Navigation Links
Virus 'explorers' probe inner workings of the brain
Date:6/28/2010

Imagine an exceedingly complex circuit board. Wires often split -- seemingly at random -- and connect in strange and unexpected ways.

This is how Princeton University researchers developing a new method for studying brain connectivity see the brain.

Because of its intricate organization, figuring out the wiring diagram that explains how the billions of neurons in the brain are connected, and determining how they work together, remains a formidable task. But success in this endeavor could transform the field of neuroscience, offering a map toward increased knowledge of how the brain works, with implications for learning more about conditions ranging from depression and schizophrenia to Alzheimer's and Parkinson's disease.

Funded by a $993,000 National Institutes of Health Challenge Grant through the American Recovery and Reinvestment Act, Lynn Enquist, a professor in Princeton's Department of Molecular Biology and in the Princeton Neuroscience Institute, is leading an effort to use genetically engineered viruses as explorers that travel throughout the nervous system, tracing the connections between neurons and reporting on their activity along the way.

"Over the years, the understanding of how cells in the brain are connected has been a major problem," said Enquist, Princeton's Henry L. Hillman Professor in Molecular Biology. "How can this blob of tissue do everything? We're missing a lot of information about how the brain works."

The NIH-funded project hinges on the creation and use of a genetically engineered virus that causes neurons to produce colorful fluorescent proteins. As the virus spreads, it leaves a colorful path through the brain in its wake. Some of the engineered viruses are designed to make the neurons glow brightly when they are active, like an "On Air" sign in the brain.

"These DNA-based technologies allow us to put little labels on neurons that tell who they are connected to," said team
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Features of replication suggest viruses have common themes, vulnerabilities
2. First all-African GM crop is resistant to maize streak virus
3. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
4. Gamma globulin effective in treating eye infections caused by adenoviruses
5. Discovery may help defang viruses
6. Who will recover spontaneously from hepatitis C virus infection
7. Prions and retroviruses -- an unholy alliance?
8. Scientists learn structure of enzyme in unusual virus
9. UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC
10. New field-deployable biosensor detects avian influenza virus in minutes instead of days
11. Depression, aging, and proteins made by a virus may all play role in heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... GOTHENBURG, Sweden , May 18, 2015 ... touch fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from ... place from June until and including Q3 2015 and the ... Asia . Communicated order values for 2015 hereby amount ... revenues for Q1 2015 of 140 MSEK and a number ...
(Date:5/11/2015)... -- Through a well-rounded UAS delegation representing private industry, government, and ... at AUVSI,s Unmanned 2015 conference last week in ... UAS industry met with over 200 hundred people from ... UAS ecosystem. "Our message is clear and ... Rich Knoll . "If you want to fly UAS, ...
(Date:5/7/2015)... GOTHENBURG, Sweden , May 7, 2015 /PRNewswire/ ... new touch fingerprint sensors, FPC1022 and FPC1035, FPC,s ... FPC1022 and FPC1035 are mainly considered for integration ... decreased size gives smartphone OEMs increased possibilities to ... portfolio. The decreased size also improves possibilities for ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... United States Patent and Trademark Office today awarded St. ... St. Jude,s invention of compositions for genetically modifying human ... most common forms of cancer in children and adults. ... cells to recognize and attack certain cells that cause ...
... researchers at the University of Massachusetts Amherst led by ... Geobacter sulfurreducens conducts electricity very effectively along ... the idea of such a novel biological electron transfer ... Geobacter ,s behavior represents a paradigm shift. It goes ...
... 2013) A team of researchers in Seoul, Korea ... in that they regenerate annually - contain multipotent stem ... veterinary medicine. The study appears as an early ... is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0897seo . ...
Cached Biology News:St. Jude Children's Research Hospital announces issuance of US patent for cancer therapy 2UMass Amherst researchers reveal mechanism of novel biological electron transfer 2UMass Amherst researchers reveal mechanism of novel biological electron transfer 3Cell Transplantation study finds stem cells in deer antler 2
(Date:5/28/2015)... 28, 2015 CD-adapco, the largest ... software, announced today it is joining the consortium ... provide state-of-the-art engineering simulation tools for analyzing particle ... and experiences in analyzing particle flow that will ... advance the understanding of flow modeling solutions. , ...
(Date:5/28/2015)... York, NY (PRWEB) May 28, 2015 ... renewed and enhanced its long term partnership with PTI ... work together to provide clients with custom-tailored method ... the art instruments currently available. The agreement includes a ... companies’ employees across organizational lines. This enables a ...
(Date:5/28/2015)... Dr. Carl Peck, MD, Chairman ... L. Williams, MD, has joined the firm as ... are top tier consultants whose expertise and professional ... the company’s clients. Premier Experts collaborate to design ... develop their medical products, pursue optimal regulatory pathways, ...
(Date:5/27/2015)... , May 27, 2015  The Companion ... comprehensive understanding and unprecedented access to the partnering ... leading healthcare companies during 2014. Using ... insight into the partnering activities of the past ... all the partnering and alliances deals announced worldwide.The ...
Breaking Biology Technology:CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2Companion Diagnostics Deals and Alliances of 2014 2
... OriGene Technologies, Inc.,announces its flagship products, TrueORF ... fluorescence protein) vector, enabling easy transfection,monitoring and protein ... reading frame) clones and 12,000 mouse ORF clones ... October, the 2008 Nobel Prize in chemistry was ...
... 31 SleepQuest has always,followed the essence of its ... and unexplained health problems related to lack of sleep., ... of identifying and treating sleep disorders. Sleep is a,cornerstone ... wellness factor.,Studies done by the National Commission on Sleep ...
... Biosciences now offers,the LI-COR Blot Washer for automating ... addition for Western blots. Providing consistent,reproducible incubation and ... Blot Washer is an easy to use liquid ... Up to 20 presets can,be stored in the ...
Cached Biology Technology:OriGene Announces 37,000 ORF cDNA Clones in a GFP Vector 2SleepQuest Tireless in Pursuit of Good Sleep 2LI-COR Blot Washer Automates Western Blot Processing 2
HyPro 20 system for slide hybridization. 20 slide capacity. Active vibration system, slide rack and humidity chamber. Ideal for microarray and in situ hybridization....
... interferons are cytopathic effect inhibition assays, also known ... include; tissue culture supernatents; serum from PK studies ... unit is defined as the quantity of interferon ... of viral infection by 50%. All ...
Request Info...
... Nebulizers are available in two product models - ... two models is that the 6000AT+ includes a ... drier aerosol for improved detection limits and reduced ... a range of elements by 10-40 times. Note ...
Biology Products: