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Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function
Date:6/30/2010

Everyone knows olive oil and a Mediterranean diet are associated with a lower risk for cardiovascular disease, but a new research report published in the July 2010 print issue of the FASEB Journal (http://www.fasebj.org) offers a surprising reason why: These foods change how genes associated with atherosclerosis function.

"Knowing which genes can be modulated by diet in a healthy way can help people select healthy diets," said Maria Isabel Covas, D.Pharm., Ph.D., a researcher involved in the work from the Cardiovascular Risk and Nutrition Research Group at the Institut Municipal d'Investigacio Medica in Barcelona, Spain. "It is also a first step for future nutritional therapies with selected foods."

Scientists worked with three groups of healthy volunteers. The first group consumed a traditional Mediterranean diet with virgin olive oil rich in polyphenols. The second group consumed a traditional Mediterranean diet with an olive oil low in polyphenols. The third group followed their habitual diet. After three months, the first group had a down-regulation in the expression of atherosclerosis-related genes in their peripheral blood mononuclear cells. Additionally, the olive oil polyphenols made a significant impact on the expression of genetic changes influencing coronary heart disease. Results also showed that the consumption of virgin olive oil in conjunction with a Mediterranean diet can positively impact lipid and DNA oxidation, insulin resistance, inflammation, carcinogenesis, and tumor suppression.

"This study is ground breaking because it shows that olive oil and a Mediterranean diet affect our bodies in a far more significant way than previously believed," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Not only does this research offer more support for encouraging people to change their eating habits, it is an important first step toward identi
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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

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