Navigation Links
Virus 'barcodes' offer rapid detection of mutated strains
Date:5/13/2012

Dr Julian Hiscox and Dr John Barr of the University's Faculty of Biological Sciences are working with the Health Protection Agency Porton (HPA) to build a bank of molecular signatures that will help identify the severity of virus infection from characteristic changes seen in cells. Currently the team is barcoding different strains of influenza virus and human respiratory syncytial virus (HRSV) - a virus associated with the onset of asthma in young children.

"Diseases such as flu infect and hijack our cells, turning them into virus producing factories," says Dr Hiscox. "The infection causes the balance of proteins in a cell to change - some proteins are overproduced and others suppressed. Which proteins are affected and by how much varies depending on the type of virus, allowing us to identify a unique barcode of disease for each."

The research, published today (14 May) in Proteomics, investigates changes in lung cells infected with swine flu from the 2009 outbreak compared with seasonal flu. The team used a labelling technique called SILAC to measure and compare thousands of different proteins in a sample.

This technique was used alongside mass spectrometry to identify the proteins most affected by viral infection and used these as molecular signatures to provide the 'barcode' of disease. The paper reports how several processes in the cell were affected by the virus, with most changes seen in proteins involved in cell replication.

"Swine flu affects the lungs in a similar way to seasonal flu and this was reflected in the barcodes we found for each," explains Dr Barr. "Using this test might have been a way to identify how lethal the 2009 swine flu pandemic was going to be, lessening worldwide panic.

"Our next step is to test more lethal strains of flu, such as bird flu, to see how the barcodes differ. Flu virus frequently mutates, resulting in new strains which may be life-threatening and become pandemic. If we can test new strains using our method, we can determine their potential impact on health by comparing their barcode of disease to those of viruses already studied."

The group from Leeds has already barcoded two types of HRSV which can cause severe respiratory disease in young children. Co-author Professor Miles Carroll of HPA Porton says: "We have focused our work on common respiratory viruses, such as flu and HRSV, but this method could be applied to a wide variety of viruses, including tropical diseases that are prone to sudden outbreaks and can be lethal."


'/>"/>
Contact: Dr Julian Hiscox
j.a.hiscox@leeds.ac.uk
44-113-343-5582
University of Leeds
Source:Eurekalert

Related biology news :

1. Berkeley Lab scientists generate electricity from viruses
2. BGI, GMU, Mass. Eye and Ear and OUHSC announce agreement to sequence 100 human adenoviruses
3. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
4. Researchers identify Achilles heel of dengue virus, target for future vaccines
5. Harmless human virus may be able to boost the effects of chemotherapy
6. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
7. To drive infections, a hijacking virus mimics a cells signaling system
8. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
9. Studies reveal structure of EV71, a virus causing childhood illnesses
10. Oncolytic virus extends survival in medulloblastoma model
11. Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... , February 3, 2016 ... market research report "Automated Fingerprint Identification System Market by ... Search), Application (Banking & Finance, Government, Healthcare, and Transportation) ... MarketsandMarkets, the market is expected to be worth USD ... 21.0% between 2015 and 2020. The transformation and technology ...
(Date:2/2/2016)... 2016  BioMEMS devices deployed in hospitals ... medical screening and diagnostic applications, such as ... that facilitate and assure continuous monitoring without ... being bolstered through new opportunities offered by ... coupled with wireless connectivity and low power ...
(Date:2/2/2016)... , Feb. 2, 2016 Technology Enhancements Accelerate Growth ... analysis of the digital and computed radiography markets in ... , and Indonesia (TIM). It ... market size, as well as regional market drivers and ... discusses market penetration and market attractiveness, both for digital ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 2016 - New FDA action date of ... FDA action date of July 22, 2016   ... 22, 2016   - Lifitegrast has ... indicated for the treatment of signs and symptoms of dry eye ... potential to be the only product approved in the U.S. in the past decade indicated ...
(Date:2/4/2016)... ... ... Shimadzu Scientific Instruments will showcase several new products, including ... and present on the analysis of mycotoxins and medical cannabis at the Pittcon ... the Georgia World Congress Center in Atlanta, Georgia. , Attendees should stop ...
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, the ... medical institutions attended a ceremony in late 2015 to ... cell therapy in 2016. --> ... Translation Platform for Personalized Cell Therapy" was hosted by ... Production Center, both subsidiaries of Beike Biotechnology Co., Ltd. ...
(Date:2/4/2016)... and MENLO PARK, Calif. , Feb. ... ("DelMar" and the "Company"), a biopharmaceutical company focused on the ... it will present at the 18 th Annual ... 2016 at 10:00 a.m. EST in New York, ... president and CEO, will provide an update on the ongoing ...
Breaking Biology Technology: