Navigation Links
Virus attacks childhood cancers
Date:8/29/2011

Researchers from Yale University are looking to a virus from the same family as the rabies virus to fight a form of cancer primarily found in children and young adults. They report their findings in the September 2011 issue of the Journal of Virology.

Soft tissue sarcomas are cancers that develop in tissues which connect, support, or surround other structures and organs of the body. Muscles, tendons, fibrous tissues, fat, blood vessels, nerves, and synovial tissues are types of soft tissue. While relatively rare in adults, they represent approximately 15% of pediatric malignancies and result in death for approximately one-third of patients within 5 years of diagnosis.

Vesicular stomatitis virus (VSV) is a rhabdovirus, which is the same family of viruses as rabies, and causes a disease similar to foot and mouth disease in cattle. Recent research has discovered that this virus also is oncolytic, meaning it seeks out and destroys cancerous tumors. Previous studies have already shown VSV to be promising in treating brain tumors in mice.

In this study the researchers investigated the potential of VSV and an oncolytically enhanced version of the virus (VSV-rp30a) to effectively target and kill 13 different sarcomas. Both of the viruses efficiently infected and killed 12 of the sarcomas. The resistance of the one surviving sarcoma line was eventually overcome by pretreatment with compounds that antagonize interferon signaling.

Additionally they looked at the ability of VSV-rp30a to infect and arrest tumor growth in mice.

"A single intravenous injection of VSV-rp30a selectively infected all subcutaneous human sarcomas tested in mice and arrested the growth of tumors that otherwise grew 11-fold," say the researchers. "Overall, we find that the potential efficacy of VSV as an oncolytic agent extends to nonhematologic mesodermal tumors and that unusually strong resistance to VSV oncolysis can be overcome with interferon attenuators."


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Single protein, key to ebola virus infection, could aid in drug design
2. Researchers map pathway of infection for a common, potentially life-threatening respiratory virus
3. Software predicted risk in California West Nile virus epidemic
4. Decade-long study reveals recurring patterns of viruses in the open ocean
5. Scientists copy the ways viruses deliver genes
6. Humabs discovers the first antibody to neutralize both group 1 and group 2 influenza A viruses
7. Oral interferon may prevent and control avian influenza virus infection
8. Catching the West Nile virus in action
9. Scavenger cells accomplices to viruses
10. Juvenile diarrhea virus analyzed
11. New laser technology could kill viruses and improve DVDs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Research and Markets has announced the addition of the ... to 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market ... the next decade to reach approximately $14.21 billion by 2025. ... for all the given segments on global as well as regional ...
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
(Date:3/7/2017)... BRIGHTON, England , March 7, 2017 Brandwatch ... been chosen by The Prince,s Trust to uncover insights ... insights across The Trust. The UK,s leading youth charity ... track social campaign results and get a better understanding of the ... ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... 27, 2017 DarioHealth Corp. (NASDAQ: DRIO), a ... big data solutions, today announced that it is now ... for U.S. consumers who want to have their DarioHealth ... signed strategic alliance agreements with partners across the U.S. ... and if approved, will supply and bill the customer,s ...
(Date:3/24/2017)... Research and Markets has announced the addition ... Strategic Business Report" report to their offering. ... This report analyzes the Global ... Annual estimates and forecasts are provided for the period 2014 through ... research. The report profiles 25 companies including many ...
(Date:3/24/2017)... 2017 Agenus Inc. (NASDAQ: AGEN), an immuno-oncology ... cancer vaccines, today announced participation at the following conferences: ... Blair and Maidstone Life Sciences conference "Cancer Immunotherapy Conference" ... New York, NY . Agenus will participate ... 9:40 am: Robert B. Stein , M.D., Ph.D., ...
(Date:3/23/2017)... Md. , March 23, 2017  Northwest ... developing DCVax® personalized immune therapies for solid tumor ... the $7.5 million financing it announced last Friday, ... sold to several institutional investors securities totaling 28,843,692 ... per share, and 10,000,000 shares of Class C ...
Breaking Biology Technology: