Navigation Links
Visualizing virus replication in three dimensions
Date:5/7/2009

Dengue fever is the most common infectious disease transmitted by mosquitoes some 100 million people around the world are infected. Researchers at the Hygiene Institute at Heidelberg University Hospital were the first to present a three-dimensional model of the location in the human cell where the virus is reproduced. Their research provides an insight into the exact process of viral replication and serves as a model for other viruses whose replication is still unclear, such as the hepatitis C virus. In addition, it offers new approaches for developing measures to prevent or treat dengue fever. Up to now, neither a vaccine nor a specific antiviral therapy exists.

Professor Dr. Ralf Bartenschlager, director of the Department of Molecular Virology at the Heidelberg Hygiene Institute and his team, working in cooperation with colleagues from the European Molecular Biology Laboratory (EMBL) have published their study in the latest issue of the prestigious journal Cell Host & Microbes.

Viruses do not have a metabolism and cannot produce proteins from their genetic material (RNA or DNA) on their own. They can replicate only inside a host cell but where and how exactly does this take place? The answer to this question is crucial for developing therapy.

Viruses transform human cell membranes for their purposes

Dengue viruses reproduce in what is known as the endoplasmic reticulum, a membrane network interconnected with the nuclear envelope; this is where proteins are synthesized. The dengue virus uses this membrane network and transforms it for its own use.

"We now know that viral RNA is replicated in vesicles in the endoplasmic reticulum and is secreted through tiny pores. We were also able to show that replication of the virus genome and its encapsulation in new virus particles are directly linked," said Professor Bartenschlager. The new virus genomes are secreted through pores into the intracellular space where they are incorporated into pre-stages of viruses and then penetrate the endoplasmic reticulum a second time. There they are enveloped in a membrane that disguises them for the cell so that they can be secreted like normal cellular material. The reproduction cycle can begin again.


'/>"/>

Contact: Prof. Dr. Ralf Bartenschlager
Ralf_Bartenschlager@med.uni-heidelberg.de
0041-622-156-4569
University Hospital Heidelberg
Source:Eurekalert  

Related biology news :

1. Broad Institute researchers introduce next generation tool for visualizing genomic data
2. Novel antibody prevents infection by hepatitis C virus
3. K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
4. FluChip technology licensed to combat deadly flu virus
5. Findings uncover new details about mysterious virus
6. Minimizing the spread of deadly Hendra virus
7. MDC researchers prevent virus induced myocarditis
8. West Nile virus studies show how star-shaped brain cells cope with infection
9. Catching the common cold virus genome
10. Epstein-Barr virus may be associated with progression of MS
11. Frogs immune system is key in fight against killer virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Visualizing virus replication in three dimensions
(Date:3/2/2017)... March 2, 2017 Australian stem cell and ... CYP), has signed an agreement with the Monash Lung ... Biomedicine Discovery Institute and Department of Pharmacology at Monash ... further preclinical study to support the use of Cymerus™ ... Asthma is a chronic, long term ...
(Date:2/28/2017)... ANGELES , Feb. 28, 2017   Acuant ... verification software globally, announces significant enhancements to new and ... May 2016. New products include mobile and desktop Acuant ... DocX TM - a real time manual review ... core idScan® technology provides the fastest and most accurate ...
(Date:2/28/2017)... BARCELONA , Spanien, 27. Februar 2017 /PRNewswire/ ... durch Iris-Scan, wird seine erstklassige biometrische Lösung ... Snapdragon™ 835 mit X16 LTE auf dem ... 2. März) am Qualcomm-Stand in Halle 3, ... 835-Prozessor beinhaltet die Sicherheitsplattform Qualcomm Haven™ – ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... ... 2017 , ... Ellen Matloff, president and CEO of My ... a 2017 Women of Innovation® finalist. Matloff will be among several women to ... dinner recognizes women accomplished in science, technology, engineering and math (STEM), along with ...
(Date:3/23/2017)... In today,s pre-market research, Stock-Callers.com ... Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate Pharmaceuticals ... and Regulus Therapeutics Inc. (NASDAQ: RGLS ). ... its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn more ... ...
(Date:3/22/2017)... MONICA, Calif. , March 22, 2017 /PRNewswire/ ... are proud to announce their extended partnership and ... will be headlined by the 21 st ... BIOMEDevice Boston, taking place May 3-4, 2017. ... Advanced Medical Technology Association (ADVAMED) President and CEO, ...
(Date:3/22/2017)... MarketNewsUpdates.com News Commentary  ... The traditional ways to ... as of late due to the rise of the opioid ... dramatic impact on patient,s quality of life as Biotech and ... new forms of opioid formulations that prevent abuse. Biotech and ...
Breaking Biology Technology: