Navigation Links
Virginia Tech computer scientists develop new way to study molecular networks
Date:1/24/2013

In biology, molecules can have multi-way interactions within cells, and until recently, computational analysis of these links has been "incomplete," according to T. M. Murali, associate professor of computer science in the College of Engineering at Virginia Tech.

His group authored an article on their new approach to address these shortcomings, titled "Reverse Engineering Molecular Hypergraphs," that received the Best Paper Award at the recent 2012 ACM Conference on Bioinformatics, Computational Biology and Biomedicine.

Intricate networks of connections among molecules control the processes that occur within cells. The "analysis of these interaction networks has relied almost entirely on graphs for modeling the information. Since a link in a graph connects at most two molecules (e.g., genes or proteins), such edges cannot accurately represent interactions among multiple molecules. These interactions occur very often within cells," the computer scientists wrote in their paper.

To overcome the limitations in the use of the graphs, Murali and his students used hypergraphs, a generalization of a graph in which an hyperedge can connect multiple molecules.

"We used hypergraphs to capture the uncertainty that is inherent in reverse engineering gene to gene networks from systems biology datasets," explained Ahsanur Rahman, the lead author on the paper. "We believe hypergraphs are powerful representations for capturing the uncertainty in a network's structure."

They developed reliable algorithms that can discover hyperedges supported by sets of networks. In ongoing research, the scientists seek to use hyperedges to suggest new experiments. By capturing uncertainty in network structure, hyperedges can directly suggest groups of genes for which further experiments may be required in order to precisely discover interaction patterns. Incorporating the data from these experiments might help to refine hyperedges and resolve the
'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Virginia Tech announces 2012 football helmet ratings; 2 more added to the 5-star mark
2. Biology professor secures grant to save West Virginias primary natural history collection
3. Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium
4. Scientific meeting at Virginia Tech will make more than $2 million economic impact
5. Old deeds, witness trees offer glimpse of pre-settlement forest in West Virginia
6. TESARO and Virginia G. Piper Cancer Center announce first patient in clinical trial of TSR-011
7. Computer simulations help explain why HIV cure remains elusive
8. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
9. Computer scientists develop an interactive field guide app for birders
10. Computer model pinpoints prime materials for efficient carbon capture
11. 2 NASA visualizations selected for computers graphics showcase
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Virginia Tech computer scientists develop new way to study molecular networks
(Date:8/6/2015)... BOSTON and TELTOW, Germany ... the 2015 Siggraph Conference, SensoMotoric Instruments (SMI) ... augmented reality , based on Epson,s Moverio ... eye tracking platform. With this new solution, unprecedented quality ... multi-modal, hands-free interaction with context-sensitive displays. For the first ...
(Date:8/4/2015)... 2015 Research ... the addition of the "Digital Forensics ... Sub-Segment (Computer Forensics, Network Forensics, Mobile Device ... Vertical and Region - Global Forecast to ... By Component (Hardware, Software, and Service), ...
(Date:7/31/2015)... 2015 A 10 a. Conferência Internacional ... BGI de 22-25 de outubro de 2015, em ... está celebrando seu 10 o. aniversário este ano. Desde ... das reuniões mais influentes do mundo no ramo das ... e prazerosos. A ICG-10 se concentra ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... at the University of California, Riverside has received an education fellowship ... encourage more Hispanic students to take an interest in and perform ... professor in the Department of Botany and Plant Sciences ... has been selected to participate in the 2011 USDA E. ...
... BOSTON (April 29, 2011) A gene therapy approach ... in slowing the signs of age-related macular degeneration (AMD), ... at Tufts University School of Medicine. Led by senior ... first time that CD59 delivered by a gene therapy ...
... , , , , , ... , , ... Several fish can be heard in... , Click here for more information. ... , , , , , , ...
Cached Biology News:Fellowship to UC Riverside botanist encourages Hispanic students to take up research 2Fellowship to UC Riverside botanist encourages Hispanic students to take up research 3Gene therapy shows promise against age-related macular degeneration 2Jump in communication skills led to species explosion in electric fishes 2Jump in communication skills led to species explosion in electric fishes 3Jump in communication skills led to species explosion in electric fishes 4Jump in communication skills led to species explosion in electric fishes 5Jump in communication skills led to species explosion in electric fishes 6Jump in communication skills led to species explosion in electric fishes 7
(Date:8/27/2015)... 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC ... Pharmaceutical Holding Company Limited (Biohaven), announced today that ... of BHV-0223, a glutamate modulating agent. Biohaven filed ... recently obtained clearance from the U.S. Food and ... Portage holds 54% equity interest in Biohaven, a ...
(Date:8/27/2015)... , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... and six-month periods ended June 30, 2015. Biorem,s complete second quarter ... ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended ... 2014 , 2015 , 2014 Revenue ... , 4,433 Gross profit , 1,656 , ...
(Date:8/27/2015)... ... August 27, 2015 , ... Inc. Magazine released its annual ... Solutions as number 1,361 in growth for the three years through 2014. Being named ... fastest-growing privately held organizations in the country. , “We are thrilled to make ...
(Date:8/27/2015)... ... 27, 2015 , ... Proove Biosciences, a commercial and ... of genetics and hypertension at the International Academy of Cardiology Annual ... Canada. The event, which boasts an extensive overview of the latest research developments ...
Breaking Biology Technology:Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3
... CHAPEL HILL, N.C., Nov. 5 As ... market, considerable efforts,are placed on strategy and ... largely focus on revenue growth and little ... launch excellence, a recent study,was conducted by ...
... Assay Designs, Inc., a leading,provider of ... life science,and translational research markets, has announced ... The agreement enables Assay Designs to,distribute approximately ... their U.S. and Canadian customers. This major ...
... N.Y., Nov. 5 Misonix, Inc.,(Nasdaq: MSON ... device,technology, which in Europe is used for the ... conditions, has entered into a new, three,year, exclusive ... Rotterdam, The Netherlands, for the distribution of the,SonaStar(TM) ...
Cached Biology Technology:New Study Provides Key Findings for Biopharma Product Launch Evaluation 2Assay Designs(TM), Inc. Announces Agreement with Abnova Corp. of Taiwan 2Misonix Announces New Distribution Agreement for The Netherlands 2Misonix Announces New Distribution Agreement for The Netherlands 3
... is a bovine protein-free alternative to ... an aqueous solution that contains non-toxic ... (3-(N-Morpholino) propanesulfonic acid), pH 6.0 - ... 0.02% methylisothiazolone and 0.02% bromonitrodioxane as ...
These 96-well 0.2 ml thin-wall PCR plate caps are caps that are used to seal 96-well, 0.2 ml thin-wall PCR plates. Supplied as 300 caps....
... software with the DeCypher Engine accelerator cards to ... perform searches like these from your desktop: ... under 6 days Align BAC-sized queries ... HMM analysis to compare 100,000 sequences to PFAM ...
Mouse monoclonal antibody to FMN2 - formin 2...
Biology Products: