Navigation Links
Virus infection may trigger unusual immune cells to attack nerves in multiple sclerosis
Date:6/11/2010

l as the "tripping" mechanisms that defeat it.

In their most recently published study, her research team genetically engineered mice that over-produce a certain type of white blood cell from a group known as killer T cells. The normal function of killer cells is to attack tumor cells or cells infected with viruses or other pathogens. These T cells have receptors that recognize specific proteins that infected cells display to them, much like holding up a target in a window.

The specific killer T cells examined in this study were CD8+ T cells. The Goverman lab engineered mice to over-produce CD8+cells that recognized myelin basic protein, a predominant protein in the myelin sheath that covers nerves. The major question investigated in the study was whether the genetically engineered mice would exhibit a disease that resembled multiple sclerosis.

The researchers infected the mice with a virus that has itself been engineered to produce myelin basic protein. This infection should activate the CD8+T cells to first attack the virally infected cells making myelin basic protein to eliminate the virus, then kill other cells that make myelin basic protein to wrap around nerves. Killing those cells would destroy the myelin sheath.

As expected, the mice developed a multiple sclerosis-like disease. But the researchers were surprised when viruses lacking the myelin basic protein also triggered the disease.

Additional cross-breeding experiments revealed the existence of two receptors on a few of the CD8+T cells. These cells, engineered specifically to bind to myelin basic protein, also built their own receptors for viruses, and could recognize both. When exposed to cells infected with viruses, they would bind to and destroy them using one receptor. Geared up as if they were beserk, some of these double-agent cells then would head elsewhere to bind their other receptor to cells producing myelin basic protein and ruin the coats on ner
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Features of replication suggest viruses have common themes, vulnerabilities
2. First all-African GM crop is resistant to maize streak virus
3. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
4. Gamma globulin effective in treating eye infections caused by adenoviruses
5. Discovery may help defang viruses
6. Who will recover spontaneously from hepatitis C virus infection
7. Prions and retroviruses -- an unholy alliance?
8. Scientists learn structure of enzyme in unusual virus
9. UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC
10. New field-deployable biosensor detects avian influenza virus in minutes instead of days
11. Depression, aging, and proteins made by a virus may all play role in heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Virus infection may trigger unusual immune cells to attack nerves in  multiple sclerosis
(Date:8/28/2014)... a handful of bacterial culprits that may drive inflammatory ... colitis, using patients, own intestinal immune responses as a ... the journal Cell . , Trillions of bacteria ... critical role in the development and progression of IBD. ... bacterial species affect a person,s susceptibility to IBD and ...
(Date:8/28/2014)... researcher and his collaborators have developed an online analytic ... of re-engineering cells for biomedical investigation. CellNet is a ... aid stem cell engineering. Details of CellNet and its ... back-to-back papers in the journal Cell . , ... for all types of cell-based investigations and can potentially ...
(Date:8/28/2014)... Aug. 28, 2014  Privacy Advocate and Senior Staff ... Lynch , joins the lineup of biometric and mobile ... Biometrics UnPlugged Executive Summit in Tampa, Florida ... Previously announced speakers include Steven Rahman, Director, Technology and Strategy ... at Experian. The theme of this year,s event is ...
Breaking Biology News(10 mins):Yale study identifies possible bacterial drivers of IBD 2New tool aids stem cell engineering for medical research 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2
... Chemical changes in tree leaves subjected to warmer, drier ... the availability of soil nutrients, according to a Purdue ... forestry and natural resources, found that red maple leaves ... hot, droughtlike conditions. Those tannins, which defend leaves from ...
... A very simple bench-top technique that uses the ... of 3D structures will benefit the rapidly expanding ... cloaks." Metamaterials are artificial materials that are ... Thesematerials usually gain their unusual propertiessuch as negative ...
... CORVALLIS, Ore. The long-standing conflicts over nuclear power ... in fact, the debate over the damaged Fukushima Dai-Ichi plant ... agencies and the public since 1945, according to an Oregon ... Jacob Hamblin is the author of the 2008 book, "Poison ...
Cached Biology News:Drought-exposed leaves adversely affect soil nutrients, study shows 2Force of acoustical waves tapped for metamaterials 2Historian says history of nuclear power needs to be addressed 2
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)...  Next month, executives from clinical trial marketing firm BBK ... with Patient-Centered Clinical Trials 2014 , to be held ... , September 4-5. Patient recruitment experts Bonnie A. Brescia ... will share insights on the benefits of employing an effective ... from media to mobile apps – can be used to ...
(Date:8/28/2014)... 2014  Armetheon, Inc. ( www.armetheon.com ), a ... late-stage cardiovascular drug candidates, today announced that it ... of financing. The Series A round was co-led ... participation from investors that included Atheneos Capital and ... Larry Hsu , the founder of Impax Laboratories. ...
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3BBK Worldwide Leads Sessions at Key September Events 2Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3
... LONDON, May 6, 2011 Trimega Laboratories is ... European Business Awards, sponsored by HSBC, to represent the United ... Trimega,s pioneering use of dual testing of hair ... Trimega Laboratories, said: "We are thrilled to be selected to ...
... May 6, 2011 Last week in Alexandria, VA, ... of Grants and Acquisition Policy and Accountability (OGAPA) recognized ... its Niche Assessment Program) for a special "team" recognition ... in bringing their applications to market and "contributing to ...
... Researchers in the Materials Science and Technology division ... electrical injection, detection and precession of spin accumulation ... technology, at temperatures up to 225 degrees Celsius. ... accumulation in Si is viable as a basis ...
Cached Biology Technology:Trimega Laboratories to Represent UK in Europe's Most Competitive Business Awards Competition 2Larta Institute Receives Award for National Institutes of Health Commercialization Assistance Program at 2011 Acquisition, Grants, and Small Business Symposium 2NRL scientists achieve high temperature milestone in silicon spintronics 2NRL scientists achieve high temperature milestone in silicon spintronics 3
... Labsystems' Wellwash AC is the ... washer available, and is provided ... wash, waste and rinse bottles. ... automatic rinsing and priming functions ...
... polyclonal to MLF1 Interacting Protein/PBIP1 (phospho ... tested applications). Antigen: ... amino acids 73-83 of Human MLF1 ... Gene ID: 359815 ...
... These handy dispensers save space ... hats, and other garb. They are ... small parts used in labs, processing ... static charges and the particles they ...
... dispensers save space and organize ... and other garb. They are ... for small parts used in ... acrylic. Many other sizes and ...
Biology Products: