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Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
Date:4/16/2014

l microvillar tip adhesion complex and destabilize the brush border. In a mouse missing harmonin, a model of Usher disease, they found poorly formed brush border in some parts of the intestines and no brush border in other areas.

"We think that patients with Usher disease probably have issues with brush border ultrastructure that are causing problems with homeostasis and leading to intestinal symptoms," Tyska said.

"Making the initial electron microscopy discovery, defining the molecular mechanism and then connecting it to human disease that's a scientific hat trick," he said.

Tyska and his colleagues are exploring whether a similar adhesive complex guides the assembly of brush border structures in other epithelial tissues, such as the kidneys.


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Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

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