Navigation Links
Virus 'explorers' probe inner workings of the brain
Date:6/28/2010

r Oren Kobiler, a postdoctoral research fellow in Enquist's lab, is incorporating into its genetic material a cell-marking technique known as Brainbow. The technology was developed at Harvard University by a research team led by Jean Livet, Joshua Sanes and Jeff Lichtman, and first reported in a 2007 issue of the journal Nature. Brainbow works by inserting into neurons three genes that direct the production of blue, green and red fluorescent proteins. There are some 90 possible hues that can be made from different combinations of the blue, green and red proteins, and the color of a given neuron is determined by the specific amount of each color being made by the cell.

The Brainbow technique also incorporates into neurons a genetic mechanism that randomly mixes and matches the genes that direct the production of the blue, green and red proteins. This shuffling system is activated by the presence of a protein called CRE, which causes neurons that produce CRE to turn different colors from other neurons around them.

By inserting Brainbow into a virus, the research team is hoping to design a viral tracer with capabilities that exceed conventional viral tracers being used today, he explained. Current tracers are able to map out entire circuits, but they cannot distinguish among different sections within a given circuit.

Enquist and his collaborators are using genetic engineering techniques to direct certain neurons, such as those that control a particular body function, to produce CRE. When the neurons that have been engineered to make CRE are infected by the new viral tracer, they will be different colors from infected neurons that are not making CRE. This will allow the researchers to see different subcircuits in the brain, Enquist explained.

For example, he is working with J. Patrick Card, a neuroscientist at the University of Pittsburgh, to make neurons in the brainstem involved in blood pressure regulation in mice produce CRE. W
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Features of replication suggest viruses have common themes, vulnerabilities
2. First all-African GM crop is resistant to maize streak virus
3. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
4. Gamma globulin effective in treating eye infections caused by adenoviruses
5. Discovery may help defang viruses
6. Who will recover spontaneously from hepatitis C virus infection
7. Prions and retroviruses -- an unholy alliance?
8. Scientists learn structure of enzyme in unusual virus
9. UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC
10. New field-deployable biosensor detects avian influenza virus in minutes instead of days
11. Depression, aging, and proteins made by a virus may all play role in heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... YORK , July 21, 2015 ... systems, as seen in the recent U.S. Office ... a solution to the infosec conundrum, but developers ... is stored. To address this dilemma, Biometrics-as-a-Service provider ... its Biometric Tokenization SDK for third party integration. ...
(Date:7/9/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/98rrmr/biometrics_for ... "Biometrics for Banking; Market & Technology Analysis, Adoption ... offering. The adoption for banking purposes ... the forecast is that by 2020 it will ... in delivering biometric systems to the banking industry. ...
(Date:7/8/2015)... 8, 2015  Trovagene, Inc. (NASDAQ: TROV ... announced the launch of a study that aims ... Monitoring℠ (PCM) technology for predicting response to treatment ... combination of the novel immunotherapy agents Yervoy® (ipilumumab), ... inhibitor. The 50-patient study will be led by ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4
... 15, 2011) A study of Canadian home-care patients suggests ... care at home. The study, published in the June issue ... of the Society for Healthcare Epidemiology of America, suggests that ... patients to avoid misuse that could decrease the efficacy of ...
... called "the Manhattan Project of Entomology," an undertaking that ... about insects. The i5k Initiative, also known ... with a letter to Science ( http://www.sciencemag.org/content/331/6023/1386.citation ... Hoc Launch Group. Now the latest issue of ...
... your partner to watch her weight is not recommended-unless you,re ... Proceedings of the Royal Society B . Cleaner fish ... fish. While providing this cleaning service, cleaners may get greedy ... by cleaners causes mealtimes to come to an abrupt end ...
Cached Biology News:Study hints at antibiotic overuse in home-care patients 2Entomologists launch the 5,000 Insect Genome Project (i5k) 2Entomologists launch the 5,000 Insect Genome Project (i5k) 3Fish weight-watchers 2
(Date:7/28/2015)... ... ... 530 sample changer for vials can be used with Anton Paar density meters, viscometers ... mPas (internal air) up to 36,000 (external air) – and can process up to 71 ... is its removable magazine, which is easily lifted off its hub and carried by hand ...
(Date:7/28/2015)... , July 21, 2015 ... has announced the addition of the "Analysis ... report to their offering. Globally, flow ... including immuno-phenotyping, cell proliferation, cancer, and stem cells. ... clinical applications primarily because of demand from underdeveloped ...
(Date:7/28/2015)... DIEGO , July 28, 2015  Kerastem Technologies ... approval from the U.S. FDA Center For Biologics Evaluation ... Therapies to conduct a clinical trial investigating the safety ... of female and early male pattern baldness (androgenic alopecia). ... STYLE trial, follows initial clinical work in ...
(Date:7/28/2015)... SILVER SPRING, Md. and RESEARCH TRIANGLE PARK, N.C., ... UTHR ) today announced its financial results for ... "Orenitram ®  sales grew nearly 300% as compared ... product was first launched," said Roger Jeffs, Ph.D., ... growth in Orenitram sales was due to an ...
Breaking Biology Technology:New Moves in Automatic Sample Handling: Introducing Xsample 530 2Analysis of the Global Flow Cytometry Market 2012-2018 with a 2014 Base Year and a 2015-2018 Forecast Period 2Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 11
... CITY, Calif., July 2 Pearl Therapeutics, Inc.,a ... announced that it has completed the closing of ... executed as an extension to,its first venture financing, ... round were Pearl,s existing investors Clarus Ventures, New ...
... July 2 Schering-Plough,Corporation (NYSE: SGP ... its,previously announced transaction with Virbac, S.A. to ... divestments were requested by the,European Commission as ... the,acquisition of Organon BioSciences N.V., In ...
... To effectively measure,customer satisfaction, follow-up CSR phone ... 5 among customer service and call center executives,in ... LLC,s GLOBAL,BENCHMARKING COUNCIL., However, only 35 percent ... the study,s health care segment not using follow-up ...
Cached Biology Technology:Pearl Therapeutics Closes $18 Million Financing Round Led By Committed Investors 2Schering-Plough Announces Closing of Planned Divestiture of Selected Animal Health Products 2Follow-up Phone Surveys: Effective Customer Service Assessment Tool for Improving Satisfaction 2
... to JAK2 (phospho Y1007) ( Abpromise ... Antigen: Synthesized phosphopeptide ... phosphorylation site of tyrosine 1007 (K-E-Y ... Gene ID: 3717 ...
... Perm Buffer III ... following fixation of PBMCs ... for staining for intracellular ... markers simultaneously. Applications: ...
Cytofix/Cytoperm Kit 250 Tests...
The BD PhosFlow Fix Buffer I can be used for the simultaneous fixation and permeabilization of cells prior to intracellular staining. Applications: Intracellular Staining (Flow) Storage Temperature:...
Biology Products: