Navigation Links
Viral evasion gene reveals new targets for eliminating chronic infections
Date:1/5/2011

Walter and Eliza Hall Institute researchers in Melbourne, Australia, have discovered how a key viral gene helps viruses evade early detection by the immune system. Their finding is providing new insights into how viruses are able to establish chronic infections, leading scientists to reevaluate their approaches to viral vaccine development.

Researchers from the institute's Immunology division together with collaborators at the University of Cambridge (UK) have been studying how the immune system responds to viruses that cause persistent or chronic infections and why the immune system is unable to eliminate these infections.

Dr Gabrielle Belz, Dr Adele Mount and colleagues are particularly interested in immune system cells called dendritic cells and their interaction with viruses that cause chronic infections.

"Chronic infections are one of the greatest health challenges for the Western world, but currently we have very few ways of dealing with them," Dr Belz said. "They require ongoing medical care and support due to an inability to treat infection effectively.

"We are trying to understand how chronic infections sneak past the usually highly effective immune armoury and covertly establish disease. If we can stop these infections establishing then we can eliminate, or substantially reduce, that societal burden."

Dendritic cells, which are studied by Dr Belz, Dr Mount and colleagues, act as 'sentinels' of the immune system; they are critical for the early detection of invading bacteria and viruses and are one of the first cells to trigger the immune response. "Dendritic cells are called 'antigen presenting cells'; they digest infectious agents into small fragments and shuttle these fragments to the outside of the cell where they are displayed to virus-specific killer T cells, helping to launch a full-blown immune response," Dr Belz said.

The team has been investigating a virus called gamma herpesvirus-
'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
2. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
3. Intriguing viral link to intestinal cancer in mice
4. Texas Tech researcher: Bee colony collapse associated with viral, fungal infection
5. RD114 envelope proteins provide an effective and versatile approach to pseudotype lentiviral vectors
6. Exciting new avenues of research and policy drive expansion of HIV treatment access, use of antiretrovirals to prevent infections and pursuit of a cure
7. Scientists discover ancient viral invasion that shaped human genome
8. Viral life cycle of malignant catarrhal fever explained
9. Development of new anti-cancer gene therapy approach using lentiviral vectors
10. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
11. Statement of ESHRE on the European Commission proposal of viral screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Viral evasion gene reveals new targets for eliminating chronic infections
(Date:10/1/2014)... 2014 Novel detection technology ... field  The life science field has ... the years. Some are shooting stars and others ... novel detection technology that has raised much enthusiasm ... technology is becoming commercially available. With their unique ...
(Date:9/30/2014)... we think of nature as something that we enjoy when ... "preserve?" Or do we think of ourselves as a part ... but what about a house? , The answers to ... in our actions, our speech and in cultural artifacts. , ... of Washington, the American Indian Center of Chicago and the ...
(Date:9/30/2014)... and Howard Hughes Medical Institute investigator, and Margarita ... in the 2014 round of grants from the ... (Brain Research through Advancing Innovative Neurotechnologies) Initiative for ... 30, provides more than $3 million in funding ... The BRAIN Initiative, launched last year, is a ...
Breaking Biology News(10 mins):First-of-a-kind Solution for Utilizing Photon Upconversion 2The cultural side of science communication 2Salk scientists receive $3 million for BRAIN Initiative grant 2
... quest for healthier, younger looking skin, scientists from ... have made an important discovery toward manipulating skin ... range from helping doctors develop more natural looking ... new products for achieving the perfect sunless tan. ...
... mediated phosphorylation is generally recognised as the major ... cells including proliferation, gene expression, motility, vesicular transport ... plays a major role in many diseases such ... elucidation of many kinase cascades has proved pivotal ...
... have struggled to chase down speeding vehicles as the movie ... fearsome carnivore was certainly no slouch, research out today suggests. ... to calculate the running speeds of five meat-eating dinosaurs that ... Tyrannosaurus. The study believed to be the most ...
Cached Biology News:Scientists discover important beauty secret for balanced skin color and tone 2All eukaryotic kinases share 1 common set of substrates 2T. rex quicker than Becks, say scientists 2
(Date:9/30/2014)... Follow us on LinkedIn ... of cholesterol carrier or lipoprotein in the blood. Such ... levels in the body, especially along the walls of ... and other cardiovascular disorders. Cardiovascular Diseases (CVD) is the ... levels on a regular basis, to assess an individual’s ...
(Date:9/30/2014)... ORLANDO, Fla. , Sept. 30, 2014 ... is pleased to announce that it has entered into ... Biotechnologies, Inc. (Tianhe) which has licensed a series of patented ... stem cells for possible clinical applications.  Tianhe is performing ... and Spain using Tianhe,s ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 ... solutions for drug discovery and related life ... consortium has chosen Genedata Selector as its ... (NGS) data. FUNGITECT is a European consortium ... fungal diseases via individualized anti-fungal drug therapies. ...
(Date:9/30/2014)... CORALVILLE, Iowa , Sept. 30, 2014 /PRNewswire/ ... in the discovery and development of proprietary new ... United States Patent and Trademark Office (USPTO) issued ... patent application entitled, "Benzoic Acid, Benzoic Acid Derivatives ... Methods of Making and Use Thereof." ...
Breaking Biology Technology:Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2
... President of the Drug Information Association (DIA)-- , ... a privately held biopharmaceutical company, today announced the appointment ... vice president and chief medical officer. , , ... experience to Horizon and will lead the regulatory and ...
... REYKJAVIK, Iceland, June 29 ... ) and academic colleagues from,Iceland, the Netherlands and Denmark ... kidney stones and decreased bone mineral,density (BMD). About 60% ... in the human genome (SNP) on chromosome 21, putting,them ...
... ON, June 29 /PRNewswire-FirstCall/ - YM BioSciences Inc. ... life sciences product development company that identifies and ... at various stages of development, today reported that ... have resolved the issues between the companies in ...
Cached Biology Technology:Horizon Therapeutics Names Dr. Jeffrey W. Sherman Executive Vice President and Chief Medical Officer 2deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis 2deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis 3deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis 4YM BIOSCIENCES' SUBSIDIARY RESOLVES PROPOSED ARBITRATION WITH ONCOSCIENCE AG 2YM BIOSCIENCES' SUBSIDIARY RESOLVES PROPOSED ARBITRATION WITH ONCOSCIENCE AG 3YM BIOSCIENCES' SUBSIDIARY RESOLVES PROPOSED ARBITRATION WITH ONCOSCIENCE AG 4
... On-Demand Cytometry The Guava ... blue laser based multiparameter cytometer with built-in ... you can screen plates of cells and ... of manipulating multiple tubes or having the ...
A flexible 24-48 hour DNA sequencing service. Samples may be shipped in standard 1.5mL tubes. Oligo synthesis and DNA preparation available. Read lengths up to 850 Phred 20 bases. Universal primers p...
... Agencourt offers single pass sequencing of ... is fueled by our high performance ... million Phred20 bases per day. The ... pass sequencing customers are rapid turnaround, ...
... Facility , Galaxy LIMS, Sophisticated Bioinformatics , ... scientists ,We offer individual sample sequencing of ... for single or double strand publication quality. ... DNA of interest is 1.3 to 7 ...
Biology Products: