Navigation Links
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
Date:4/16/2014

imaged intestinal tissue and found the same links a "web of connections" between the microvilli, Tyska said.

"We were excited by the idea that physical adhesion between microvilli might provide the driving force for growing and tightly packing the brush border," Tyska said.

The investigators suspected that proteins in the cadherin family calcium-dependent adhesion molecules that allow cells to stick together might mediate the interaction between microvilli. They had previously used proteomics technologies to define all of the proteins in the isolated brush border. The list included two candidates for microvillar tip adhesion: protocadherin-24 and mucin-like protocadherin.

In a series of studies, the team demonstrated that these two cadherins have a role in sticking microvilli together. Experimental reduction of protocadherin-24 in the cell culture model destroyed the brush border. Microvilli still formed, but they were not tightly packed and they had variable lengths.

"It's always been a question how microvilli achieve this remarkably uniform length," Tyska said. "Now it looks like the solution is simple they get tied together at the tips and one can't get past another. It's really straightforward."

In biochemical experiments, the researchers discovered that the cadherin molecules interacted with two proteins inside microvilli a motor protein connected to the cell cytoskeleton and an adapter protein called harmonin. These connections were required for the localization of the cadherins to the microvillar tips.

Interestingly, harmonin had been studied by other investigators for its role in linking protrusions on the inner ear hair cell a sensory structure involved in hearing. Genetic mutations that disable harmonin cause Usher syndrome, a form of inherited deaf-blindness. Patients with Usher syndrome also have poorly characterized intestinal disease.

Tyska and his colleagues realized that harmonin mutations might disrupt the intestina
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Vanderbilt diabetes researchers track cells ability to regenerate
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt-led team to develop microbrain to improve drug testing
4. New method isolates immune cells for researchers to study how they ward off oral diseases
5. Researchers describe 4 new species of killer sponges from the deep sea
6. Finding the switch: Researchers create roadmap for gene expression
7. UAlberta researchers examine metabolism in defective cells
8. MU researchers find rare fossilized embryos more than 500 million years old
9. Researchers show fruit flies have latent bioluminescence
10. Researchers develop novel molecular blood group typing technique
11. Researchers discover how the kissing disease virus hijacks human cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
(Date:9/2/2014)... University of Warwick in the UK and the Ruhr-University ... Early Human Development , has found that both ... and the use of mechanical ventilation are key indicators ... abilities are crucial for lifelong academic attainment. Impairments in ... studies of children who are born very preterm (before ...
(Date:9/2/2014)... birds, also known as perching birds, that migrate by ... do in autumn to reach their destinations. This seasonal ... that only make short migratory flights, says researcher Cecilia ... Behavioral Ecology and Sociobiology . , Nilsson, ... a tracking radar to measure over three years the ...
(Date:9/2/2014)... spiky legs and their propensity for eating anything, including ... And now research from North Carolina State University finds ... across the eastern United States. , "The good news ... kind of threat to humans," says Dr. Mary Jane ... author of a paper about the research. , The ...
Breaking Biology News(10 mins):Mechanical ventilation a key indicator for pre-term children's math problems 2Migrating birds sprint in spring, but take things easy in autumn 2Researchers find Asian camel crickets now common in US homes 2
... Exotic bacteria that do not rely on oxygen may have ... early atmosphere, according to a theory that UChicago researcher Albert ... volcanic crater in Siberia. He has found that bacteria ... a surprising twist that scientists must take into account as ...
... WASHINGTON, April 26, 2011 The American Chemical Society ... " Global Challenges/Chemistry Solutions " podcast series showcasing ... friendly production of a key ingredient used to make ... and accompanying website focus on a new way to ...
... Group announced today that four individuals, representing Chile, Mexico ... in Marine Conservation. The 2011 Pew Marine ... dolphin populations, measure the economic and ecological tradeoffs of ... scientific foundation for the establishment of marine protected areas ...
Cached Biology News:Cold case: Siberian hot springs reveal ancient ecology 2Cold case: Siberian hot springs reveal ancient ecology 3Pew announces 2011 recipients of distinguished marine conservation fellowship 2
(Date:9/2/2014)... Quincy, MA (PRWEB) September 02, 2014 ... announced today the signage of a distribution agreement ... Azelis is now distributing Myriant’s bio-succinic acid in ... Kingdom and Ireland, targeting customers in the industrial ... chemical distribution powerhouse, Azelis offers a far-reaching chemical ...
(Date:9/2/2014)... Sept. 2, 2014  Xencor, Inc. (NASDAQ: ... engineered monoclonal antibodies for the treatment of autoimmune ... announced the appointment of Debra Zack , ... appointment of Lloyd Rowland , senior vice ... "Debra,s expertise in biologics clinical development ...
(Date:9/2/2014)... /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... of three large odour control systems for waste water treatment ... orders are consistent with the market resurgence in ... and CEO. "After a difficult period of restraint in our ... see sales growth. Our lower cost structure, technology improvements and ...
(Date:9/2/2014)... Massachusetts , September 2, 2014 ... to BioData,s research and lab management services  ... management service, is pleased to announce the appointment of ... Culot most recently served as VP Marketing and Business ... life science research and clinical applications. Previously, ...
Breaking Biology Technology:Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3Louis Culot Appointed as BioData's CEO 2
... Monogram,Biosciences, Inc. (Nasdaq: MGRM ) announced today ... Financial Officer, is,scheduled to present a corporate overview ... 13, 2007 at 11:00 a.m. (Eastern Time) at,the ... access the live audio broadcast or the subsequent ...
... CALL DATE: Oct. 31, 2007 TIME: 8:30 a.m. Eastern Time HOST: Dr. ... ... KNDL ),will conduct a telephone conference call and simultaneous webcast Oct. 31,at ... 2007. A question and answer session will follow. (Logo: http://www.newscom.com/cgi-bin/prnh/20030429/KNDLLOGO ...
... leading,management consulting firm specializing in the pharmaceutical and biotech,industries, ... of the best,places to work in the Research Triangle ... ranking third among midsize companies. The award,was presented to ... to Work luncheon and awards ceremony on September 27, ...
Cached Biology Technology:Monogram Biosciences to Present at the JMP Securities Healthcare Conference 2Kendle Invites You to Attend Its Third Quarter 2007 Earnings Conference Call and Webcast 2Campbell Alliance Named 'Best Place to Work' by Triangle Business Journal 2
Recombinant Feline IL-2, CF...
Recombinant Equine IL-4, CF...
Recombinant Rat Leptin, CF...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: