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Veterinary college researcher studying brain tumors in people and animals
Date:3/31/2008

e dogs suitability as a model for studying pre-clinical human disease, according to Rossmeisl, and ultimately lead to the development of more precisely targeted methods for managing these tumors.

Another portion of the work is focused on the development of powerful new cancer treatments. Through a process known as convection enhanced delivery (CED), the researchers are removing the diseased tissues and testing the application of a proprietary experimental compound. This agent is used to bathe the margins of the area in which the tumor was removed and it has been designed in a way that it will only bind with receptors in tumor cells expressing abnormal proteins.

Their potential value is tremendous to humans and dogs with cancer, said Rossmeisl. These treatments may represent a significant advancement in prolonging survival in dogs and people with these highly aggressive cancers.

The researchers will also be looking at improved processes for performing radiation therapy on brain tumors in dogs.

Currently, the standard of care in veterinary radiotherapy is fractional radiotherapy delivered with a linear accelerator, explained Rossmeisl. This form of radiation therapy is typically delivered with frequent administration of relatively small doses of radiation multiple days per week over several weeks. Though it can be fairly precisely targeted, it can affect tissues unrelated to the tumor.

The grant will enable the researchers to perfect protocols for treating canine patients with stereotactic radiosurgery more commonly known as the gamma knife. The gamma knife uses a specialized head-frame to target an exactingly focused beam of killing radiation with pin-point accuracy on the tumor itself. As opposed to a traditional course of radiotherapy that can take weeks, the gamma knife can accomplish the task in one session lasting a few hours.


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Contact: Jeff Douglas
jdouglas@vt.edu
540-231-7911
Virginia Tech
Source:Eurekalert

Page: 1 2 3

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