Navigation Links
Vaccines for HIV: A new design strategy
Date:2/23/2012

San Diego, Calif. HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate. Physical scientists and clinical virologists from the Massachusetts Institute of Technology (MIT) and the Ragon Institute in Cambridge, Mass., have identified a promising strategy for vaccine design using a mathematical technique that has also been used in problems related to quantum physics, as well as in analyses of stock market price fluctuations and studies of enzyme sequences. The team, led by Arup Chakraborty of MIT and Bruce Walker of the Ragon Institute, will give an update on its work at the Biophysical Society 56th Annual Meeting, held Feb. 25-29 in San Diego, Calif.

Vaccines prime the immune system to target molecular signatures associated with a particular pathogen. But HIV's ability to mutate has made it difficult to identify reliable vaccine targets. In their search for a new type of target, the team from the Ragon Institute did not focus on individual amino acids. Instead, the researchers sought to identify independently evolving groups of amino acids where, within each group, amino acids mutate in tandem (meaning that they rely on one another to maintain the viability of the virus). In particular, they looked for groups of amino acids within which combinations of mutations would have a greater chance of making the virus unviable. By staging a multi-pronged attack against these regions of HIV, the researchers reasoned, they might be able to trap the virus between two bad choices: be destroyed by the immune system, or mutate and destroy itself.

With a mathematical tool called random matrix theory, the team searched for high-order evolutionary constraints in the so-called Gag region of HIV. The researchers were looking for collectively co-evolving groups of amino acids with a high number of negative correlations (meaning multiple mutations would destroy the virus) and a low number of positive correlations (meanin
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. New type of vaccines deliver stronger and faster immune response
2. Vaccines and autism: Many hypotheses, but no correlation
3. New evidence explains poor infant immune response to certain vaccines, says MU researcher
4. Princeton teams analysis of flu virus could lead to better vaccines
5. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
6. Pitt researchers find promising candidate protein for cancer prevention vaccines
7. Bug barcode readers hold out promise of universal vaccines
8. Major breakthrough may pave the way for therapeutic vaccines
9. GEN reports on the promise of DNA vaccines
10. Vaccines preventing pneumococcal disease protect African children with sickle-cell disease
11. Prescription drug could boost effects of vaccines for HIV and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has ... Market 2015-2019" report to their offering. ... trend upcoming in this market is the increasing demand ... in recording of patient data for quick and correct ...
(Date:12/11/2014)... and Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... the addition of the "Biometrics Market in the ... One major trend emerging in this market is ... is important to upgrade biometric solutions to the latest ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... in Nature Cell Biology , scientists from the ... Regenerative Medicine Institute (ARMI) have revealed new insights into ... In an early mammalian embryo, just 8-cells large, the ... something that would determine whether the embryo survived ...
... Colo., USA Locations studied for this month,s posting ... Llaima volcano, Chile; the Mississippi Fan (Gulf of Mexico); ... the Atlas Mountains of Morocco; the East Antarctic Ice ... Regab pockmark, offshore Africa; the Siberian Traps; the eastern ...
... significant signaling network in a tiny organism that,s big ... how a remarkably fast-growing organism conducts its metabolic business ... microbe Synechococcus , which turns sunlight into useful ... Pacific Northwest National Laboratory glimpsed key chemical events, known ...
Cached Biology News:Your first hug: How the early embryo changes shape 2Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 2Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 3Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 4Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 5Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 6Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 7Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 8Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 9Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 10Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 11Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 12Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 13Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 14Offshore pockmarks, Wax Lake Delta, Cabo de Gata, the Siberian Traps: Geology covers the world 15Scientists capture 'redox moments' in living cells 2Scientists capture 'redox moments' in living cells 3
(Date:1/23/2015)... Portal Solutions , a technology consulting ... Microsoft Office 365 and SharePoint platforms , today announces its ... being one of the region’s fastest-growing mid-sized companies based on ... , “To be recognized a second year in a row ...
(Date:1/22/2015)... GEA Niro Soavi the leader in high ... PandaPLUS 2000, which is ideal for new applications for ... disruption . This compact laboratory homogenizer is the perfect ... food additives and ingredients as well as for the ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... 22, 2015 Dr. Greg Leyer of UAS ... Scripps Natural Supplements Pre-Conference seminar on probiotics in San Diego, ... annual continuing education conference for health care professionals. This year’s ... topic of probiotics in health. Dr. Leyer spoke about the ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2
... 2011 Selexis SA , a Swiss-based biotechnology ... high yield and stable mammalian cell-lines for therapeutic protein ... Swiss-based laboratories and staff.  The additional space comes in ... proteins as well as outsourcing support for the rapid ...
... ARNA ) announced today that the company ... Investor Conference on Monday, February 14, 2011, at 9:00 ... in New York City. Jack Lief, Arena,s President and Chief Executive ... live audio webcast of the presentation will be available under the ...
... PARK, N.C., Feb. 8, 2011 Talecris Biotherapeutics Holdings Corp. ... and full year 2010 earnings release after the market closes ... Grifols, S.A., Talecris will not be hosting a conference call ... About Talecris Biotherapeutics: Inspiration. Dedication. ...
Cached Biology Technology:Selexis SA Doubles Cell Line Development Laboratory Space in Geneva, Switzerland 2Arena Pharmaceuticals to Present at the 13th Annual BIO CEO & Investor Conference 2Arena Pharmaceuticals to Present at the 13th Annual BIO CEO & Investor Conference 3
Request Info...
Recombinant Mouse sTNF RII/TNFRSF1B...
One-step, microplate or cuvet, colorimetric, linear detection range 0.2 mg/dL to 20 mg/dL. Procedure: 20 min....
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
Biology Products: