Navigation Links
Viruses evolve to play by host rules, according to University of Pennsylvania researchers
Date:3/3/2008

PHILADELPHIA -- Biologists at the University of Pennsylvania and Harvard University have examined the complete genomes of viruses that infect the bacteria E. coli, P. aeruginosa and L. lactis and have found that many of these viral genomes exhibit codon bias, the tendency to preferentially encode a protein with a particular spelling.

Researchers analyzed patterns of codon usage across 74 bacteriophages using the concept of a "genome landscape," a method of visualizing long-range patterns in a genome sequence.

Their findings extend the translational theory of codon bias to the viral kingdom, demonstrating that the viral genome is selected to obey the preferences of its host.

The host bacterium is exerting a strong evolutionary pressure on the virus, Joshua Plotkin, lead author and assistant professor in the Department of Biology at Penn, said. This happens because a virus must hijack the machinery of its host in order to reproduce. We are seeing that viruses are forced to adopt the particular codon choices preferred by the bacterium they infect.

The study found that each bacterium has a preferred way of spelling its genes. And it appears that viruses that infect a bacterium spell their own genes in the same way the bacterium does, obeying the rules of its host and demonstrating co-evolutionary behavior.

Like a bee and a flower, an example of co-evolution between two large organisms, the same fundamental biological processes operate between two small organisms, as reflected in their genome sequences, Plotkin said.

Moreover, the team found that the degree of codon bias varies across the viral genome. By comparing the observed genomes to randomly drawn genomes, the team demonstrated that the regions of high codon bias in these viral genomes often coincide with regions encoding structural proteins. Thus, the proteins that a virus needs to produce at high leve
'/>"/>

Contact: Jordan Reese
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Features of replication suggest viruses have common themes, vulnerabilities
2. Gamma globulin effective in treating eye infections caused by adenoviruses
3. Discovery may help defang viruses
4. Prions and retroviruses -- an unholy alliance?
5. Study proposes new theory of how viruses may contribute to cancer
6. Iowa State researchers develop technology for early detection of viruses
7. Yellowstone viruses jump between hot pools
8. Great apes endangered by human viruses
9. The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
10. MGH researchers describe new way to identify, evolve novel enzymes
11. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... years, Virginia Tech,s Wu Feng has built upon a ... "Computing in the Cloud" program, and synergistically complemented it ... from the Air Force on "big computing" for mini-drones ... National Institutes of Health on "big data" for the ... computing" aspects from each grant, he was able to ...
(Date:8/20/2014)... of honeybees grows to about 4,000 members, it triggers ... building of a special type of comb used for ... from the Department of Neurobiology and Behaviour at Cornell ... reproductive cycle of honeybee colonies. The results are published ... Nature . , Reproduction isn,t always a honeybee ...
(Date:8/20/2014)...  The second annual Biometrics UnPlugged Executive Summit, ... Florida on September 15, 2014, will ... and Strategy at Samsung, and Philippe de Raet, Vice ... this year,s event is Mobility at the Crossroads ... UnPlugged: Mobility at the Crossroads of Commerce & ...
Breaking Biology News(10 mins):The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4Worker bees 'know' when to invest in their reproductive future 2Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2
... created a synthetic protein that, when activated by ultraviolet light, ... arthritis and other serious medical disorders can be detected. ... imaging technology and may someday serve as a way to ... disease have been found. In a study published in the ...
... be changed by a restaurant,s choice of music and lighting, ... a new study., "When we did a makeover of a ... diners to eat 175 fewer calories and enjoy it more," ... and director of Cornell University,s Food and Brand Lab. ...
... Conn., Aug. 29, 2012 /PRNewswire-iReach/ -- The biobanking market presents ... drug and treatment development for specific diseases. The global ... is projected to increase by 30% between 2010 and 2015, ... sector biobanks will experience the greatest increase with growth of ...
Cached Biology News:Collagen-seeking synthetic protein could lead doctors to tumor locations 2Collagen-seeking synthetic protein could lead doctors to tumor locations 3Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015 2Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015 3
(Date:8/21/2014)... 21, 2014  Four-dimensional (4-D) printing develops materials ... external stimuli such as changes in temperature. This ... effect in multiple industries.  In the near future, ... printing objects ranging from human organs to parts ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... 21, 2014 On Wednesday of last week ... use Redox Signaling molecules, became available for purchase in Australia ... "The way that RENU 28 works is, if you think ... of the rate of cellular renewal within your body. If ... of that rate of cellular renewal. What RENU 28 does ...
(Date:8/20/2014)... , Aug. 20, 2014 Neurotrope, ... host a conference call to provide an update ... p.m. Eastern daylight timeDial-in numbers:(888) 505-4369 (U.S. and ... Live web cast: www.neurotropebioscience.com , under "Investor Relations"The ... after completion through September 2, 2014 at (888) ...
(Date:8/20/2014)... 20, 2014 Not long ago, it ... should be performed late in the development cycle – ... current regulatory trends suggest that, like many things GxP, ... In recent years, multiple drug sponsors have been required ... specific questions during phase I/II. It’s not only clinical ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Neurotrope To Host Conference Call 2Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... BioSciences Inc.,(AMEX: YMI , TSX: YM, AIM: ... differentiated products for patients worldwide,today announced that clinical ... nimotuzumab, a humanized monoclonal antibody that targets,the epidermal ... American,Society of Clinical Oncology (ASCO) Annual Meeting being ...
... MONTVALE, N.J., June 3 Contemporary ... dedicated to enhancing the surgeon,s,practice, has announced ... tool:,SURGERYFINDIT.COM ( http://www.SURGERYFINDIT.COM )., As part ... surgeons with a wealth of peer-reviewed, practical ...
... 3 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI ... device company, today announced the completion of U.S. ... track plug., "Our proprietary Bio-Seal product represents ... diagnose lung cancer," said Dr.,William Hunter, President and ...
Cached Biology Technology:NIMOTUZUMAB CLINICAL DATA PRESENTED AT ASCO ANNUAL MEETING 2NIMOTUZUMAB CLINICAL DATA PRESENTED AT ASCO ANNUAL MEETING 3NIMOTUZUMAB CLINICAL DATA PRESENTED AT ASCO ANNUAL MEETING 4SURGERYFINDIT.COM and Convera(R) Launch Vertical Search Site for Surgeons 2Angiotech announces completion of Bio-Seal(TM) clinical trial enrolment 2Angiotech announces completion of Bio-Seal(TM) clinical trial enrolment 3Angiotech announces completion of Bio-Seal(TM) clinical trial enrolment 4
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... to Asparagine synthetase ( Abpromise ... Antigen: ... in the C-terminus of Human ... Entrez GeneID: 440 ...
Biology Products: