Navigation Links
Variations on the genetic theme
Date:4/8/2010

Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties.

By integrating gene expression data from an unprecedented variety of human tissue samples, Alvis Brazma and his team at the European Bioinformatics Institute, an outstation of the European Molecular Biology Laboratory (EMBL), and their collaborators have for the first time produced a global map of gene expression. The full analysis behind this unique view of the genetic activities determining our appearance, function and behaviour is published today in Nature Biotechnology.

The analysis used data collected from 163 laboratories worldwide involving 5,372 human samples from various tissues, cell types and diseases. Most transcriptomics experiments compare gene expression in only a few cell types or conditions and although technically challenging, integrating this data on a large-scale has created a new way for scientists to explore gene expression. The analysis is visualised as a map subdividing the human gene expression space into six distinct major groups or 'continents'.

The continents emerged by grouping samples with similar gene expression signatures. This established the identity of the six groups: brain; muscle; hematopoietic (blood related); healthy and tumour solid tissues; cell lines derived from solid tissues; and partially differentiated cells. By visualising these subsets in 3D, comparisons can be made on the degree of similarity in the gene expression profiles on each grouping. For example, analysis of the continents showed that cell lines are usually more similar to each other than to their tissue of origin.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1

Related biology news :

1. Study finds variations in 1 gene may be associated with endurance running
2. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
3. Scientists uncover new genetic variations linked to psoriasis
4. U of MN study shows link between gene variations and cancer survival
5. Study helps pinpoint genetic variations in European Americans
6. Statistical tool could explain gene study variations
7. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
8. DNA variations signal lupus risk
9. Physician-scientists seek solutions to reproductive problems related to chromosomal variations
10. Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants
11. New genetic risk factors for aneurysms identified by Yale-led team
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Variations on the genetic theme
(Date:9/30/2014)... England Journal of Medicine reports positive results of ... against the subset of lung cancer marked by rearrangement ... 50 patients with advanced non-small cell lung cancer testing ... 72 percent, with 3 complete responses and 33 partial ... for the disease to resume its growth after being ...
(Date:9/30/2014)... German . ... foods in the world. Because they grow underground, people use ... smell of truffles is not only of interest to gourmets. ... of the Goethe University Frankfurt have discovered that the smell ... are trapped inside truffle fruiting bodies. , White truffles from ...
(Date:9/30/2014)... it comes to using marijuana, new research, involving mice ... Journal of Leukocyte Biology , suggests ... that you should. That,s because a team of Italian ... do serious long-term damage to the immune system. This ... diseases, such as multiple sclerosis, inflammatory bowel disease and ...
Breaking Biology News(10 mins):NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2On the trail of the truffle flavor 2Adolescent exposure to thc may cause immune systems to go up in smoke 2
... in German . , Jena/Leipzig. For ... extended cultivation of energy crops. Scientists have now developed ... comparing the effectiveness of strategies for the reduction of ... leads to problems to biological diversity in agrarian regions. ...
... 2012  The Intellectual Property & Science division of ... information for businesses and professionals, today announced the ... the life sciences market, a new initiative aimed ... information through application-specific solutions developed with third-party partners. ...
... With more than 1.7 million people sustaining a traumatic ... to limit inflammation and subsequent damage is critical. Approximately ... leaving 85,000 with long-term disabilities and taking the lives ... live with disabilities caused by traumatic brain injuries, often ...
Cached Biology News:How the ecological risks of extended bioenergy production can be reduced 2How the ecological risks of extended bioenergy production can be reduced 3Thomson Reuters Launches Life Sciences Partner Ecosystem to Drive Collaborative R&D Drug Processes 2Estrogen hormone reveals protective ability after traumatic brain injury 2
(Date:9/30/2014)... bio-mimicking analog of one of nature,s most efficient ... team led by Alejandro Briseno of the University ... in developing long-sought polymer architecture to boost power-conversion ... electronic devices. , Briseno, with colleagues and ... Stanford University and Dresden University of Technology, Germany, ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released ... highly precise tool for measuring displacement in rubber ... 1000-mm maximum movement distance, the DSES-1000 can measure ... length of 10 mm. In addition, it achieves ... stroke and within +/- 100 µm below 50-mm ...
(Date:9/30/2014)... 30, 2014 Proove Biosciences , ... excited to announce a new genetic test built upon ... Pain Perception Test will provide physicians with an ... pain tolerance levels are stratified between individuals. With this ... a person has a genetic predisposition that will affect ...
(Date:9/30/2014)... Sept. 30, 2014 CORD:USE Cord Blood Bank ... that it has entered into an Equity and Exclusive ... has licensed a series of patented technologies for the isolation ... clinical applications.  Tianhe is performing Phase I/II clinical trials ... Spain using Tianhe,s Stem Cell Educator Therapy ...
Breaking Biology Technology:Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... from North Carolina State University shows that size plays ... hollow nanoparticles. The researchers focused on nickel nanoparticles, which ... applications in fields as diverse as energy production and ... potential for nanofabrication the creation of materials that ...
... push the boundaries of nanoscience, the Kavli Institute at Cornell ... new ideas, but a proving ground to aggressively push the ... named Paul McEuen, the Goldwin Smith Professor of Physics, as ... engineering physics, will serve as co-director. The institute ...
... Choi of the Department of Mechanical Engineering at Stevens ... the 2010 Young Investigator Program (YIP) award by the ... scientists and engineers who show exceptional promise for creative ... young outstanding scientists and engineers," said ONR,s Director of ...
Cached Biology Technology:Study shows that size affects structure of hollow nanoparticles 2Under new leadership, Kavli Institute at Cornell evolves from a think tank to a proving ground 2Dr. Chang-Hwan Choi honored with prestigious Young Investigator Award 2Dr. Chang-Hwan Choi honored with prestigious Young Investigator Award 3