The $374,000 grant will allow Inzana and his fellow investigators, Drs. Indra Sandal and William Scarratt to study the role of biofilm in the virulence of Histophilus somni (Haemophilus somnus), one of the bacteria responsible for BRDC.
If we can understand the protective or disease-enhancing effect a biofilm provides to H. somni then we can develop more successful and efficacious vaccines for this and other biofilm diseases, said Inzana.
A biofilm is an organized community of bacteria that forms a glue-like substance that adheres to a variety of surfaces.
The plaque on your teeth is a biofilm, as is the slime that often forms on meat that has been left out too long. While some biofilms are harmless, they can also cause a variety of diseases in humans and animals, explains Inzana. Middle-ear infections and cystic fibrosis are both examples of biofilm diseases that can form in humans.
A biofilm can be particularly hard to treat because the bacteria are encased in an organized matrix that forms a protective architecture, resulting in enhanced bacterial resistance to antibiotics.
In bovines, BRDC is a particularly troublesome disease that remains a major economic problem, despite years of extensive research, according to Inzana. BRDC accounts for over 60 percent of all deaths in feedlot cattle, said Inzana, which leads to major financial losses for producers.
Inzana and his fellow researchers believe H. somni naturally occurs in a biofilm state within the bovine host. This may cause H. somni to
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