Navigation Links
Vancouver Island has one of the highest rates of Cryptococcus infection in the world
Date:5/4/2010

Calgary, AB Cryptococcus disease is a rare but serious infection resulting from inhaling a toxic fungus often found in fir trees. Approximately 250 people have been infected with the disease in British Columbia since its emergence in 1999. The disease can cause meningitis, pneumonia and in 10 per cent of cases it can lead to death.

Little is known about how the fungus leaves the bloodstream and enters the brain; however, researchers at the University of Calgary's Faculty of Medicine have made a key observation. Using a mouse model, Drs. Meiqing Shi and Christopher Mody and their team noticed that a class of therapeutic drugs already approved for other medical uses could stop the fungus from crossing the brain blood barrier and therefore reduce brain infection. The finding was published this week in the May edition of the Journal of Clinical Investigation.

"We would love to partner with someone and study this further," says Mody, a member of the Snyder Institute of Infection, Immunity and Inflammation and senior author on the study "While the therapy was tested in mice we do think it could ultimately transition to humans. The class of drugs we used in the study is already approved for use in humans for other conditions."

If this new treatment is approved for Cryptococcus infection for humans it could prevent further spread to the brain but it would not replace current therapies, which include an aggressive treatment of two-drugs taken for a period of many months.

Cryptococcus first appeared on Vancouver Island in 1999, and has spread into the B.C. lower mainland as well as down the Pacific coast into Washington and Oregon. It can take several months for respiratory symptoms to appear and fortunately not many people exposed to the fungus become ill.

"The type of Cryptococcus on Vancouver Island comes from warm climates such as Northern Australia and is particularly dangerous even in healthy people so it is very important to study the emergence of this infectious disease," says Paul Kubes, PhD, a co-author on this study and Director of the Snyder Institute for Infection, Immunity and Inflammation .

There are 37 different species of Cryptococcus and various strains have been affecting people in Africa and Australia. Vancouver Island has only recently been infected with the fungus and has one of the highest rates of infection in the world.


'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Related biology news :

1. Ancient whale fall from Californias Año Nuevo Island one of youngest, most complete known
2. Ancient whale fall from Californias Ao Nuevo Island one of youngest, most complete known
3. Island monkeys do not recognize big cat calls
4. First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills
5. Rats on islands disrupt ecosystems from land to sea, researchers find
6. Rare North Island brown kiwi hatches at the Smithsonians National Zoo
7. Smithsonian coral biodiversity survey of Panamas Pearl Islands
8. Sky islands: metaphor or misnomer?
9. Study of islands reveals surprising extinction results
10. Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
11. UC Riverside scientist to explore how vegetation affects urban heat islands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... Republic , February 8, 2016 ... global payment platform which presents innovation for clients, ... Authentication feature called VoiceKey. --> Worldcore ... which presents innovation for clients, comfort and unbeatable ... VoiceKey. --> Worldcore is ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... is apparently one of the most popular hubs ... Project, MetaHIT and other huge studies of human ... that past few years, the microbiome space has ... applied biomedical research. This report focuses on ...
(Date:2/3/2016)... , February 3, 2016 ... market research report "Automated Fingerprint Identification System Market by ... Search), Application (Banking & Finance, Government, Healthcare, and Transportation) ... MarketsandMarkets, the market is expected to be worth USD ... 21.0% between 2015 and 2020. The transformation and technology ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 2016  Spectra BioPharma Selling Solutions (Spectra) is ... biopharma companies the experience, expertise, operational delivery and ... sales teams. Created in concert with industry leading ... strategic and tactical needs of its clients by ... both personal and non-personal promotion. ...
(Date:2/11/2016)...   BioInformant announces the February 2016 release ... Opportunities, Tools, and Technologies – Market Size, Segments, Trends, ... The first and only market ... BioInformant has more than a decade of historical information ... stem cell type. This powerful 175 page global strategic ...
(Date:2/10/2016)... Early-career researchers from ... , Uganda and Yemen ... nutrition   Indonesia , Nepal ... Yemen are being honored for their accomplishments in ... celebrated for mentoring young women scientists who are pursuing careers in agriculture, ...
(Date:2/10/2016)... -- IsoRay, Inc. (NYSE MKT: ISR), a medical technology company ... for the treatment of prostate, brain, lung, head and ... for the second quarter and six months of fiscal ... --> --> Revenue was $1.19 ... ended December 31, 2015, a 12% increase compared to ...
Breaking Biology Technology: