Navigation Links
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
Date:4/16/2014

imaged intestinal tissue and found the same links a "web of connections" between the microvilli, Tyska said.

"We were excited by the idea that physical adhesion between microvilli might provide the driving force for growing and tightly packing the brush border," Tyska said.

The investigators suspected that proteins in the cadherin family calcium-dependent adhesion molecules that allow cells to stick together might mediate the interaction between microvilli. They had previously used proteomics technologies to define all of the proteins in the isolated brush border. The list included two candidates for microvillar tip adhesion: protocadherin-24 and mucin-like protocadherin.

In a series of studies, the team demonstrated that these two cadherins have a role in sticking microvilli together. Experimental reduction of protocadherin-24 in the cell culture model destroyed the brush border. Microvilli still formed, but they were not tightly packed and they had variable lengths.

"It's always been a question how microvilli achieve this remarkably uniform length," Tyska said. "Now it looks like the solution is simple they get tied together at the tips and one can't get past another. It's really straightforward."

In biochemical experiments, the researchers discovered that the cadherin molecules interacted with two proteins inside microvilli a motor protein connected to the cell cytoskeleton and an adapter protein called harmonin. These connections were required for the localization of the cadherins to the microvillar tips.

Interestingly, harmonin had been studied by other investigators for its role in linking protrusions on the inner ear hair cell a sensory structure involved in hearing. Genetic mutations that disable harmonin cause Usher syndrome, a form of inherited deaf-blindness. Patients with Usher syndrome also have poorly characterized intestinal disease.

Tyska and his colleagues realized that harmonin mutations might disrupt the intestina
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Vanderbilt diabetes researchers track cells ability to regenerate
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt-led team to develop microbrain to improve drug testing
4. New method isolates immune cells for researchers to study how they ward off oral diseases
5. Researchers describe 4 new species of killer sponges from the deep sea
6. Finding the switch: Researchers create roadmap for gene expression
7. UAlberta researchers examine metabolism in defective cells
8. MU researchers find rare fossilized embryos more than 500 million years old
9. Researchers show fruit flies have latent bioluminescence
10. Researchers develop novel molecular blood group typing technique
11. Researchers discover how the kissing disease virus hijacks human cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
(Date:12/10/2014)... 2014 Research and Markets ( ... "Biometrics Market in Japan 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of biometrics ... banking and upgradation of the driver,s license is ... market. Besides the aforementioned projects, biometrics is being ...
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... 2008 -- Sirtris, a GlaxoSmithKline company focused on discovering ... aging such as Type 2 Diabetes, is included among ... of Cell Metabolism that mice treated at ... health improvement, including improved bone health, a reduction in ...
... vital information to relief workers in Myanmar throughout a ... Nargis that hit the country on 2 and 3 ... Office for the Coordination of Humanitarian Affairs (OCHA) asked ... to as ,the Charter, for support by providing immediate ...
... and size of microscopic three-dimensional structures built out of ... and his former graduate student Bryan Kaehr at The ... fabricated a variety of detailed three-dimensional microstructures, known as ... bend the hydrogels by altering the chemistry of the ...
Cached Biology News:Long-term study of middle-aged mice shows 2Long-term study of middle-aged mice shows 3Extended cyclone relief efforts aided from space 2Extended cyclone relief efforts aided from space 3'Smart' materials get smarter with ability to better control shape and size 2'Smart' materials get smarter with ability to better control shape and size 3
(Date:12/17/2014)... Audacity, a leading California-based health and science ... Huntsworth Health Group, is proud to announce the addition ... role, Gonzales will serve as Senior Vice President of ... welcome a talent of Jamie’s caliber to the Audacity ... is a proven healthcare innovation leader and brand management ...
(Date:12/17/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) ... changes to Martine Rothblatt , Ph.D,s compensation program. ... United Therapeutics announced the promotion of Roger Jeffs ... David Zaccardelli , Pharm.D. to Executive Vice President ... Dr. Rothblatt,s title will change from Chairman and Chief ...
(Date:12/17/2014)... FRANCISCO, Calif. , Dec. 17, 2014 /PRNewswire/ ... of a Phase 2 study evaluating the investigational ... treatment of patients with severe, chronic itch who ... standard of care, including topical steroids and antihistamines. ... percent change in Visual Analog Scale (VAS) itch ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce that the ... PVM technology , is now available. The new ... continuously captures high-resolution images under a wide range ... a report pairing the most relevant images to ... compelling blend of high resolution images and trend ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... eight port right-angle BNC connectors to its product line. The ... for applications where a number of single or dual port BNC ... ... (PRWEB) April 29, 2009 -- Regal Electronics has added four, six ...
... - Strong Focus on the Markets of Pharma & Life Science ... of EUR0.40 per Share , The Annual ... per share following the record year in 2008. , ... results.,Gerresheimer achieved sales of EUR1.06 billion (prior year EUR957.7m) and,operating results ...
... MSEDMONTON, April 29 /PRNewswire-FirstCall/ - BioMS Medical Corp (TSX: MS), ... today announced that Mr. Kevin Giese, President and CEO, will ... development of a world class technology sector" as part of ... WHEN: Monday May 4th at ...
Cached Biology Technology:Regal Introduces Four, Six and Eight Port Filtered and Un-Filtered Right Angle BNC Connectors 22008 a Record Year for Gerresheimer 2BioMS Medical to present at Alberta Economic Forum in Geneva 2
... PCR Spots, Oligo Spots and complementary RNA ... microarray experiments. Use for glass array printing ... for reverse transcription, cDNA labeling, hybridization stringency ... Control PCR Spots and Oligo Spots, ...
Kit for Detection of Mitochondrial Membrane Potential...
EGTA, 50 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
MOUSE ANTI HUMAN C-MYC aa171-188...
Biology Products: