Navigation Links
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
Date:4/16/2014

imaged intestinal tissue and found the same links a "web of connections" between the microvilli, Tyska said.

"We were excited by the idea that physical adhesion between microvilli might provide the driving force for growing and tightly packing the brush border," Tyska said.

The investigators suspected that proteins in the cadherin family calcium-dependent adhesion molecules that allow cells to stick together might mediate the interaction between microvilli. They had previously used proteomics technologies to define all of the proteins in the isolated brush border. The list included two candidates for microvillar tip adhesion: protocadherin-24 and mucin-like protocadherin.

In a series of studies, the team demonstrated that these two cadherins have a role in sticking microvilli together. Experimental reduction of protocadherin-24 in the cell culture model destroyed the brush border. Microvilli still formed, but they were not tightly packed and they had variable lengths.

"It's always been a question how microvilli achieve this remarkably uniform length," Tyska said. "Now it looks like the solution is simple they get tied together at the tips and one can't get past another. It's really straightforward."

In biochemical experiments, the researchers discovered that the cadherin molecules interacted with two proteins inside microvilli a motor protein connected to the cell cytoskeleton and an adapter protein called harmonin. These connections were required for the localization of the cadherins to the microvillar tips.

Interestingly, harmonin had been studied by other investigators for its role in linking protrusions on the inner ear hair cell a sensory structure involved in hearing. Genetic mutations that disable harmonin cause Usher syndrome, a form of inherited deaf-blindness. Patients with Usher syndrome also have poorly characterized intestinal disease.

Tyska and his colleagues realized that harmonin mutations might disrupt the intestina
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Vanderbilt diabetes researchers track cells ability to regenerate
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt-led team to develop microbrain to improve drug testing
4. New method isolates immune cells for researchers to study how they ward off oral diseases
5. Researchers describe 4 new species of killer sponges from the deep sea
6. Finding the switch: Researchers create roadmap for gene expression
7. UAlberta researchers examine metabolism in defective cells
8. MU researchers find rare fossilized embryos more than 500 million years old
9. Researchers show fruit flies have latent bioluminescence
10. Researchers develop novel molecular blood group typing technique
11. Researchers discover how the kissing disease virus hijacks human cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
(Date:7/27/2015)... July 27, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced that Huawei has selected the ... for its stylish smartwatch. Huawei chose the state-of-the-art ... low power and highly responsive human interface qualities ... designers also required a classic round watch face ...
(Date:7/21/2015)... Sweden , July 21, 2015 Today, ... FPC1025. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a leading smartphone manufacturer in China ... selected FPC1 02 5 for Axon ...
(Date:7/13/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ... today announced sampling of ClearPad ® 4300, ... (TDDI) product targeting smartphones and tablets. This new ... , best-in-class touch controller IP and systems ... in the company,s Japan Design Center. TDDI enables ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3
... new field study confirms that an invasive weed called ... suggesting it will continue to spread across much of ... acres of grazing land almost worthless. The research, ... Research Service, was one of the most comprehensive studies ...
... What: , The 33rd CTRC-AACR San Antonio ... prevention, epidemiological, laboratory, translational and clinical breast cancer research. ... pipeline, new approaches with existing agents and emerging biology ... To help you plan your coverage of the symposium, ...
... growing potatoes, at least for growing seed potatoes. Newco ... together with Neiker-Tecnalia (the Basque Institute for Agricultural Research ... of a novel system known as aeroponics. What ... given that never before in this country the first ...
Cached Biology News:Invading weed threatens devastation to western rangelands 2Invading weed threatens devastation to western rangelands 3Newco produces seed potatoes in the open air 2Newco produces seed potatoes in the open air 3
(Date:7/30/2015)... 2015   Aratana Therapeutics, Inc . (NASDAQ: ... on the licensing, development and commercialization of innovative ... its strategic partner VetStem Biopharma, Inc. has shared ... AT-016, an adipose-derived allogeneic stem cell product exclusively ... pain in dogs. The double-blinded, multi-site, ...
(Date:7/30/2015)... customers across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ... and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... July 30, 2015 HIGHLIGHTS:Q2 2015 ... 2014) , Reported sales were $697 million compared ... Sales grew organically by 8%, and changes in foreign ... increased sales by 1%. , By business unit, ... Applied and 11% in SAFC Commercial. , Reported ...
(Date:7/30/2015)... ... July 30, 2015 , ... As part of its 2015 growth plan and as ... technical service business units, Whitehouse Laboratories is pleased to announce that it has ... the Container Center of Excellence and will be strictly dedicated to basic USP 51, USP ...
Breaking Biology Technology:Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... "Just what is this Web 2.0?" , ,I'm not the ... label everything from start-ups ("Oh, that's a Web 2.0 company") to ... technology evolution timeline ("we're in the Web 2.0 era"). , ,Not ... ,For Romasha Roy Choudhury of Cynapse, Web 2.0 is, ...
... In the interest of its own efficiency, the U.S. ... would restrict the ability of patent applicants to file ... your approach to claiming your invention. , ,The first ... nation (RCEs), and the filing of Multiple similar applications. ...
... - Merge Technologies, Inc. has received a ... that the company's failure to file financial reports for the ... basis for delisting its common stock from NASDAQ. , ... appeared before the NASDAQ Listing Qualifications Panel to request that ...
Cached Biology Technology:Readers' Web 2.0 definitions 2Readers' Web 2.0 definitions 3Readers' Web 2.0 definitions 4Patent rule changes are in the wind 2Patent rule changes are in the wind 3
... Ac-DEVD-CHO is an ... activity. The concentration of ... caspase activity must be ... system. Ten micromolar inhibitor ...
TUNEL Apoptosis Detection Kit...
Human RELT/TNFRSF19L Affinity Purified Polyclonal Ab...
homeo box D3, mRNA...
Biology Products: