Navigation Links
Virginia Tech engineer receives NSF grant to study Colorado flood effects on antibiotic resistance
Date:1/9/2014

The World Health Organization and the Center for Disease Control has recognized antibiotic resistance "as a critical health challenge of our time," said Amy Pruden, a Virginia Tech environmental engineer who is credited with pioneering the concept of antibiotic resistance genes as environmental pollutants.

Pruden said reducing the spread of antibiotic resistance is a critical measure needed to prolong the effectiveness of currently available antibiotics. This is important since "new drug discovery can no longer keep pace with emerging antibiotic-resistant infections," Pruden said.

Pruden is a 2006 National Science Foundation (NSF) CAREER award recipient as well as a 2007 Presidential Early Career Award in Science and Engineering (PECASE) honoree.

Pruden's unique expertise in characterizing environmental sources and pathways of antibiotic resistance has garnered her as lead of a new NSF RAPID grant to study the recent Colorado flood's effect on antibiotic resistance genes. She will work with Mazddak Arabi of Colorado State University and Diana Aga of the University of Buffalo on the project that will improve the understanding of the role the watershed processes play in disseminating resistance.

For more than 10 years, this research team has monitored the watershed of the South Platte River Basin, southwest of Denver, Colo. "We have already generated a robust data set of antibiotic resistance genes and antibiotics, as well as a unique interdisciplinary watershed-scale approach for characterizing the land-use on their distribution," Pruden explained.

The recent Colorado flooding occurred during the week of Sept. 9, 2013, with flood waters affecting 17 counties over a spread of 200 miles north to south, transporting enormous loads of sediment and transforming the semi-arid landscape of the Front Range of Colorado.

When an antibiotic is consumed, researchers have learned that up to 90 percent passes through a body without metabolizing. This means the drugs can leave the body almost intact through normal bodily functions.

In the case of agricultural areas, excreted antibiotics can then enter stream and river environments through a variety of ways, including discharges from animal feeding operations, fish hatcheries, and nonpoint sources such as the flow from fields where manure or biosolids have been applied. Water filtered through wastewater treatment plants may also contain used antibiotics.

Consequently, these releases become "potential sources of antibiotic resistance genes," said Pruden.

The overall goal of their new research grant is to take advantage of the knowledge gained from the flooding in Colorado to help clarify what mechanisms control the fate and transport of antibiotic resistance genes originating from wastewater treatment plants and animal feeding operations in the watershed.

"Our overarching hypothesis is that two main mechanisms drive antibiotic resistance gene dissemination: selection by antibiotics and/or metals and the transport via physical processes such as sediment transport," Pruden said.

Their method will be to compare the antibiotic resistance elements in water and sediment samples along a defined pristine-urban-agricultural river gradient from before and after the flood. They will also compare antibiotics and metals in water and sediment samples along a defined pristine-urban-agricultural river gradient and examine the correlation with antibiotic resistance genes from before and after the flood.

"We believe our research will have vital implications for the development of effective policy and management practices to prolong the useful lifespan of antibiotics critical to human and animal health," Pruden said.

Emily Lipscomb, of Swanton, Md., an NSF graduate research fellow, will help carry out the project along with assistance from undergraduate students alongside the trio of faculty leading this work.


'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Related biology news :

1. Virginia Techs De Vita receives governments highest of engineering honors to study pelvic disorder
2. Virginia Tech research overturns assumption about mercury in the Arctic
3. Virginia Tech researchers explore natural way to displace harmful germs from household plumbing
4. Widespread but neglected disease a health threat in Africa, Virginia Tech researchers say
5. Biofilms help Salmonella survive hostile conditions, Virginia Tech researchers say
6. Natures phenomena might teach Virginia Tech engineers new tricks
7. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
8. Virginia Tech expands sports concussion-risk studies to include hockey and baseball
9. Virginia Woolf and Neuropsychiatry
10. Virginia Tech computer scientists develop new way to study molecular networks
11. TESARO and Virginia G. Piper Cancer Center announce first patient in clinical trial of TSR-011
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Virginia Tech engineer receives NSF grant to study Colorado flood effects on antibiotic resistance
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer ... what they believe could be a new and helpful biomarker for malignant pleural ... Click here to read it now. , Biomarkers are components in the ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
Breaking Biology Technology: