Navigation Links
Vaccines for HIV: A new design strategy
Date:2/23/2012

San Diego, Calif. HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate. Physical scientists and clinical virologists from the Massachusetts Institute of Technology (MIT) and the Ragon Institute in Cambridge, Mass., have identified a promising strategy for vaccine design using a mathematical technique that has also been used in problems related to quantum physics, as well as in analyses of stock market price fluctuations and studies of enzyme sequences. The team, led by Arup Chakraborty of MIT and Bruce Walker of the Ragon Institute, will give an update on its work at the Biophysical Society 56th Annual Meeting, held Feb. 25-29 in San Diego, Calif.

Vaccines prime the immune system to target molecular signatures associated with a particular pathogen. But HIV's ability to mutate has made it difficult to identify reliable vaccine targets. In their search for a new type of target, the team from the Ragon Institute did not focus on individual amino acids. Instead, the researchers sought to identify independently evolving groups of amino acids where, within each group, amino acids mutate in tandem (meaning that they rely on one another to maintain the viability of the virus). In particular, they looked for groups of amino acids within which combinations of mutations would have a greater chance of making the virus unviable. By staging a multi-pronged attack against these regions of HIV, the researchers reasoned, they might be able to trap the virus between two bad choices: be destroyed by the immune system, or mutate and destroy itself.

With a mathematical tool called random matrix theory, the team searched for high-order evolutionary constraints in the so-called Gag region of HIV. The researchers were looking for collectively co-evolving groups of amino acids with a high number of negative correlations (meaning multiple mutations would destroy the virus) and a low number of positive correlations (meanin
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. New type of vaccines deliver stronger and faster immune response
2. Vaccines and autism: Many hypotheses, but no correlation
3. New evidence explains poor infant immune response to certain vaccines, says MU researcher
4. Princeton teams analysis of flu virus could lead to better vaccines
5. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
6. Pitt researchers find promising candidate protein for cancer prevention vaccines
7. Bug barcode readers hold out promise of universal vaccines
8. Major breakthrough may pave the way for therapeutic vaccines
9. GEN reports on the promise of DNA vaccines
10. Vaccines preventing pneumococcal disease protect African children with sickle-cell disease
11. Prescription drug could boost effects of vaccines for HIV and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... The Granite Club, Canada,s ... announced it has implemented a state-of-the-art access and security ... and staff, while restricting access to authorized users only. ... IMID Access system because it has the perfect combination ... in addition to unparalleled security," said James DiRenzo ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... Protection Agency (EPA) has awarded nearly $2.5 million ... eight key environmental areas: monitoring and control of ... hazardous waste monitoring, water infrastructure, homeland security, nanotechnology ... received "proof of concept" awards from EPA, and ...
... -- Tufts University,s School of Arts and Sciences has ... that will house a Collaborative Cluster in Genome Structure ... will bring together experts in such areas as genome ... engineering to focus on "genome to organism" research to ...
... Researchers from Mahidol University have developed a rapid, ... The related report by Munkongdee et al, "Rapid ... the May 2010 issue of The Journal of ... caused by a genetic defect in the production of ...
Cached Biology News:EPA awards small businesses to develop new environmental technologies 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 3
(Date:3/26/2015)... Bruno, CA (PRWEB) March 26, 2015 ... (CRO), announced today several management and executive appointments ... of Chief Financial Officer (CFO) and member of the ... President of Business Operations, and Sue Dowden will assume ... Taricco, co-founder and current Chief Operations Officer (COO), has ...
(Date:3/26/2015)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... matters, including the appointment of auditors, its annual and ... (the "Meeting") was adjourned, as previously disclosed on March ... ( Toronto time). The date of ... disclosed. The Meeting will reconvene at the offices of ...
(Date:3/26/2015)... Louisville, CO (PRWEB) March 26, 2015 ... agency has formed a strategic alliance with Designing Gig ... to their clients. , “Forging this alliance ... company. Now we can extend a comprehensive, end-to-end, ... design, development, strategy, and execution,” said Chuck Miller, president ...
(Date:3/26/2015)... , March 26, 2015  BioNano Genomics, Inc., ... of  Terry Salyer as chief commercial officer. Salyer ... effective, worldwide sales teams in life sciences. At BioNano, ... System, a genome-mapping platform to assemble a comprehensive ... structural variations. To date, 32 institutions located in ...
Breaking Biology Technology:PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3
... , , , EMERYVILLE, ... company, announced today that new research data will be delivered ... on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, CA ... a multi-institutional collaborative in vitro study of Adamas, ...
... , , ... MASI ), the inventor of Pulse CO-Oximetry(TM) and ... its Radical-7 and Rad-57 Pulse CO-Oximeters have achieved Airworthiness ... certification is a fundamental milestone that allows the U.S. ...
... LAUSANNE, Switzerland, September 3 Debiopharm Group, SA,(Debiopharm), ... focus on the development of prescription drugs that ... Sciences Award, to Dr Lluis,Quintana-Murci from the Institut ... the emerging field of evolutionary genetics of,infection. Funded ...
Cached Biology Technology:Adamas Pharmaceuticals to Present Data on Triple Combination Antiviral Drug Therapy for Drug-Resistant Influenza at 2009 ICAAC Annual Meeting 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 4The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 2The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 3
PCR System for increased fidelity, yield and length of PCR products. Amplifies targets up to 10 kb from human genomic DNA....
Request Info...
Immunogen: Heat inactivated bacterial cells of Salmonella enteriditis,paratyphi and typhimurium Storage: 4 C...
US Pharmacopoeia Purified-Water/Water-for-Injection Quality Water...
Biology Products: