Navigation Links
Vaccines to boost immunity where it counts, not just near shot site
Date:1/22/2012

alled dendritic cells, which pick up pathogen parts and must travel from the skin to lymph nodes where immune reactions are initiated.

The Duke team, however, has created a vaccine adjuvant of nanoparticles that are capable of traveling from the point of injection to the lymph nodes where they act on many cell types of the immune system to spur the right reaction for a greatly increased immune response.

The researchers found that they could use this adjuvant in vaccinations of mice with the influenza A virus.

In levels of flu virus exposure that would be lethal in typical mice, the vaccinated mice were able to fight off the disease and had an increased survival rate, thanks to the effective immune response the particles stimulated.

The researchers also showed they could load the same type of particles with a different immune factor, IL-12, that directed a response toward a different set of lymphocytes. This is an important finding since certain types of infections require specialized responses to be overpowered by the body.

St. John said the flexibility of the synthetic particles and their ability to target certain lymph nodes represented a new avenue of personalized medical treatment personalized vaccines.

Senior author Soman Abraham, Ph.D., professor of pathology, immunology and molecular genetics and microbiology at Duke in Durham, N.C., and emerging infectious diseases at Duke-NUS, is cautiously optimistic that the mast-cell-inspired synthetic particles could make their way into human use soon.

"It should not be long because all the individual cytokines (immune system factors) and additional materials loaded into these particles are already FDA approved for use in humans," Abraham said. "There is a lot of interest in nanoparticle-based therapy, but we are basing our materials on our observation of mast cells in nature. This is an informed application to deliver the right material to the right
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BWH researchers develop a vaccine prototype stronger than traditional vaccines
2. 21st century vaccines -- innovation in design and rational use
3. Innovative vaccines with nanotechnology
4. 2020 vision of vaccines for malaria, TB and HIV/AIDS
5. Blame the environment: Why vaccines may be ineffective for some people
6. Cow vaccines go vroom
7. Scientists use computer algorithms to develop seasonal flu vaccines
8. New bacterial signaling molecule could lead to improved vaccines
9. Prescription drug could boost effects of vaccines for HIV and other diseases
10. Vaccines preventing pneumococcal disease protect African children with sickle-cell disease
11. GEN reports on the promise of DNA vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
(Date:3/23/2015)... March 23, 2015  In the 2014 fiscal year, ... conviction losses. This figure accounts for a fraction of ... The Nilson Report, exceeds $11 billion globally. The polygraph ... a crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... Recognizes Leadership in Technology and Innovation in Global ... LMT ) has been named the ... Frost and Sullivan, recognizing the Corporation,s leadership in ... of customers. Frost and Sullivan based the award ...
... The Centre for Genomic Regulation (CRG) in Barcelona, Spain ... by Genomatix Software GmbH. , GGA comprises purpose built ... software providing a complete solution for the analysis of ... genome. "In regards to the machine, I love ...
... 4, 2009 The incidence of pneumothorax (PTX), or collapsed ... has been reported to range from 13 50 percent, ... In people, PTX is reported to be the most preventable ... ultrasound has been infrequently used as a non-invasive, point-of-care imaging ...
Cached Biology News:Lockheed Martin Named Biometrics 'Company of the Year' by Frost and Sullivan 2CRG buys Genomatix' Next Generation Sequencing analysis solution 2Novel veterinary procedure detecting life-threatening injuries touted 2
(Date:3/30/2015)... and BELLINGHAM, Washington, USA (PRWEB) March 29, 2015 ... in Europe and the United States and plenary talks ... planned for SPIE Optics + Optoelectronics next ... over 700 technical presentations in 17 conferences alongside a ... for optics and photonics , the event will run ...
(Date:3/30/2015)... Richmond Pharmacology nimmt weltweit ... ist das erste Zentrum weltweit, das in Zusammenarbeit ... in London in einer ... an einem Patienten begonnen hat. Das Therapeutikum wurde ... (ATTR), einer seltenen Herz- und Nervenkrankheit. ...
(Date:3/29/2015)... IRVING, Texas , March 29, 2015 ... presentation of study data in small cell ... profiling using Caris Molecular Intelligence®, the company,s ... of certain gene mutations which may explain ... Researchers found that identification of certain biomarkers ...
(Date:3/27/2015)... 2015 Earlier this year, the Capillus272Pro™ ... hair regrowth in adult men and women with androgenic ... Hamilton classifications of IIa-V and Fitzpatrick Classification of Skin ... products that over-promise and under-deliver, FDA Clearance underscores the ... confidence among more than 80 million men and women ...
Breaking Biology Technology:Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 2Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 3Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 2Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 3Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2
... BEIJING and CLAREMONT, Calif., Sept. 26 /Xinhua-PRNewswire-FirstCall/,-- ... Board: KWBT),today announced that its wholly owned ... completed the first stage of the planned,upgrading ... and,equipping a fertilizer production line, and installing ...
... Financing To Accelerate Trials and Commercialization, PALO ... Bulletin Board: AVGO), a late-stage biotechnology company that,develops ... that it had conducted an initial closing of ... The Company received gross proceeds of $3,110,000 and ...
... in the Development of Opioid-Based Pain Management Therapy ... Improves Bowel ... / naloxone combination tablet reduces,opioid-induced bowel dysfunction in patients with chronic ... presented,today at the World Institute of Pain (WIP) Congress, Budapest(1). ...
Cached Biology Technology:Kiwa Bio-Tech Completes 1st Stage of Shandong Factory Upgrading 2Avicena Group Announces Closing of Private Offering 2New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain 2New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain 3
Human/Mouse/Rat JNK Pan Specific Affinity Purified PAb...
D-biotin *50 mM aqueous solution* Secondary Detection Biotin–Avidin Detection Reagents Other...
Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1). [Source:Uniprot/SWISSPROT;Acc:P42892] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
X-Gal (5-Bromo-4-Chloro-3-Indoyl-beta -D-Galactopyranoside)...
Biology Products: