Navigation Links
Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis

An international team of scientists has identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of an important and very debilitating neurological disease.

Multiple sclerosis (MS), one of the most common neurological conditions among young adults, affects around 2.5 million individuals worldwide. It is a chronic disease that attacks the central nervous system (CNS), which includes the brain, spinal cord and optic nerves, and can cause severe symptoms such as paralysis or loss of vision.

Vanderbilt University Medical Center's Center for Human Genetics Research (CHGR) played an important role in the research published today in the journal Nature, which represents the largest MS genetics study ever undertaken and effectively doubles the number of genes known to be associated with the disease.

"We now know just how complex multiple sclerosis is," said Jonathan Haines, Ph.D., director of the CHGR and one of the principal researchers in this effort. "These new genes give us many new clues as to what is happening in MS and will guide our research efforts for years to come."

Researchers studied the DNA from 9,772 individuals with multiple sclerosis and 17,376 unrelated healthy controls. They were able to confirm 23 previously known genetic associations and identified a further 29 new genetic variants (and an additional five that are strongly suspected) conferring susceptibility to the disease.

Many genes implicated in the study are relevant to the immune system, shedding light onto the immunological pathways that underlie the development of multiple sclerosis.

One-third of the genes identified in the study have previously been implicated in playing a role in other autoimmune diseases such as Crohn's Disease and Type 1 diabetes, Haines said.

Previous studies have also suggested a link between vitamin D deficiency and an increased risk of multiple sclerosis; researchers in this study identified two genes involved in the metabolism of vitamin D, providing additional insight into a possible link between genetic and environmental risk factors.

The international team led by the Universities of Cambridge and Oxford, and funded by the Wellcome Trust, includes contributions from nearly 250 researchers as members of the International Multiple Sclerosis Genetics Consortium and the Wellcome Trust Case Control Consortium.


Contact: Craig Boerner
Vanderbilt University Medical Center

Related biology news :

1. Vanderbilt-Ingram Cancer Center launches online genetic research tool
2. Scripps Research and Vanderbilt to launch joint institute
3. Vanderbilt engineers play key role in new DOE energy frontier research center
4. Vanderbilt scientists invent worlds smallest periscopes
5. USDA researchers, collaborators sequence genomes of fungi that threaten wheat, poplars
6. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
7. Worlds largest sheep an international traveler
8. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
9. 19th Conference of the International Society for Sexually Transmitted Disease Research
10. Girls Puberty Book Project provides an international model for promoting female health in Africa
11. Office of Naval Research Global connecting with international naval community at MAST Europe 2011
Post Your Comments:
(Date:11/18/2015)... 18, 2015 --> ... new market report titled  Gesture Recognition Market - Global ... - 2021. According to the report, the global gesture recognition market was ... to reach US$29.1 bn by 2021, at a CAGR ... North America dominated the global gesture recognition ...
(Date:11/16/2015)... Calif. , Nov 16, 2015  Synaptics ... of human interface solutions, today announced expansion of ... TouchView ™ touch controller and display driver ... revolution of smartphones. These new TDDI products add ... TD4100 (HD resolution), TD4302 (WQHD resolution), and TD4322 ...
(Date:11/10/2015)... 10, 2015  In this report, the ... of product, type, application, disease indication, and ... report are consumables, services, software. The type ... biomarkers, efficacy biomarkers, and validation biomarkers. The ... diagnostics development, drug discovery and development, personalized ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("ProMetic" ... , President and Chief Executive Officer of ProMetic, will be ... th Annual Healthcare Conference to be held at the ... st , at 8.50am (ET) and ProMetic,s management team ... presentation will be available live via a webcast accessible at ...
(Date:11/24/2015)... ... ... Whitehouse Laboratories is pleased to announce that it has completed construction on a ... basic USP 61, USP 62 and USP 51 testing specific to raw materials and ... testing performed by one supplier. Management has formally announced that the facility ...
(Date:11/23/2015)... , ... November 23, 2015 , ... ... for the development of its Nexera UC Unified Chromatography system. The award from ... technically significant new products of the year in the analytical and testing category. ...
(Date:11/23/2015)... , Nov. 23, 2015  CryoLife, Inc. (NYSE: CRY ... on cardiac and vascular surgery, announced today that it will ... Healthcare Conference on Wednesday, December 2, 2015 at The New ... . Pat Mackin , President and Chief Executive ... Chief Executive Officer. --> A live webcast ...
Breaking Biology Technology: