Navigation Links
Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
Date:12/25/2007

CHICAGO Among several U.S. racial/ethnic groups examined, Hispanic women were found to have the highest prevalence of the cancer-associated gene mutation BRCA1 at 3.5 percent, with Asian Americans having the lowest prevalence (0.5 percent), according to a study in the December 26 issue of JAMA.

Mutations in the tumor suppressor gene BRCA1 confer high risks of breast and ovarian cancer. Average cumulative risk by age 70 years has been estimated at 65 percent for breast cancer and 39 percent for ovarian cancer, according to background information in the article. Although mutations in BRCA1 are rare, they are more frequently present in individuals with multiple relatives having breast or ovarian cancer, early-onset breast cancer, or of Ashkenazi Jewish ancestry. Information on the prevalence of BRCA1 mutation carriers in racial/ethnic minority populations is limited.

Esther M. John, Ph.D., of the Northern California Cancer Center, Fremont, Calif., and colleagues examined the prevalence of BRCA1 mutations in Hispanic, African American and Asian American female breast cancer patients compared with non-Hispanic white patients with and without Ashkenazi Jewish ancestry. The patients, younger than 65 years at diagnosis, were enrolled at the Northern California site of the Breast Cancer Family Registry (n = 3,181) during the period 1996-2005.

In patients without reported Ashkenazi Jewish ancestry, estimated mutation prevalence was highest in Hispanic patients (3.5 percent), followed by non-Hispanic white patients (2.2 percent), African American patients (1.3 percent), and Asian American patients (0.5 percent). Those with Ashkenazi Jewish ancestry had a prevalence of 8.3 percent. Within each racial/ethnic group, prevalence estimates decreased with age at diagnosis and were higher in patients who reported a family history of breast or ovarian cancer than in those who did not.

The prevalence of BRCA1 mutations was particularly high in African American patients diagnosed before age 35 years (16.7 percent), compared with young Hispanics (8.9 percent), non-white Hispanics without Ashkenazi Jewish ancestry (7.2 percent), and Asian Americans (2.4 percent).

The present study included multiple racial/ethnic groups, therefore allowing direct comparison of carrier prevalence estimates. Since certain mutations may be unique to specific populations, the full spectrum of mutations needs to be determined. Such information may facilitate mutation screening in a clinical setting and is needed to guide resource allocation for genetic testing, genetic counseling, and planning of preventive interventions in all population subgroups, the authors conclude.

(JAMA. 2007;298(24):2869-2876. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


Editorial: Genetic Testing in Diverse Populations - Are Researchers Doing Enough to Get Out the Correct Message?

In an accompanying editorial, Dezheng Huo, M.D., Ph.D., and Olufunmilayo I. Olopade, M.D., of the University of Chicago, comment on the findings regarding genetic testing for BRCA1.

As documented by John et al, more than half of BRCA1 mutation carriers would be detected in female patients with breast cancer whose cancers are likely to be hereditary based on age at diagnosis and family history. The differences in BRCA1 mutation prevalence across populations should be used to more accurately calculate the pretest probability of having a mutation, rather than as evidence against genetic testing in minority populations. While there has been great debate about the role of race/ethnicity in health research, clinicians interested in providing patients with personalized assessment of cancer risk must understand the contributions of BRCA1 and BRCA2 mutations in diverse populations, because potential modifying factors particular to patients race/ethnicity, family history, ancestral country of origin, and environmental factors may work in concert to influence outcomes.

(JAMA. 2007;298(24):2910-2911. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including financial disclosures, funding and support, etc.


'/>"/>

Contact: Rachael Vander Martin
510-608-5160
JAMA and Archives Journals
Source:Eurekalert

Related biology news :

1. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
2. Misconceptions about Alzheimers varies among races, survey suggests
3. Tree of life for flowering plants reveals relationships among major groups
4. UF botanists: Flowering plants evolved very quickly into 5 groups
5. Presence of gene mutation helps guide thyroid cancer treatment
6. Mutation of the COX2 gene can double or treble a womans risk of ovarian cancer
7. New study reveals for first time how BRCA1 mutations cause breast cancer
8. Men unaware of their cancer risk when female relatives test positive for BRCA mutation
9. Study finds Viagra increases release of key reproductive hormone
10. Springer increases publishing activities in South Korea
11. Age increases chance of success as two-timer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... 2016 The report "Biometric Vehicle ... Technology (Iris Recognition System), Vehicle Type (Passenger Car, ... to 2021", published by MarketsandMarkets, the market is ... and is projected to grow to USD 854.8 ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/29/2016)... , Nov. 29, 2016   ... identification and object recognition technologies, today released ... for fingerprint recognition solutions that run on ... fingerprint template using less than 128KB of ... compact devices that have limited on-board resources, ...
(Date:11/22/2016)... , Nov. 22, 2016   MedNet Solutions ... the entire spectrum of clinical research, is pleased to ... Medical LiveWire Healthcare and Life Sciences Awards as ... caps off an unprecedented year of recognition and growth ... for over 15 years. iMedNet ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... Discovering new clues to natural treatments that could ... happening in our brains. And searching for keys to our immune systems by studying ... with the 2017 Edith and Peter O’Donnell Awards by The Academy ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... announced today that the company has engaged in a collaborative research partnership with ... with the CSU Office of the Vice President for Research. This agreement is ...
(Date:12/6/2016)... 6, 2016 According to a new market ... (Polymer, Glass, Silicon), Application (Genomics, Proteomics, Capillary Electrophoresis, POC, Clinical, Environmental, ... global market is projected to reach USD 8.78 Billion by 2021 ... during the forecast period (2016 to 2021). ... ...
(Date:12/6/2016)... 2016 Zimmer Biomet Holdings, Inc. (NYSE ... pricing terms of its previously-announced cash tender offers ... price (excluding accrued and unpaid interest to, but ... fees and expenses related to the Offers) (the ... in the table below (collectively, the "Notes"). The ...
Breaking Biology Technology: