Navigation Links
Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
Date:8/10/2011

An international team of scientists has identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of an important and very debilitating neurological disease.

Multiple sclerosis (MS), one of the most common neurological conditions among young adults, affects around 2.5 million individuals worldwide. It is a chronic disease that attacks the central nervous system (CNS), which includes the brain, spinal cord and optic nerves, and can cause severe symptoms such as paralysis or loss of vision.

Vanderbilt University Medical Center's Center for Human Genetics Research (CHGR) played an important role in the research published today in the journal Nature, which represents the largest MS genetics study ever undertaken and effectively doubles the number of genes known to be associated with the disease.

"We now know just how complex multiple sclerosis is," said Jonathan Haines, Ph.D., director of the CHGR and one of the principal researchers in this effort. "These new genes give us many new clues as to what is happening in MS and will guide our research efforts for years to come."

Researchers studied the DNA from 9,772 individuals with multiple sclerosis and 17,376 unrelated healthy controls. They were able to confirm 23 previously known genetic associations and identified a further 29 new genetic variants (and an additional five that are strongly suspected) conferring susceptibility to the disease.

Many genes implicated in the study are relevant to the immune system, shedding light onto the immunological pathways that underlie the development of multiple sclerosis.

One-third of the genes identified in the study have previously been implicated in playing a role in other autoimmune diseases such as Crohn's Disease and Type 1 diabetes, Haines said.

Previous studies have also suggested a link between vitamin D deficiency and an increased risk of multiple sclerosis; researchers in this study identified two genes involved in the metabolism of vitamin D, providing additional insight into a possible link between genetic and environmental risk factors.

The international team led by the Universities of Cambridge and Oxford, and funded by the Wellcome Trust, includes contributions from nearly 250 researchers as members of the International Multiple Sclerosis Genetics Consortium and the Wellcome Trust Case Control Consortium.


'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related biology news :

1. Vanderbilt-Ingram Cancer Center launches online genetic research tool
2. Scripps Research and Vanderbilt to launch joint institute
3. Vanderbilt engineers play key role in new DOE energy frontier research center
4. Vanderbilt scientists invent worlds smallest periscopes
5. USDA researchers, collaborators sequence genomes of fungi that threaten wheat, poplars
6. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
7. Worlds largest sheep an international traveler
8. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
9. 19th Conference of the International Society for Sexually Transmitted Disease Research
10. Girls Puberty Book Project provides an international model for promoting female health in Africa
11. Office of Naval Research Global connecting with international naval community at MAST Europe 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... July 20, 2017 Delta (NYSE: DAL ) customers ... Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft ... Delta,s biometric boarding pass ... is now integrated into the boarding process to allow eligible Delta ...
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... ... the worldwide rights to SQuEEZ heart function analysis software, and an associated pending ... application was filed April 10, 2014 and uses high resolution cardiac CT to ...
(Date:7/26/2017)... ... 26, 2017 , ... Franz Inc ., an early ... for Knowledge Graphs, today announced Gruff v7.0 , the industry’s leading Graph ... and graph experts the ability to visually build queries and explore connections as ...
(Date:7/26/2017)... 2017 /PRNewswire/ - Caprion Biosciences Inc., a world leading specialty CRO ... proteins predictive of early stage (latent) Mycobacterium tuberculosis (Mtb) infection ... monitoring (MRM-MS) platform. ... Caprion Biosciences Inc. (CNW Group/Caprion Biosciences) ... The new data, recently published ...
(Date:7/26/2017)... Baltimore, MD (PRWEB) , ... July 25, 2017 , ... ... CEO David West Jr. will be a featured panelist at 2017 MedCity CONVERGE. His ... startups in the diagnostics, biopharmaceuticals, medical technology, and emerging technology (AI, VR, Big Data) ...
Breaking Biology Technology: