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Vaginal gel with integrase inhibitor shows promise in monkeys
Date:5/23/2010

PITTSBURGH, May 23 Researchers testing a vaginal microbicide based on a new type of anti-HIV drug found it provided monkeys significant protection against infection with a virus similar to HIV, according to a study reported at the International Microbicides Conference in Pittsburgh today.

The study is the first of a gel with an integrase inhibitor, one of the latest additions to the arsenal of drugs for the treatment of HIV but just one of the many compounds or drug combinations that researchers are hoping will be a stronghold for HIV prevention. These include different types of antiretrovirals (ARVs) than those currently being evaluated in clinical trials of ARV-based microbicides or oral pre-exposure prophylaxis (PrEP).

Microbicides are substances designed to prevent the sexual transmission of HIV when applied topically on the inside of the rectum or vagina, whereas oral PrEP is an approach involving the use of ARVs drugs by HIV-negative people to reduce their risk of acquiring HIV. PrEP trials are focused on two drugs, tenofovir and Truvada , from a class of ARVs called nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). The roster of ongoing microbicide trials are of gels that contain either tenofovir, dapivirine or UC781. Dapivirine and UC781 are non-nucleoside reverse transcriptase inhibitors, a close cousin to the NRTI class of ARVs.

M2010 runs May 22-25 at Pittsburgh's David L. Lawrence Convention Center. Nearly 1,000 participants from 47 different countries are attending to hear about the latest developments in HIV prevention research. Summaries of some of the studies looking at new drugs and drug combinations are provided below.

Vaginal gel with integrase inhibitor shows promise in monkeys

An experimental vaginal microbicide gel containing a drug from a class of antiretrovirals (ARVs) not previously examined for use as a topical prevention approach provided significant protection
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Contact: Lisa Rossi
rossil@upmc.edu
412-916-3315
Microbicides 2010 (International Conference on Microbicides)
Source:Eurekalert

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