Navigation Links
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
Date:4/16/2014

The "brush border" a densely packed array of finger-like projections called microvilli covers the surfaces of the cells that line our intestines.

Vanderbilt University researchers have now discovered how intestinal cells build this specialized structure, which is critical for absorbing nutrients and defending against pathogens. The findings, published April 10 in the journal Cell, reveal a role for adhesion molecules in brush border assembly and increase our understanding of intestinal pathologies associated with inherited and infectious diseases.

Pathogens that destroy the intestinal brush border cause diarrhea and death a particular problem in communities that do not have safe water supplies.

"Without a fully functional brush border that has enough surface area and absorptive capacity, you can't survive," said Matthew Tyska, Ph.D., associate professor of Cell and Developmental Biology and senior author of the Cell paper. "Our basic science discoveries provide a framework for thinking about how to control intestinal surface morphology and how to repair it."

Despite the essential role of the brush border, its assembly has remained a mystery. Using scanning electron microscopy, Tyska and postdoctoral fellow Scott Crawley, Ph.D., followed the generation of the brush border over time in an epithelial cell culture model.

They found that as the microvilli begin to emerge, they stick to each other at their tips and form small teepee-like clusters. Over time, these clusters grow to include more and more microvilli, until the entire cell surface is covered by microvilli of uniform height.

"This was really the fundamental observation that gave rise to the rest of the project that these microvilli come out of the cell surface and stick together at the tips," Tyska said.

When the investigators closely examined the electron micrographs, they saw thread-like links connecting microvilli at their tips. One of their collaborators
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Vanderbilt diabetes researchers track cells ability to regenerate
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt-led team to develop microbrain to improve drug testing
4. New method isolates immune cells for researchers to study how they ward off oral diseases
5. Researchers describe 4 new species of killer sponges from the deep sea
6. Finding the switch: Researchers create roadmap for gene expression
7. UAlberta researchers examine metabolism in defective cells
8. MU researchers find rare fossilized embryos more than 500 million years old
9. Researchers show fruit flies have latent bioluminescence
10. Researchers develop novel molecular blood group typing technique
11. Researchers discover how the kissing disease virus hijacks human cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
(Date:9/17/2014)... New research from the Copenhagen Centre for Social Evolution ... evolutionary theory that birth weight and -length can partially ... disorders such as autism and schizophrenia later in life. ... births, and subsequent hospital diagnoses for up to 30 ... factors. The study is published today in the ...
(Date:9/17/2014)... obtained the first partial genome sequence of an ancient ... the site of the Montsoriu Castle in Girona, the ... related to today,s Iberian pig. Researchers also discard the ... pigs. , The study, published in Heredity , ... and particularly on that of the Iberian breed, considered ...
(Date:9/17/2014)... retinoblastoma protein gene are a leading cause of eye ... fruit fly eyes to unlock the secrets of this ... on the cover of the current issue of the ... researchers provide the first detailed examination of a set ... cancer gene, said Irina Pushel, MSU undergraduate and co-author. ...
Breaking Biology News(10 mins):Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Iberian pig genome remains unchanged after 5 centuries 2Abnormal properties of cancer protein revealed in fly eyes 2
... North Grafton, Mass., August 10, 2011 Second graders ... to maintain their reading skills during the dog days of ... Cummings School of Veterinary Medicine at Tufts University. In ... second-grade students with a range of reading aptitudes and attitudes ...
... structure of a complex formed when a protein binds ... how an antibiotic-producing organism controls resistance to its own ... antibiotic producers regulate export to prevent self-toxicity. , The ... complex and highly regulated process, not least because the ...
... , Invasive species cost an estimated $1.4 trillion annually ... second only to habitat loss as a threat to ... invasive species, the question of why some species are ... Dr. Alison Bennett and Dr. Sharon Strauss at the ...
Cached Biology News:Days spent reading to dogs during summer may help avoid decline of reading skills 2Student brings home new expertise to answer question in antibiotic resistance 2Student brings home new expertise to answer question in antibiotic resistance 3Waging war on invasive plant species: Effects of invasives persist even after removal 2
(Date:9/18/2014)... diseases that afflict skeletal growth through abnormalities in ... fetal stage and is caused by genetic mutations. ... factor receptor 3 (FGFR3) has been associated with ... a skeletal dysplasia that cause serious respiratory problems ... (ACH), which causes stunted growth and other complications ...
(Date:9/18/2014)... Scientists at USC have developed a new microscopy ... in living animals at higher-than-ever resolution. , Dubbed ... allows imaging resolutions that are an order of ... insights into the behavior of biomolecules at the ... Sept. 18 by Nature Communications , the ...
(Date:9/18/2014)... Silicon-valley Electronic Data Capture (EDC) provider ... , the latest addition to Clinovo’s CRO Partnership Program. ... (CRO) Program, Clinovo further expands its global reach to ... training, we are now able to build studies on ... can also rely on Clinovo to fully support the ...
(Date:9/18/2014)... Whitehouse Laboratories is pleased to announce that ... has acquired an additional 4,000 square feet of dedicated ... adjacent to its current package testing facility. The official ... Whitehouse Labs is in the process of upgrading the ... testing. The prime location enables Whitehouse Labs to immediately ...
Breaking Biology Technology:Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 3Whitehouse Labs Announces Package Testing Laboratory Expansion 2Whitehouse Labs Announces Package Testing Laboratory Expansion 3Whitehouse Labs Announces Package Testing Laboratory Expansion 4
... of Pittsburgh School of Dental Medicine are piecing together ... to novel nanoscale approaches to developing biomaterials. The findings ... of the National Academy of Sciences . Dental ... and combines high hardness with resilience, said Elia Beniash, ...
... NeoStem, Inc. (NYSE Amex: NBS ) ("NeoStem" ... focus on cell based therapeutics development, today announced that ... Program (PRMRP) of the Office of the Congressionally Directed ... be applied towards funding the Company,s VSEL™ Technology. This ...
... testing within the pharmaceutical and cosmetic industries and companies ... their products are safe to use. Research published in ... demonstrates that the response of laboratory grown human cells ... or non-sensitizing, and can even predict the strength of ...
Cached Biology Technology:NeoStem Announces the Receipt of Over $1,700,000 in DOD Funding for its VSEL™ Technology Being Developed to Treat Osteoporosis 2NeoStem Announces the Receipt of Over $1,700,000 in DOD Funding for its VSEL™ Technology Being Developed to Treat Osteoporosis 3NeoStem Announces the Receipt of Over $1,700,000 in DOD Funding for its VSEL™ Technology Being Developed to Treat Osteoporosis 4Cell-based alternative to animal testing 2
Rabbit polyclonal antibody to NMDA NR2B [Tyr1336]...
... DeCypher combines enterprise-scale sequence analysis software with the ... analyses. With DeCypher, you can perform searches like ... vs NCBI NT database in under 6 days ... genomic DNA Use HMM analysis to ...
... Reagent A: MTT, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide), 50mg/vial. ... is cleaved by living cells to yield ... requires active mitochondria, and even freshly dead ... MTT. Reagent A is a component of ...
Mouse monoclonal antibody to FMN2 - formin 2...
Biology Products: