Navigation Links
Virus 'barcodes' offer rapid detection of mutated strains
Date:5/13/2012

Dr Julian Hiscox and Dr John Barr of the University's Faculty of Biological Sciences are working with the Health Protection Agency Porton (HPA) to build a bank of molecular signatures that will help identify the severity of virus infection from characteristic changes seen in cells. Currently the team is barcoding different strains of influenza virus and human respiratory syncytial virus (HRSV) - a virus associated with the onset of asthma in young children.

"Diseases such as flu infect and hijack our cells, turning them into virus producing factories," says Dr Hiscox. "The infection causes the balance of proteins in a cell to change - some proteins are overproduced and others suppressed. Which proteins are affected and by how much varies depending on the type of virus, allowing us to identify a unique barcode of disease for each."

The research, published today (14 May) in Proteomics, investigates changes in lung cells infected with swine flu from the 2009 outbreak compared with seasonal flu. The team used a labelling technique called SILAC to measure and compare thousands of different proteins in a sample.

This technique was used alongside mass spectrometry to identify the proteins most affected by viral infection and used these as molecular signatures to provide the 'barcode' of disease. The paper reports how several processes in the cell were affected by the virus, with most changes seen in proteins involved in cell replication.

"Swine flu affects the lungs in a similar way to seasonal flu and this was reflected in the barcodes we found for each," explains Dr Barr. "Using this test might have been a way to identify how lethal the 2009 swine flu pandemic was going to be, lessening worldwide panic.

"Our next step is to test more lethal strains of flu, such as bird flu, to see how the barcodes differ. Flu virus frequently mutates, resulting in new strains which may be life-threatening and become pandemic. If
'/>"/>

Contact: Dr Julian Hiscox
j.a.hiscox@leeds.ac.uk
44-113-343-5582
University of Leeds
Source:Eurekalert

Page: 1 2

Related biology news :

1. Berkeley Lab scientists generate electricity from viruses
2. BGI, GMU, Mass. Eye and Ear and OUHSC announce agreement to sequence 100 human adenoviruses
3. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
4. Researchers identify Achilles heel of dengue virus, target for future vaccines
5. Harmless human virus may be able to boost the effects of chemotherapy
6. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
7. To drive infections, a hijacking virus mimics a cells signaling system
8. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
9. Studies reveal structure of EV71, a virus causing childhood illnesses
10. Oncolytic virus extends survival in medulloblastoma model
11. Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... --   3D scanner developer ... Fuel3D , a developer of 3D scanning solutions, today ... million (£4 million). This funding builds on the company,s initial ... paves the way for the commercial launch of the company,s ... was led by Chimera Partners and will be used to ...
(Date:11/4/2014)...   Neurotechnology , a provider of high-precision ... version of its fingerprint matching algorithm has achieved ... evaluation organized by NIST. The MINEX test measures ... 378 fingerprint standard template format. MINEX compliance is ... the United States and ...
(Date:11/3/2014)... of Colorado Cancer Center study published in ... Sciences describes the activity of a recently discovered ... or IL-37. It has been known to limit inflammation ... adaptive immune system: IL-37 inhibits the ability of the ... "Knowing this mechanism that underlies IL-37,s effect on the ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
... 2009)A minimally invasive interventional radiology treatmentthat safely and ... herniated diskswill become standard in the United States ... the Society of Interventional Radiology,s 34th Annual Scientific ... examined just how ozone relieves the pain associated ...
... once a week displayed higher cognitive skills at the age of ... a study of nearly 4,000 teenagers published in the March issue ... a week was enough to increase combined, verbal and visuospatial intelligence ... more than once a week increased them by just under 11 ...
... strokes has taken a significant step forward today (09 ... brain tissue in rats. The team of scientists ... Council (BBSRC) and led by Dr Mike Modo of ... work, carried out at the Institute of Psychiatry and ...
Cached Biology News:Oh, my aching back: Give me a shot of ozone 2Oh, my aching back: Give me a shot of ozone 3Teenage boys who eat fish at least once a week achieve higher intelligence scores 2Teenage boys who eat fish at least once a week achieve higher intelligence scores 3Stem cells replace stroke-damaged tissue in rats 2
(Date:11/26/2014)... , Nov. 26, 2014 Space is ... exploration of space requires astronauts to maintain consistently high ... success, and prevent potential errors and accidents. Despite the ... known about how cognition is affected by prolonged spaceflight, ... Now, Penn Medicine researchers are poised to help ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... announced today that applications for AccelerateBaltimore™ (AB) 2015 ... you have a big idea?,” asked ETC’s President ... about it. AccelerateBaltimore helps you and your big ... 13 weeks.” Interested game changers with “big ...
(Date:11/26/2014)... November 25, 2014 SonaCare Medical, ... Ultrasound (HIFU) devices, recently participated in the American ... Mass 360° .” Key opinion leaders in urology ... related to small renal masses while attendees had ... ablative technologies in hands-on labs. Attendees at the ...
(Date:11/26/2014)... November 25, 2014 The Pittcon marketing ... official conference and exposition mobile app, ... download in the App Store for iOS and Android ... resource tool before, during and after the event. It ... on exhibiting companies, technical sessions, Conferee Networking sessions and ...
Breaking Biology Technology:Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Pittcon Releases 2015 Mobile App 2
... June 23 Replidyne, Inc.,(Nasdaq: RDYN ) today ... with Asubio Pharma Co., Ltd. for faropenem medoxomil (faropenem).,In ... it has,terminated its supply agreement with Asubio Pharma Co., ... These decisions were made as a,result of the Company ...
... Web-based programs give sponsors easy-to-use tools to store, mine ... transfer knowledge base to ensure enrollment success, ... recruitment technology leader, announced the release of a new,product, ... support in-house recruitment capabilities for clinical,trial sponsors. The goal ...
... Ariz., June 23 MedPredict has published ... insight for pharma and,biotech companies hoping to ... The report, entitled "Thought Leader Insight & ... with a panel of,specialists in anesthesiology, psychiatry, ...
Cached Biology Technology:Replidyne Terminates Faropenem Agreements 2Replidyne Terminates Faropenem Agreements 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 2TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 4In Pain Market, Huge Unmet Needs, Tough Regulatory Environment Challenge Pharmaceutical Companies, According to MedPredict 2
GLP-compliant, CLIA-certified DNA sequencing service. ASQ and SQA certified quality assurance staff. Auditors welcome....
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... to human XAB2 (amino terminus) XAB2 ... its interaction with XPA. Immunoprecipitation experiments have ... interacts with the transcription-coupled repair-specific proteins CSA ... polymerase II. Microinjection experiments with XAB2 antibodies ...
... using advanced automated high throughput microplate processing equipment that dispenses ... accommodate virtually any lot size of the following formats (with ... 8 and 12 well strips, ... 384 well microplate, 1536 ...
Biology Products: