Navigation Links
Viral evasion gene reveals new targets for eliminating chronic infections
Date:1/5/2011

Walter and Eliza Hall Institute researchers in Melbourne, Australia, have discovered how a key viral gene helps viruses evade early detection by the immune system. Their finding is providing new insights into how viruses are able to establish chronic infections, leading scientists to reevaluate their approaches to viral vaccine development.

Researchers from the institute's Immunology division together with collaborators at the University of Cambridge (UK) have been studying how the immune system responds to viruses that cause persistent or chronic infections and why the immune system is unable to eliminate these infections.

Dr Gabrielle Belz, Dr Adele Mount and colleagues are particularly interested in immune system cells called dendritic cells and their interaction with viruses that cause chronic infections.

"Chronic infections are one of the greatest health challenges for the Western world, but currently we have very few ways of dealing with them," Dr Belz said. "They require ongoing medical care and support due to an inability to treat infection effectively.

"We are trying to understand how chronic infections sneak past the usually highly effective immune armoury and covertly establish disease. If we can stop these infections establishing then we can eliminate, or substantially reduce, that societal burden."

Dendritic cells, which are studied by Dr Belz, Dr Mount and colleagues, act as 'sentinels' of the immune system; they are critical for the early detection of invading bacteria and viruses and are one of the first cells to trigger the immune response. "Dendritic cells are called 'antigen presenting cells'; they digest infectious agents into small fragments and shuttle these fragments to the outside of the cell where they are displayed to virus-specific killer T cells, helping to launch a full-blown immune response," Dr Belz said.

The team has been investigating a virus called gamma herpesvirus-68, which establishes chronic infections in mice and provides a model of the workings of the human gamma herpesvirus Epstein-Barr Virus, commonly known to cause infectious mononucleosis, or 'kissing disease'. Their results, which have been published in the Journal of Immunology show that a viral gene called K3 rapidly disables the antigen-processing machinery normally used by dendritic cells to alert the immune system to infections.

"This gene quickly helps the virus to hide from the immune system by subverting normal antigen presentation to T cells, which have the critical task of destroying virally-infected cells," Dr Belz said. "The virus carries out a top-secret operation. It shuts down the normal mechanisms that allow the immune system to recognise an infection and then boards the antigen-presenting cells which ferry the virus through the blood and tissues, allowing it to spread throughout the body and establish system infection."

Dr Belz said the study could change conventional views on the best way to generate an immune response to combat chronic infections.

"Our research shows that viral evasion of the immune system in chronic infections happens incredibly early," Dr Belz said. "Dendritic cells are compromised long before they have the chance to interact with T cells for the next phase of the immune response, so the T cells are never really activated properly. If we want to make an effective vaccine, we need to look at these early escape points used by the virus as the first target for trying to generate a more efficient immune response that will contain the virus and prevent it establishing a systemic infection."


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
2. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
3. Intriguing viral link to intestinal cancer in mice
4. Texas Tech researcher: Bee colony collapse associated with viral, fungal infection
5. RD114 envelope proteins provide an effective and versatile approach to pseudotype lentiviral vectors
6. Exciting new avenues of research and policy drive expansion of HIV treatment access, use of antiretrovirals to prevent infections and pursuit of a cure
7. Scientists discover ancient viral invasion that shaped human genome
8. Viral life cycle of malignant catarrhal fever explained
9. Development of new anti-cancer gene therapy approach using lentiviral vectors
10. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
11. Statement of ESHRE on the European Commission proposal of viral screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Viral evasion gene reveals new targets for eliminating chronic infections
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/23/2016)... 23, 2016 ... Gesichts- und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler ... mit SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie ... die Möglichkeit angeboten, im Rahmen mobiler Apps ...
(Date:3/17/2016)... , March 17, 2016 ABI Research, ... forecasts the global biometrics market will reach more ... 118% increase from 2015. Consumer electronics, particularly smartphones, ... fingerprint sensors anticipated to reach two billion shipments ... Dimitrios Pavlakis , Research Analyst at ABI ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... , ... Weeks after hosting a carpal tunnel syndrome workshop with Dr. Oz ... founder of the Fitzmaurice Hand Institute, has announced the addition of MRI diagnostic imaging ... and only 1 of about 3 currently available in the United States. Developed specifically ...
(Date:5/27/2016)... 27, 2016 At present, the Biotech ... this space know that volatility is what makes this industry ... ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), CTI ... LPTN ), and Heat Biologics Inc. (NASDAQ: ... the technical alerts for these stocks at: ...
(Date:5/26/2016)... -- Despite the volatility that continues to envelop ... pre-market research on ActiveWallSt.com directs the investor community,s focus on ... RDUS ), Cerus Corp. (NASDAQ: CERS ), Arrowhead ... Therapeutics Inc. (NASDAQ: FPRX ). Register with us ... http://www.activewallst.com/ On Wednesday, shares in ...
(Date:5/25/2016)... ... ... Lajollacooks4u has become a rising hotspot for specialized team building events in ... Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm and Elsevier, have traveled from ... Each event kicks off with an olive oil and salt-tasting competition. From there, ...
Breaking Biology Technology: