Navigation Links
Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
Date:12/25/2007

CHICAGO Among several U.S. racial/ethnic groups examined, Hispanic women were found to have the highest prevalence of the cancer-associated gene mutation BRCA1 at 3.5 percent, with Asian Americans having the lowest prevalence (0.5 percent), according to a study in the December 26 issue of JAMA.

Mutations in the tumor suppressor gene BRCA1 confer high risks of breast and ovarian cancer. Average cumulative risk by age 70 years has been estimated at 65 percent for breast cancer and 39 percent for ovarian cancer, according to background information in the article. Although mutations in BRCA1 are rare, they are more frequently present in individuals with multiple relatives having breast or ovarian cancer, early-onset breast cancer, or of Ashkenazi Jewish ancestry. Information on the prevalence of BRCA1 mutation carriers in racial/ethnic minority populations is limited.

Esther M. John, Ph.D., of the Northern California Cancer Center, Fremont, Calif., and colleagues examined the prevalence of BRCA1 mutations in Hispanic, African American and Asian American female breast cancer patients compared with non-Hispanic white patients with and without Ashkenazi Jewish ancestry. The patients, younger than 65 years at diagnosis, were enrolled at the Northern California site of the Breast Cancer Family Registry (n = 3,181) during the period 1996-2005.

In patients without reported Ashkenazi Jewish ancestry, estimated mutation prevalence was highest in Hispanic patients (3.5 percent), followed by non-Hispanic white patients (2.2 percent), African American patients (1.3 percent), and Asian American patients (0.5 percent). Those with Ashkenazi Jewish ancestry had a prevalence of 8.3 percent. Within each racial/ethnic group, prevalence estimates decreased with age at diagnosis and were higher in patients who reported a family history of breast or ovarian cancer than in those who did not.

The prevalence of BRCA1 mutations was particularly high i
'/>"/>

Contact: Rachael Vander Martin
510-608-5160
JAMA and Archives Journals
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
2. Misconceptions about Alzheimers varies among races, survey suggests
3. Tree of life for flowering plants reveals relationships among major groups
4. UF botanists: Flowering plants evolved very quickly into 5 groups
5. Presence of gene mutation helps guide thyroid cancer treatment
6. Mutation of the COX2 gene can double or treble a womans risk of ovarian cancer
7. New study reveals for first time how BRCA1 mutations cause breast cancer
8. Men unaware of their cancer risk when female relatives test positive for BRCA mutation
9. Study finds Viagra increases release of key reproductive hormone
10. Springer increases publishing activities in South Korea
11. Age increases chance of success as two-timer

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...st as vital to your health as what you eat, found ...tudies. Their experiments in mice revealed that th... the liverthe body,s metabolic clearinghouseis mos...s circadian clock as conventional wisdom had it. ...large number of genes completely independent of th...
(Date:11/24/2009)...oday named 12 new grant recipients for 2009. The a... work across a broad spectrum of lupus research. A...d potential to drive scientific discovery to ultim... of systemic lupus. , The 2009 grants go to both...nation and include interdisciplinary and highly pr...
(Date:11/24/2009)...in that may help gut bacteria bind to the gastroin...otic producers to identify strains that are likely...eed to interact with cells lining the gut to have ...s in the gut they are more likely to stick around ...alie Juge from the Institute of Food Research. IF...
Breaking Biology News(10 mins):Feeding the clock 2Feeding the clock 3Lupus Research Institute announces 2009 novel research grants 2Lupus Research Institute announces 2009 novel research grants 3A sticky solution for identifying effective probiotics 2One Shot May Someday Replace Six for Rabies 58126 1One Shot May Someday Replace Six for Rabies 58126 2University of Hawaii Maui Community College Selects American TeleCare for Allied Health Department 26apos 3Bs Nursing Telehealth Project 58122 1University of Hawaii Maui Community College Selects American TeleCare for Allied Health Department 26apos 3Bs Nursing Telehealth Project 58122 2University of Hawaii Maui Community College Selects American TeleCare for Allied Health Department 26apos 3Bs Nursing Telehealth Project 58122 3Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression Free Survival in Patients With Advanced Breast Cancer in P 58118 1Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression Free Survival in Patients With Advanced Breast Cancer in P 58118 2Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression Free Survival in Patients With Advanced Breast Cancer in P 58118 3Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression Free Survival in Patients With Advanced Breast Cancer in P 58118 4Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression Free Survival in Patients With Advanced Breast Cancer in P 58118 5Nexavar in Combination With Chemotherapy Demonstrates 74 Percent Improvement in Progression Free Survival in Patients With Advanced Breast Cancer in P 58118 6
...available in French . , A novel x-ray technique... time scale never reached before has been develope...Scherrer Institute (PSI) in Switzerland. Results o...d of EPFL,s laboratory of Ultrafast Spectroscopy i... online December 11 in the journal Science . , T...
...a turtle,s first swim is the most critical of its ...ators to make it to the sea, the tiny voyager must...its bid for freedom. For youngsters hatching on th...gh: as many as 30% perish as they head for safe de...rough the waves cost the intrepid hatchlings? Curi...
...uma National Park, the last stronghold for the sav...ow hover at about 1,000 animals, down from an esti...ic weapons have decimated elephant populations pa...f the park., Civil unrest in has made conservatio...rds have been shot and killed in recent years. Ho...
Other Biology News:Molecules in the spotlight 2Cost of hatchling turtles' dash for freedom 2Missing: 2,000 elephants 2
(Date:11/24/2009)...ire-FirstCall/--CellTherapeutics,Inc.(CTI)(Nasdaqa...erJaffrayHealthCareConference.Theconferencewillbeh... CTIwillpresentonTuesday,December1at11:00a.m.Easte...presentationwillbeavailableat www.celltherapeutics... , ,PiperJaffrayHealthCareConference,NewYorkPalac...
(Date:11/23/2009)...nk of it as origami very high-tech origami. , Re...oped a technique for fabricating three-dimensional...films by coupling photolithography and a self-fold...he films, only a few microns thick, offer mechanic...ieces of the same material. , "This is a complete...
(Date:11/23/2009)...imensional carbon layer in which the carbon atoms ...honeycomb. Carbon nanotubes are rolled-up sheets o...m graphite. Graphene boasts some very special char...cellent thermal conductor, and reconciles such con...n addition, graphene is impermeable to gases, whic...
(Date:11/23/2009)...PRNewswire-FirstCall/-YMBioSciencesInc.(NYSEAmex: ...ythatidentifiesandadvancesadiverseportfolioofpromi...ment,todayreportedthatCytopia(ASX:CYT)hascommenced...t,orally-administeredJAK1/JAK2inhibitor.Thetrialis...roposaltomergeCytopiaintoYMhasbeenpreviouslyannoun...
Breaking Biology Technology:Water droplets direct self-assembly process in thin-film materials 2Polymer with honeycomb structure 2YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 2YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 3YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 4
... Amnis Corporation announced today the,release of ...ding the,Commercial release of a multilaser capabi...dramatically extending the depth of field well bey...ser upgrade provides the customer with the flexibi...05nm (violet) laser and a 658nm,(red) laser. These...
...., Aug. 23 Nektar,Therapeutics (Nasdaq: NKTR ) t...Senior Vice President and CFO. Harkness reports to...l serve as an integral member of the company,s,new...of healthcare and finance, Tim is a,critical addit... "He brings,significant experience in both financi...
...ia, Aug. 23 , Highlights -- Revenue increased 28...illion -- Excluding one-off items EBITDA increase...6 million -- Excluding one-off items NPAT increas....5 million from A$2.0 million -- Reported NPAT gr...r comparable period including one-off items -...
Other Biology Technology:Amnis Announces the Release of Multiple Upgrades to the ImageStream(R) System 2Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer 2Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer 3Ellex FY2007 Year End Results 2Ellex FY2007 Year End Results 3
...ulti-casting chamber is used for handcasting and v...ndcast (8.3 x 7.3 cm) or precast (8.6 x 6.8 cm) ge...udes an electrophoresis tank with built-in cooling...rculator (not included), lid with power cables, 6 ...
Protease Inhibitor Cocktail Set I from Calbiochem
...gnificantly increase the shelf life of diluted per...at room temperature storage conditions in addition...0.2 micron filtration, and contains no mercury or ... levels of activity for both the enzyme and the an...
NucleoSpin Extract II from MACHEREY-NAGEL
Biology Products: