Navigation Links
Virus attacks childhood cancers
Date:8/29/2011

Researchers from Yale University are looking to a virus from the same family as the rabies virus to fight a form of cancer primarily found in children and young adults. They report their findings in the September 2011 issue of the Journal of Virology.

Soft tissue sarcomas are cancers that develop in tissues which connect, support, or surround other structures and organs of the body. Muscles, tendons, fibrous tissues, fat, blood vessels, nerves, and synovial tissues are types of soft tissue. While relatively rare in adults, they represent approximately 15% of pediatric malignancies and result in death for approximately one-third of patients within 5 years of diagnosis.

Vesicular stomatitis virus (VSV) is a rhabdovirus, which is the same family of viruses as rabies, and causes a disease similar to foot and mouth disease in cattle. Recent research has discovered that this virus also is oncolytic, meaning it seeks out and destroys cancerous tumors. Previous studies have already shown VSV to be promising in treating brain tumors in mice.

In this study the researchers investigated the potential of VSV and an oncolytically enhanced version of the virus (VSV-rp30a) to effectively target and kill 13 different sarcomas. Both of the viruses efficiently infected and killed 12 of the sarcomas. The resistance of the one surviving sarcoma line was eventually overcome by pretreatment with compounds that antagonize interferon signaling.

Additionally they looked at the ability of VSV-rp30a to infect and arrest tumor growth in mice.

"A single intravenous injection of VSV-rp30a selectively infected all subcutaneous human sarcomas tested in mice and arrested the growth of tumors that otherwise grew 11-fold," say the researchers. "Overall, we find that the potential efficacy of VSV as an oncolytic agent extends to nonhematologic mesodermal tumors and that unusually strong resistance to VSV oncolysis can be overcome with interferon attenuators."


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Single protein, key to ebola virus infection, could aid in drug design
2. Researchers map pathway of infection for a common, potentially life-threatening respiratory virus
3. Software predicted risk in California West Nile virus epidemic
4. Decade-long study reveals recurring patterns of viruses in the open ocean
5. Scientists copy the ways viruses deliver genes
6. Humabs discovers the first antibody to neutralize both group 1 and group 2 influenza A viruses
7. Oral interferon may prevent and control avian influenza virus infection
8. Catching the West Nile virus in action
9. Scavenger cells accomplices to viruses
10. Juvenile diarrhea virus analyzed
11. New laser technology could kill viruses and improve DVDs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 /PRNewswire/ ... leader in dairy research, today announced a new collaboration ... reduce the chances that the global milk supply is ... dairy project, Cornell University has become the newest academic ... Supply Chain, a food safety initiative that includes IBM ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... ... VIC Technology Venture Development™ (VIC™), is pleased to announce that ... continues to strengthen and diversify VIC’s board. , "We are excited to have Jamie ... accomplished business executive with a broad range of experience directly relevant to VIC as ...
(Date:7/20/2017)... Reno, NV (PRWEB) , ... July 20, 2017 ... ... a real solution to make clinical trial sites and study participants truly unified. ... manage regulatory compliant (FDA 21 CFR Part 11) research studies entirely on mobile ...
(Date:7/18/2017)... ... July 18, 2017 , ... ... United States Patent and Trademark Office for its Patent Applications 14/858,857 and 13/669,785 ... allowances of these patent applications further expand the protection of G-CON’s R&D investments ...
(Date:7/17/2017)... ... July 17, 2017 , ... Whitehouse Laboratories is excited to ... the full series of ISO 80369 standard test procedures. The ISO 80369 series ... drug delivery systems. With this recent expansion, Whitehouse Labs becomes one of the ...
Breaking Biology Technology: