Navigation Links
Virus 'barcodes' offer rapid detection of mutated strains
Date:5/13/2012

Dr Julian Hiscox and Dr John Barr of the University's Faculty of Biological Sciences are working with the Health Protection Agency Porton (HPA) to build a bank of molecular signatures that will help identify the severity of virus infection from characteristic changes seen in cells. Currently the team is barcoding different strains of influenza virus and human respiratory syncytial virus (HRSV) - a virus associated with the onset of asthma in young children.

"Diseases such as flu infect and hijack our cells, turning them into virus producing factories," says Dr Hiscox. "The infection causes the balance of proteins in a cell to change - some proteins are overproduced and others suppressed. Which proteins are affected and by how much varies depending on the type of virus, allowing us to identify a unique barcode of disease for each."

The research, published today (14 May) in Proteomics, investigates changes in lung cells infected with swine flu from the 2009 outbreak compared with seasonal flu. The team used a labelling technique called SILAC to measure and compare thousands of different proteins in a sample.

This technique was used alongside mass spectrometry to identify the proteins most affected by viral infection and used these as molecular signatures to provide the 'barcode' of disease. The paper reports how several processes in the cell were affected by the virus, with most changes seen in proteins involved in cell replication.

"Swine flu affects the lungs in a similar way to seasonal flu and this was reflected in the barcodes we found for each," explains Dr Barr. "Using this test might have been a way to identify how lethal the 2009 swine flu pandemic was going to be, lessening worldwide panic.

"Our next step is to test more lethal strains of flu, such as bird flu, to see how the barcodes differ. Flu virus frequently mutates, resulting in new strains which may be life-threatening and become pandemic. If
'/>"/>

Contact: Dr Julian Hiscox
j.a.hiscox@leeds.ac.uk
44-113-343-5582
University of Leeds
Source:Eurekalert

Page: 1 2

Related biology news :

1. Berkeley Lab scientists generate electricity from viruses
2. BGI, GMU, Mass. Eye and Ear and OUHSC announce agreement to sequence 100 human adenoviruses
3. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
4. Researchers identify Achilles heel of dengue virus, target for future vaccines
5. Harmless human virus may be able to boost the effects of chemotherapy
6. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
7. To drive infections, a hijacking virus mimics a cells signaling system
8. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
9. Studies reveal structure of EV71, a virus causing childhood illnesses
10. Oncolytic virus extends survival in medulloblastoma model
11. Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Global Wearable Technologies Market ... Share, Overview, Trends and Forecast 2014-2020" report ... Technologies are smart devices that can be worn ...
(Date:12/24/2014)... Dec. 23, 2014  Since its launch in December 2014, the ... the pain of trying to remember their usernames and passwords ... to their smartphones. To assist people who have struggled to ... that created 1U and focuses on redefining identity, announced today ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season ... as Acuity Market Intelligence reports that the long anticipated ... forecasts that intensifying demand for smart phones, tablets, and ... global market of 2.5 billion users with nearly 4.8 ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... SITUATION: The largest living structures on Earth ... at risk, the most definitive review yet of the impact ... In a paper published in the prestigious Science Magazine today, ... race against time in preparing coral reefs and the coastal ...
... A pioneering study of wild chimpanzees has found that ... rebutting previous studies of captive individuals which had postulated ... 40 years of age. Together with recent data ... this week in the journal Current Biology -- suggests ...
... and Johns Hopkins University have uncovered another reason why ... is so dangerous. As reported in Nature Genetics ... of at least 13 microRNAs, small pieces of nucleic ... and off. Furthermore, in several instances, re-introducing repressed miRNAs ...
Cached Biology News:It's official: The carbon crisis is lethal for coral reefs 2It's official: The carbon crisis is lethal for coral reefs 3It's official: The carbon crisis is lethal for coral reefs 4Wild chimpanzees appear not to regularly experience menopause 2University of Pennsylvania researchers zero in on the tiniest members in the war on cancer 2
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... (NYSE: MDT ) has submitted a pre-market ... (FDA) for the use of Medtronic,s SynchroMed ® ... catheter) for use with United Therapeutics, Remodulin ® ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by ... Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, End ... to 2019” provides a detailed overview of the ... and strategies impacting the preparative and process chromatography ...
(Date:12/24/2014)... December 23, 2014 On Friday, December ... the Omnibus and Continuing Resolution Appropriations Act of 2015, ... eligible to receive funding through the Congressionally Directed Medical ... (DoD). The Hydrocephalus Association (HA), working in conjunction with ...
Breaking Biology Technology:Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... overwhelming perspective on the biotech industry that says it has ... pump billions of research dollars without any return. As we ... trade on earnings like Big Pharma companies; they trade on ... 2005 sales and earning results are still not out for ...
... materials used to display information on cell phones, monitors ... report in real time on the differentiation of embryonic ... which embryonic stem cells gradually turn into function-specific types ... heart or brain cells. , ,The main challenge facing ...
... Can a Mac really be hacked in just 30 minutes? ... systems engineer, who criticized recent media reports for sensationalism after they ... of a computer gave out login accounts to potential hackers. , ... had been given access to the computer to take full control ...
Cached Biology Technology:The world's leading biotech companies 2The world's leading biotech companies 3Liquid crystals show promise in controlling embryonic stem cells 2