Navigation Links
'Vicious circle' offers new acute leukemia treatment target
Date:4/13/2010

s senior co-leader Dr. Ramiro Garzon, assistant professor of internal medicine and an AML specialist at the OSUCCC-James.

"These findings provide a strong rationale for the use and development of drugs that target the components of this network rather than focusing on the activity of KIT alone."

Marcucci, Garzon, first author Shujun Liu, assistant professor of internal medicine, and their colleagues began this study by showing that patients with mutations in the KIT gene in their leukemic cells had the highest levels of the KIT protein in those cells, and that these patients also had the poorest survival.

"This told us that the amount of the protein in cancer cells is important to the disease process," Liu says.

Using laboratory-grown AML cells, the researchers identified the series of molecules that control the amount of KIT protein, showing for the first time that a microRNA called miR-29b, along with several well-known cancer-related genes, regulate KIT production.

Normally, these elements work in a balanced fashion to produce the correct amount of KIT protein for healthy cell survival and proliferation. That normal balance is derailed when gene mutations or other genetic damage occurs in the network and promotes the overproduction of the KIT protein.

"It becomes a vicious circle because no matter where genetic damage occurs, the result is the same overactivation of the circle, overexpression of the KIT protein, and proliferation of leukemic cells," Liu says.

Using a mouse model, the researchers showed that raising the amount of mutated KIT protein causes leukemia, and drugs that target the network lower the amount of that protein and drive the leukemia into remission. These drugs included proteasome inhibitors, histone deacetylase inhibitors, along with inhibitors of molecules called NFĸB and Sp1.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tall tale of giant stingray circles the globe
2. Nations largest organization of ecologists offers expert database
3. Fertility industry offers big money to recruit desirable egg donors at top universities
4. DNA nanotechnology breakthrough offers promising applications in medicine
5. New microscopy technique offers close-up, real-time view of cellular phenomena
6. Society of Interventional Radiology Press offers new edition of patient care resource
7. The sea squirt offers hope for Alzheimers sufferers
8. TriCipher myOneLogin SignatureBook Offers Digital Signatures On-Demand
9. Brain study offers insight into causes of autism
10. Synthetic biology offers new opportunities for interdisciplinary collaboration
11. Society of Interventional Radiology hosts oncology therapies Webinar, offers resources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... research at the University of Adelaide has opened the way ... to powdery mildew. , In Australia, annual barley production is ... Powdery mildew is one of the most important diseases of ... have discovered the composition of special growths on the cell ... fungus into the leaf. , The research, by the ARC ...
(Date:7/25/2014)... for Medical Research have identified the functions of ... to triggering the mating process in mice. , They ... detect pheromones that indicate when a female is present. ... the female mouse is ovulating and ready to mate. ... Stowers, researchers believe mice developed this system through evolution ...
(Date:7/24/2014)... many sobering examples of how wildlife loss leads to ... co-authored by Wildlife Conservation Society (WCS) Health & ... Golden, calls for an interdisciplinary approach to tackle global ... supports about 15% of the world,s people and provides ... poor. It should come as no surprise that today,s ...
Breaking Biology News(10 mins):New hope for powdery mildew resistant barley 2It takes two to court 2It takes two to court 3New study draws links between wildlife loss and social conflicts 2
... A Web site is a better source of information ... to a study of low-income mothers reported in the January ... http://www.jneb.org/) . Led by Kami J. Silk, Ph.D., of ... mothers with nutrition information in different formats. One group ...
... stars have understudies. Now, an increasingly popular radioactive ... by researchers at the National Institute of Standards ... medical imaging, speed up clinical trials of many ... medical treatment. The number of medical images ...
... knees on your list of New Year,s resolutions? ... wait longer to pursue knee-replacement surgery than men do. ... stand the pain, these women may also risk putting ... according to Lynn Snyder-Mackler, Distinguished Alumni Professor in UD,s ...
Cached Biology News:For nutrition info, moms like the Web best 2Radioactive 'understudy' may aid medical imaging, drug development 2Listen-up ladies: Don't postpone knee-replacement surgery 2Listen-up ladies: Don't postpone knee-replacement surgery 3
(Date:7/24/2014)... equipment, trained personnel, and detection dogs to safeguard ... A revolutionary new electronic chip with nano-sized chemical ... easier. , The groundbreaking nanotechnology-inspired sensor, devised by ... School of Chemistry and Center for Nanoscience and ... picks up the scent of explosives molecules better ...
(Date:7/24/2014)... 24, 2014 Research and Markets ... Culture Market 2014-2018" report to their offering.  ... culture is the in vitro growth of plant or ... studies, and biopharmaceutical production. Cell culture is a crucial ... instruments and cell culture consumables are necessary for the ...
(Date:7/24/2014)... Three companies from the angelMD network ... C Competition. Out of 700 competition entrants, Chiron Health, ... semi-final round. In this round twenty teams are invited ... with mentoring from thought-leaders and medical entrepreneurs from all ... angelMD commitment to the Livestrong vision around the Big ...
(Date:7/24/2014)... Canada (PRWEB) July 24, 2014 The ... Optimizing Dose Escalation in First in Human Studies” will ... make better go/no-go decisions. , With increasing R&D costs ... pharmaceutical companies need to maximize the knowledge collected in ... decisions and improve success in late stage development. , ...
Breaking Biology Technology:Nano-sized chip 'sniffs out' explosives far better than trained dogs 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2
... backorders and new product pipeline provide positive outlook ... plans to lay off workers at its Chippewa Falls ... company has a recorded a significant increased order backlog ... $51 million and up from $75 million in the ...
... issue, I noted that while wireless communications were about to ... rather uninspired. For all the hype around mobile data services, ... - the fare that was easier and cheaper to receive ... , ,Then I had a pretty busy week, visiting with ...
... song Bits and Pieces is a good metaphor for the apparently ... early stage financing efforts to get life science companies off the ... some of these pieces so the tapestry doesnt fall apart. Last ... on my negligence in mentioning other seed and early stage life ...
Cached Biology Technology:Cray reports $54.5 million loss, plans layoff in Chippewa Falls 2Cray reports $54.5 million loss, plans layoff in Chippewa Falls 3Readers respond - Imagining the possibilities 2Readers respond - Imagining the possibilities 3More Midwest Seed-Stage Life Science VCs 2More Midwest Seed-Stage Life Science VCs 3More Midwest Seed-Stage Life Science VCs 4More Midwest Seed-Stage Life Science VCs 5More Midwest Seed-Stage Life Science VCs 6
... Data System (CDS) now provides integrated ... data processing and reporting for the ... The companys innovative HPLC instrument has ... of Thermo Scientific Hypersil GOLD 1.9 ...
...
...
... Exiqon's miRCURY LNA technology enables sensitive ... Northern blotting. miRCURY LNA Detection probes have ... specific and sensitive detection of miRNAs. Due ... miRCURY LNA probes less than 1/10 the ...
Biology Products: