Navigation Links
Viruses, start your engines!
Date:12/29/2008

inal genetic tools to understand virus assembly were developed," adds biologist Venigalla Rao of Catholic University, also a lead researcher on the study. "T4 has been an important model system to tease out the details of basic mechanisms by which viruses assemble into infectious particles."

For the recent study, analyses involved two sophisticated instruments capable of studying structures at the nanometer (billionth of a meter) scale. One of the techniques, x-ray crystallography, showed the ordered arrays of atoms in the various structures, while another, called cryo-electron microscopy, let the researchers study the broader shape of the structures without the need for coating or drying out the specimens.

Having already determined the structures of a number of other viral components and how they self-assemble, in this study the researchers focused their attention on the small motor that some viruses use to package DNA into their "heads", protein shells also called capsids.

Not all viruses have a motor such as the one found in the T4 virus, but some viruses that cause human diseases posses molecular motors with similar functions, and likely have similar structures. T4 uses its motor to pack about 171,000 basepairs of genetic information to near-crystalline density within its 120 nanometer by 86 nanometer capsid.

The researchers found that the motor is located at the intersection of the capsid and the virus "tail" and is made of a circular array of proteins called gene product 17 (gp17). Five, two-part, gp17 proteins combine to form a pair of conjoined rings, arrayed so that their upper segments form an upper ring and their lower segments form a lower ring.

As a T4 virus assembles itself, the lower ring of the motor structure attaches to a strand of DNA, while the upper ring attaches to a capsid. The upper and lower rings have opposite charges, which allow the motor to contract and release, alternately tugging at the DNA
'/>"/>

Contact: Joshua A. Chamot
jchamot@nsf.gov
703-292-7730
National Science Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Viruses, oxygen and our green oceans
2. Girls who begin dieting twice as likely to start smoking
3. Shape encoding may start in the retina
4. Freshman class sparks start-up company
5. Starting university may be hazardous to your health: study
6. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
7. Starters orders for unique Ph.D.s in sport
8. NJIT start-up company NeuroTrax named best in show
9. Alzheimers starts earlier for heavy drinkers, smokers
10. No time to lose to start thinking sustainability
11. Trustee makes donation to start new solar energy research center at Rensselaer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
(Date:11/21/2014)... YORK , Nov. 19, 2014  Earlier this ... at New York College, and one of the most ... biosensor signals that are transmitted from Smartphones to third ... were Smartphones and has one of the earliest known ... discussing its usage in the military, child care, elder ...
(Date:11/18/2014)... Nov. 18, 2014  The Secure Identity & ... today jointly announce the formation of The Airport ... its Identity and Biometric Entry and Exit ... received official support from BORDERPOL, the international non-profit ... and provide expertise regarding border security, traveler and ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... conflict in Sri Lanka kills more than 70 humans and ... tools in combating these conflicts is moving the elephants into ... done in hopes of avoiding problems that include elephants raiding ... But according to a new study to be published Dec. ...
... release is available in German . ... new Research Units and one new Clinical Research Unit. This ... meeting in Bonn. The purpose of the collaborations is to ... in their subject areas and to establish innovative work directions. ...
... Long ago, when life on Earth was in its infancy, ... vast prehistoric ocean by beating whip like tails called flagella. ... 800 million years later, these organisms have evolved into parasites ... ocean may be the key to stopping them. The ...
Cached Biology News:Relocating elephants fails to decrease human-wildlife conflict 23 new research units, 1 new clinical research unit 23 new research units, 1 new clinical research unit 3UGA researchers find algal ancestor is key to how deadly pathogens proliferate 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy ... has an expanded team of Regional Pharmaceutical Care ... prescriber offices in their regions, with specific areas ... a variety of Regional Pharmaceutical Care Liaisons specializing ... hepatitis C help prescribers understand all the new ...
(Date:12/19/2014)... 2014 Reports from CDC ... suffer from one or more chronic health conditions - ... can address some of these diseases, but may not ... sufferers face. While implanted nerve stimulation devices today offer ... nerve, which can induce side effects. , To ...
(Date:12/19/2014)... 2014 With only 2 weeks left ... on Sartorius Biohit products . The product specials include ... Electronic Pipette Trade-in Program, and free pipette tips. , ... around the world. They are ideal for lab technicians ... ,     Full volume range of 0.1 uL ...
(Date:12/19/2014)... , Dec. 18, 2014 Relmada Therapeutics, ... for the treatment of chronic pain, announced the results ... "This was a transformational year in Relmada,s ... future for our company," said Sergio Traversa , ... we have executed on key financial, human resource and ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... CryoLife, Inc. (NYSE: CRY ),a biomaterials, medical ... A. Theodore has been named vice president, general,counsel, ... directly to,Steven G. Anderson, chairman, president and chief ... Mr. Theodore will be responsible for all corporate,legal ...
... Dr. Andreas Krause to Present on Statistical Considerations for Model, ... and Simulation ... ... (OTC Bulletin Board: PHST), a leading provider of software and,strategic ...
... The 100 Most-Promising Private Technology Ventures Celebrated at Event in ... ... Sept. 3 /Xinhua-PRNewswire/ -- Red Herring,Magazine announced that the leading China ... winner of the,prestigious ,Red Herring 100 Asia, 2007 awards. The news ...
Cached Biology Technology:CryoLife Names Philip Theodore as Vice President, General Counsel 2Pharsight to Present at ROeS Seminar in Bern, Switzerland on September 10 & 11, 2007 2Pharsight to Present at ROeS Seminar in Bern, Switzerland on September 10 & 11, 2007 3Miaxis Biometrics Named as 'Red Herring 100 Asia' Award Winner for 2007 2Miaxis Biometrics Named as 'Red Herring 100 Asia' Award Winner for 2007 3
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
...
Anti-G-alpha-i 1 G-Protein Host: mouse monoclonal Species Reactivity: human, mouse, rat Applications: WB Storage: 4C...
oligophrenin-1 (H-100)...
Biology Products: