Navigation Links
Variant of vitamin D receptor gene linked to melanoma risk
Date:9/21/2008

A new analysis indicates an association between a gene involved in vitamin D metabolism and skin cancer. Published in the November 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study suggests that individuals with certain variants in a vitamin D-related gene, called BsmI, may be at an increased risk of developing melanoma.

Research has shown that vitamin D in the body has significant protective effects against the development of cancer because it regulates cell growth, cell differentiation and cell death. This is supported by evidence that sun exposure, which helps in the production of vitamin D, can have anticancer effects.

Vitamin D exerts its effects by binding to a receptor located within cells. Because there are genetic differences in this vitamin D receptor among individuals, investigators suspect that different people have different levels of vitamin D activity within their bodies. Therefore, some individuals may naturally be able to achieve more vitamin D-related protection against cancer than others. However, study results on this topic have been conflicting, and no review of the available data has been performed to date.

To address this issue, Dr. Simone Mocellin and Dr. Donato Nitti of the University of Padova in Italy examined the existing research investigating the association between common variants in the vitamin D receptor and the risk of melanoma. The analysis revealed a significant association between melanoma risk and the BsmI gene.

The researchers note that additional research is needed to validate this link, and called for well-designed, population-based, large, multi-institutional studies to test whether any vitamin D receptor variant is independently associated with melanoma risk.

"These findings prompt further investigation on this subject and indirectly support the hypothesis that sun exposure might have an anti-melanoma effect through activation of the vitamin D system," the authors wrote.


'/>"/>

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Genetic variant linked to odor perception
3. New genetic variant associated with prostate cancer in African-Americans
4. Breastfeeding boost IQ in infants with helpful genetic variant
5. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
6. Scientists associate 6 new genetic variants with heart disease risk factor
7. New genetic variants associated with lipid levels, risk for coronary artery disease
8. Gene variant increases breast cancer risk
9. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
10. New vaccine may give long-term defense against deadly bird flu and its variant forms
11. Genetic variant mimics effect of heart failure medications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... first robotic gym for the rehabilitation and functional motor sense evaluation of ... Italy . The first 30 robots will be available from June ... . The technology was developed and patented at the IIT laboratories and ... thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... ... Kapstone Medical is proud to announce that it has reached a ... develop and safeguard their latest innovations. The company has grown from a boutique ... in the United States and around the world. , Company Founder and President, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon is ... for analytical and scientific instruments. This year’s symposium, organized by the Pittcon 2018 ... Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, high ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... of 6” modular downlights designed to stay tightly sealed and perform efficiently for ... damp and wet location listings just aren't enough, such as: hospitals; behavioral health ...
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea arabica accounts ... and abiotic factors. During this educational webinar, participants will learn about the importance ... gain a better understanding of how genomics is important for coffee breeding improvement. ...
Breaking Biology Technology: