Navigation Links
Viral life cycle of malignant catarrhal fever explained
Date:4/5/2010

This release is available in Spanish.

The mysterious life cycle of a sheep virus that causes malignant catarrhal fever (MCF) has been discovered by Agricultural Research Service (ARS) scientists and their university collaboratorsthe first step in developing a vaccine against the disease.

Microbiologist Hong Li and veterinary medical officer Naomi Taus at the ARS Animal Diseases Research Unit in Pullman, Wash., collaborated on the research with Lindsay Oaks at Washington State University and Donal O'Toole at the University of Wyoming.

MCF, a viral infection that is a leading cause of disease in American bison, is usually transmitted from sheep to bison and cattle. Vaccine development has been stymied because the virus won't grow in cell culture.

The ARS scientists and their university colleagues have shown that the virus undergoes several changes inside the animal's body, targeting specific cell types at different stages of its own life cycle. This process is called "cell tropism switching."

The viral replication in sheep can be divided into three stages: entry, maintenance, and shedding. The virus enters the sheep through its nasal passages and reaches the lungs, where it replicates. Replication in the sheep lung is required for the virus to change its cell tropism for the next stage: the infection of lymphocytes, a type of immune cell.

During this maintenance stage, the virus stays in the lymphocytes that circulate through the whole body, with little replication. This type of infection is referred to as a "latent infection." During the shedding stage, the virus reactivates from the infected lymphocytes and targets specific cells in the nasal area to complete its replication. The virus is then shed through the sheep's nasal secretions.

Now that they understand these viral changes, scientists can begin to find the right cell types to grow the virus in cell culture, according to Li.


'/>"/>

Contact: Sharon Durham
Sharon.Durham@ars.usda.gov
301-504-1611
United States Department of Agriculture-Research, Education, and Economics
Source:Eurekalert

Related biology news :

1. Clearance of hepatitis C viral infection after liver transplantation
2. Feline virus, antiviral drug studied to understand drug resistance
3. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
4. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
5. Scientists discover DNA knot keeps viral genes tightly corked inside shell
6. Control switches found for immune cells that fight cancer, viral infection
7. A viral cloaking device
8. Viral recombination another way HIV fools the immune system
9. Viral magic bullet targets cancer cells with help of new compound
10. Yamanaka eliminates viral vector in stem cell reprogramming
11. NIAID funds studies of how SARS and bird flu evade antiviral responses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2016)... , December 22, 2016 SuperCom (NASDAQ: ... secure solutions for the e-Government, Public Safety, HealthCare, and Finance sectors ... SuperCom, has been selected to implement and deploy a community-based supportive ... Northern California , further expanding its presence in the ... This new ...
(Date:12/16/2016)... , Dec. 16, 2016   IdentyTechSolutions ... Identity management products and solutions and a cutting-edge ... today that it is offering seamless, integrated solutions ... security entrance products. The solutions provide IdentyTech,s customers ... secure their facilities from crime and theft. ...
(Date:12/15/2016)... , Dec. 15, 2016   WaferGen Bio-systems, Inc. ... genomics technology company, announced today that on December 13, ... Department of The Nasdaq Stock Market LLC which acknowledged ... price of WaferGen,s common stock had been at $1.00 ... has regained compliance with Listing Rule 5550(a)(2) of the ...
Breaking Biology News(10 mins):
(Date:1/14/2017)... Va. , Jan. 13, 2017  The Alliance ... statement in response to FDA final guidance ... for its continued leadership in emphasizing the importance of ... are keenly aware of the benefits biosimilars will bring ...   Yet the portion of the Guidance ...
(Date:1/13/2017)... Island, NY (PRWEB) , ... January 13, 2017 ... ... teamed up with several companies to offer its customers three new solutions for ... probe would come in handy if a customer has an oddly-shaped sample that ...
(Date:1/12/2017)... ... 12, 2017 , ... After her brain cancer became resistant ... only a few months to live. Now a paper publishing January 17 in ... and increased both the quantity and quality of her life: Adding the anti-malaria ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... has enhanced the platform to accommodate increasingly complex and sophisticated deployments, resulting ... and more. In addition to these improvements, the latest release brings enhanced ...
Breaking Biology Technology: