Navigation Links
Vanderbilt study shows therapeutic bacteria prevent obesity in mice
Date:7/22/2014

A probiotic that prevents obesity could be on the horizon. Bacteria that produce a therapeutic compound in the gut inhibit weight gain, insulin resistance and other adverse effects of a high-fat diet in mice, Vanderbilt University investigators have discovered.

"Of course it's hard to speculate from mouse to human," said senior investigator Sean Davies, Ph.D., assistant professor of Pharmacology. "But essentially we've prevented most of the negative consequences of obesity in mice, even though they're eating a high-fat diet."

Regulatory issues must be addressed before moving to human studies, Davies said, but the findings published in the August issue of the Journal of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the gut the gut microbiota to treat obesity and other chronic diseases.

Davies has a long-standing interest in using probiotic bacteria "friendly" bacteria like those in yogurt to deliver drugs to the gut in a sustained manner, in order to eliminate the daily drug regimens associated with chronic diseases.

In 2007, he received a National Institutes of Health Director's New Innovator Award to develop and test the idea.

"The NIH basically said, 'we like this idea, now make it work,'" Davies said. "The New Innovator Award was critical to our success."

Other studies have demonstrated that the natural gut microbiota plays a role in obesity, diabetes and cardiovascular disease.

"The types of bacteria you have in your gut influence your risk for chronic diseases," Davies said. "We wondered if we could manipulate the gut microbiota in a way that would promote health."

To start, the team needed a safe bacterial strain that colonizes the human gut. They selected E. coli Nissle 1917, which has been used as a probiotic treatment for diarrhea since its discovery nearly 100 years ago.

They genetically modified the E. coli Nissle strain to produce a lipid c
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vanderbilt-led team to develop microbrain to improve drug testing
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt diabetes researchers track cells ability to regenerate
4. Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
5. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
6. Law that regulates shark fishery is too liberal: UBC study
7. New study will help protect vulnerable birds from impacts of climate change
8. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
9. BYU study: Using a gun in bear encounters doesnt make you safer
10. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
11. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB ... Good Clinical Practices (GCP) audit to confirm its ... (FDA) regulations. This accomplishment enables HITLAB to conduct ... utilizing the highest principles for patient safety and ... improve global healthcare access, quality, and delivery with ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... series will hold a meeting on gene regulatory ... for the development of animal embryos, body parts, ... on four areas -- gene regulatory networks that ... processes; regulatory processes in complex multigenic systems; and ...
... is also available in French . ... involvement today with a $1-million donation to the Thinking ... (MNI), affiliated with McGill University and the McGill University ... to invest in people and expand facilities and services. ...
... in German . Genetically engineered products ... insulin. In future, gene therapy should make it possible to ... that they can address deficiencies to compensate for malfunctions in ... synthetic) DNA must be introduced into host cells, which is ...
Cached Biology News:Building the future -- 21st century nano tools to repair the nervous system 2Cells get sprayed 2
(Date:12/19/2014)... OR and Hershey, PA (PRWEB) December 19, 2014 ... Pink: BJCT), a leading developer and manufacturer of ... entered into an agreement with Immunomic Therapeutics, Inc. ... Biojector®-2000 needle-free injection device with its LAMP™ vaccine ... an option for an exclusive Worldwide license to ...
(Date:12/19/2014)... 19, 2014 BioPlus Specialty Pharmacy ... announces the promotion of Nick Maroulis, Pharm.D. to the ... Services. , In this position, Dr. Maroulis will ... managing the directors of our multi-site pharmacies as the ... 1997 and during that time he has served in ...
(Date:12/19/2014)... , Dec. 19, 2014  Roche (SIX: RO, ROG; ... Technologies, Inc. (Bina), a privately held company based ... USA. Bina provides a big data platform for ... (NGS) data. Bina,s proprietary on-market Genomic Management Solution, ... researchers to perform fast and scalable analyses to ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources Group ... grow at a 12 percent compound annual growth rate ... the aging population and the increasing adoption of dental ... will also spur demand for dental biomaterials ... implant and periodontal treatments. Other key findings ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3
... announced today that Mediasite products are eligible ... country the opportunity to receive the technology at a ... provide discounts between 20 and 90 percent to schools ... technology includes Internet services and access, telecommunications and internal ...
... find a new accessory among their standard travel gear ... new passports, mandated by State Department regulations, will feature ... information featured on the passport's physical page, which the ... passport is a more secure document than the passport ...
... Wave Technologies Inc. has reported financial results for the ... total revenue of $5.2 million and a net loss of ... to total revenue of $10.5 million and net income of ... clinical molecular diagnostic revenue of $4.0 million for the third ...
Cached Biology Technology:Passports to contain RFID chips next year 2
... convenient, and efficient Denatured protein concentration following ... spin column to make handling easy. The ... which were electro-eluted in their Denatured condition. ... high binding capacity fo all pH values. ...
... 220-240 V, is used to resolve 200 kb ... pulsed field gel electrophoresis (PFGE). The system includes ... x 13 cm casting stand with frame and ... screened cap, disposable plug molds, 12 feet of ...
... to knockout or alter genes on the ... Red/ET recombination allows the exchange of genetic information ... manner. An FRT-flanked kanamycin resistance marker cassette is ... to replace a gene on the E.coli ...
... is a state-of-the-art separation system using the ... The Eclipse integrates easily with Wyatts multi-angle ... as well as the Optilab DSP. The ... mass distributions of the particles/molecules separated by ...
Biology Products: