Navigation Links
Viral life cycle of malignant catarrhal fever explained
Date:4/5/2010

This release is available in Spanish.

The mysterious life cycle of a sheep virus that causes malignant catarrhal fever (MCF) has been discovered by Agricultural Research Service (ARS) scientists and their university collaboratorsthe first step in developing a vaccine against the disease.

Microbiologist Hong Li and veterinary medical officer Naomi Taus at the ARS Animal Diseases Research Unit in Pullman, Wash., collaborated on the research with Lindsay Oaks at Washington State University and Donal O'Toole at the University of Wyoming.

MCF, a viral infection that is a leading cause of disease in American bison, is usually transmitted from sheep to bison and cattle. Vaccine development has been stymied because the virus won't grow in cell culture.

The ARS scientists and their university colleagues have shown that the virus undergoes several changes inside the animal's body, targeting specific cell types at different stages of its own life cycle. This process is called "cell tropism switching."

The viral replication in sheep can be divided into three stages: entry, maintenance, and shedding. The virus enters the sheep through its nasal passages and reaches the lungs, where it replicates. Replication in the sheep lung is required for the virus to change its cell tropism for the next stage: the infection of lymphocytes, a type of immune cell.

During this maintenance stage, the virus stays in the lymphocytes that circulate through the whole body, with little replication. This type of infection is referred to as a "latent infection." During the shedding stage, the virus reactivates from the infected lymphocytes and targets specific cells in the nasal area to complete its replication. The virus is then shed through the sheep's nasal secretions.

Now that they understand these viral changes, scientists can begin to find the right cell types to grow the virus in cell culture, according to Li.


'/>"/>

Contact: Sharon Durham
Sharon.Durham@ars.usda.gov
301-504-1611
United States Department of Agriculture-Research, Education, and Economics
Source:Eurekalert

Related biology news :

1. Clearance of hepatitis C viral infection after liver transplantation
2. Feline virus, antiviral drug studied to understand drug resistance
3. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
4. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
5. Scientists discover DNA knot keeps viral genes tightly corked inside shell
6. Control switches found for immune cells that fight cancer, viral infection
7. A viral cloaking device
8. Viral recombination another way HIV fools the immune system
9. Viral magic bullet targets cancer cells with help of new compound
10. Yamanaka eliminates viral vector in stem cell reprogramming
11. NIAID funds studies of how SARS and bird flu evade antiviral responses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
(Date:4/14/2016)... AVIV, Israel , April 14, 2016 ... Behavioral Authentication and Malware Detection, today announced the appointment ... already assumed the new role. Goldwerger,s leadership ... BioCatch, on the heels of the deployment of its ... addition, BioCatch,s behavioral biometric technology, which discerns unique cognitive ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, ... microbial test has received AOAC Research Institute approval 061601. , “This is another ... year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
(Date:6/23/2016)... India , June 23, 2016 ... media market research report to its pharmaceuticals section ... profiles, product details and much more. ... spread across 151 pages, profiling 15 companies and ... available at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . ...
Breaking Biology Technology: