The Michigan Life Sciences Pipeline Announces 'The Funding Place(TM)' and Other Resources to Connect Investors and Startups 2
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
... DNA Polymerase I from ... DNA polymerase. The enzyme also ... activities.1 The 5'?3' exonuclease activity ... nicks and gaps in the ...
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
... thymus Description: Topoisomerase I relaxes both ... breakage and rejoining of phosphodiester bonds (1,2) . ... to be differentiated by a single nucleotide pair ... active in the absence of Mn 2+ ...
Biology Products: