Navigation Links
Vanderbilt scientists invent world's smallest periscopes
Date:2/25/2009

A team of Vanderbilt scientists have invented the world's smallest version of the periscope and are using it to look at cells and other micro-organisms from several sides at once.

"With an off-the-shelf laboratory microscope you only see cells from one side, the top," says team member Chris Janetopoulos, assistant professor of biological sciences. "Not only can we see the tops of cells, we can view their sides as well something biologists almost never see."

The researchers have dubbed their devices "mirrored pyramidal wells." As the name implies, they consist of pyramidal-shaped cavities molded into silicon whose interior surfaces are coated with a reflective layer of gold or platinum. They are microscopic in dimension about the width of a human hair and can be made in a range of sizes to view different-sized objects. When a cell is placed in such a well and viewed with a regular optical microscope, the researcher can see several sides simultaneously.

"This technology is exciting because these mirrored wells can be made at very low cost, unlike other, more complex methods for 3D microscopy," says Assistant Professor of the Practice of Biomedical Engineering Kevin Seale.

According to Ron Reiserer, "This could easily become as ubiquitous as the microscope slide and could replace more expensive methods currently used to position individual cells." Reiserer is a lab manager at the Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE) who helped design the protocol used to make the micropyramids.

The Vanderbilt group is not the first to make microscopic pyramidal wells, but it is the first to apply them to make 3D images of microorganisms. In 2006, a group of scientists in England created pyramidal micromirrors and applied them to trapping atoms. And last spring researchers at the National Institute of Standards and Technology used similar structures to track nanoparticles.

The V
'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UCLA stem cells scientists make electrically active motor neurons from iPS cells
2. UCR scientists identify stem-cell genes that help form plant organs
3. Scientists mine drugs database for new diabetes treatment
4. Atmospheric scientists trace the human role in Indonesian forest fires
5. Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses
6. Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses
7. Life secret exposed: Scientists unlock mystery of molecular machine
8. Scientists find black gold amidst overlooked data
9. Marine scientists to assess environment before offshore drilling begins in US arctic waters
10. Scientists study full protein content of bakers yeast
11. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vanderbilt scientists invent world's smallest periscopes
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/2/2015)... 2015 According to preliminary estimates ... somewhat higher than 125 MSEK. This exceeds the guidance ... that revenues for Q1 2015 would be in line ... Q4 2014. The operating result for the first quarter ... interim report will as previously communicated be published on ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... SPRING HARBOR, N.Y. (Jan. 11, 2011) -- The ... a decade ago, has revolutionized biological research. But ... and linking basic biological processes to genomic information can ... new resource that provides easy access to information about ...
... One of the challenges of gene therapy - a set ... or RNA) - is to assure that this material arrives ... substantial amount along the way and without producing any undesired ... use of different types of vectors, molecules capable of transporting ...
... microscope, a coronavirus may resemble a spiny sea urchin or ... takes its name). Previously recognized as the second leading ... important diseases in many domesticated animals, a new disease form ... when the SARS coronavirus (CoV) surfaced in Asia. The ...
Cached Biology News:New user-friendly resource connects human genes to biological functions 2Nanodisk gene therapy 2New research aims to shut down viral assembly line 2New research aims to shut down viral assembly line 3New research aims to shut down viral assembly line 4New research aims to shut down viral assembly line 5
(Date:4/17/2015)... Reed Technology and Information Services ... management, preparation, and submission to the U.S. Food and ... new Lot Distribution Report (LDR) service for manufacturers of ... with the FDA’s new rule on electronic submission of ... the volume and timing of particular biologics introduced to ...
(Date:4/17/2015)... , April 17, 2015  Guggenheim Securities, the investment ... announced the hiring of William Tanner as ... Mr. Tanner will start work at Guggenheim in ... office. "Bill brings a wealth ... to our experienced and highly acclaimed healthcare team," said ...
(Date:4/17/2015)... 2015 LC Sciences LLC, a ... today that it is seeking beta testers for ... PCR based targeted sequencing technology. The system offers ... enables accurate detection of rare variants. It utilizes ... The company will collaborate with beta testers to ...
(Date:4/16/2015)... KYOTO and OSAKA, Japan ... iPS Cell Research Application (CiRA) of Kyoto University ... that they will work together to develop clinical ... such as heart failure, diabetes mellitus, neurological disorders ... iPS Cell Applications" (T-CiRA) is designed to expedite ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3
... tools and find the organisms to break down the ... the key step toward fermentation of those sugars ... and economically efficient before cellulosic biofuels can compete with ... any exploration of systems that involve largely unknown processes, ...
... Inc. (Nasdaq: ONTY ) will conduct a conference call to discuss its ... 4:30 p.m. Eastern time ( 1:30 p.m. Pacific time ). , ... To participate in the call by telephone, ... addition, the call will be webcast live and can be accessed on the ...
... CHICAGO , July 26 Advanced ... Board: ADLS), a biopharmaceutical company engaged in the discovery, ... areas of infection, oncology and respiratory diseases, today announced ... and option agreement with The University of British ...
Cached Biology Technology:New hydrolysis model promising tool in cellulosic biofuel studies 2New hydrolysis model promising tool in cellulosic biofuel studies 3Advanced Life Sciences Expands Antibiotic Pipeline 2Advanced Life Sciences Expands Antibiotic Pipeline 3Advanced Life Sciences Expands Antibiotic Pipeline 4
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
Anti-G-alpha-i 1 G-Protein Host: mouse monoclonal Species Reactivity: human, mouse, rat Applications: WB Storage: 4C...
Mouse monoclonal [DAPK-55] to DAP Kinase 1 ( Abpromise for all tested applications). entrezGeneID: 1612 SwissProtID: P53355...
KOR-1 (C-20)...
Biology Products: