Navigation Links
Vaccine targeting latent TB enters clinical testing
Date:12/1/2011

COPENHAGEN, DENMARK/ROCKVILLE, MD, USA Statens Serum Institut and Aeras today announce the initiation of the first Phase I clinical trial of a new candidate TB vaccine designed to protect people latently infected with TB from developing active TB disease. The trial is being conducted by the South African Tuberculosis Vaccine Initiative (SATVI) at its field site in Worcester, in the Western Cape province of South Africa. Dr. Hassan Mahomed is the principal investigator.

"Two billion men, women and children live with latent TB infection," said Jim Connolly, President and Chief Executive Officer of Aeras. "It's daunting to comprehend that there is a vast reservoir of people with a 5-10% lifetime risk of becoming sick with TB. A vaccine that prevents TB disease in this population could save millions of lives, and this trial is a first step in assessing a vaccine candidate designed for this purpose."

The candidate TB vaccine (SSI H56-IC31) is a subunit vaccine containing recombinant TB proteins formulated in a proprietary adjuvant IC31 from Intercell. It is being developed under a consortium of researchers led by Peter Andersen at the Statens Serum Institut (SSI) based in Copenhagen. The consortium is supported as part of the Grand Challenges in Global Health, an initiative that fosters scientific breakthroughs needed to prevent, treat and cure diseases of the developing world.

"The development of urgently needed new TB vaccines requires a global effort," said Prof. Peter Andersen, the Vice President of Vaccine Research & Development at SSI. "The advancement of this candidate from an idea to the clinic working in collaboration first with the Grand Challenges consortium and now with Aeras and SATVI is an important and exciting milestone for all the researchers involved."

This clinical trial will be the first to test this vaccine candidate in people. It will assess the safety and immunogenicity of SSI H56-IC31 in 25 adults, including participants with and without latent TB infection. SSI H56-IC31 has been tested in several pre-clinical studies with no safety concerns and has shown efficacy in small animal models administered both before infection and to latently infected animals. The vaccine was also shown to control clinical disease and reactivation in a non-human primate model. This is the first time a South African research institute has led a first-in-human Phase I clinical trial of a new TB vaccine.

"SATVI is delighted to be part of the trial at this early stage, which is testament to the high-regard that the developers have for our TB vaccine clinical research expertise to conduct these crucial early trials in humans," said SATVI Director, Professor Willem Hanekom.

SSI H56-IC31 is being developed for both adolescent and adult populations. The trial has been approved by the Medicines Control Council of South Africa. Preliminary results of this trial are expected at the end of 2012.


'/>"/>
Contact: Annmarie Leadman
aleadman@aeras.org
240-599-3018
Aeras
Source:Eurekalert

Related biology news :

1. BWH researchers develop a vaccine prototype stronger than traditional vaccines
2. Award-winning research points toward Alzheimer’s vaccine
3. 21st century vaccines -- innovation in design and rational use
4. Newly identified antibodies may improve pneumonia vaccine design
5. TB vaccine candidate shows early promise
6. Scripps Research scientists create vaccine against heroin high
7. Promising developments in vaccine research, development of a vaginal gel and PrEP lead to calls for a combination of biomedical and non biomedical approaches to HIV prevention policy
8. Discovery of natural antibody brings a universal flu vaccine a step closer
9. Innovative vaccines with nanotechnology
10. Adjuvant combo shows potential for universal influenza vaccine
11. Study shows the HPV vaccine Gardasil doesnt increase disease activity in SLE patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)... 4, 2017  CES 2017 – Valencell , ... today announced the launch of two new versions ... highly-accurate biometric sensor modules that incorporate the best ... and expertise. The two new designs include Benchmark ... hearables, and Benchmark BW2.0, a 2-LED version of ...
(Date:12/22/2016)... Dec. 20, 2016  As part of its longstanding mission ... personal genetics company, recently released its latest children,s book, titled ... book focuses on the topics of inheritance and variation of ... (NGSS) taught in elementary school classrooms in the US. ... by illustrator Ariana Killoran , whose previous book with ...
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Calif. , Jan. 17, 2017  Protagonist ... announced that it has initiated a global Phase ... an oral peptide that targets alpha4beta7 integrin. The ... study is to evaluate the safety/tolerability and efficacy ... patients with moderate to severe active disease. ...
(Date:1/16/2017)... Morrisville, NC (PRWEB) , ... January 16, 2017 ... ... science company, received the prestigious Tibbetts Award from the U.S. Small Business ... participants “that have created a significant economic or social impact […] and are considered ...
(Date:1/13/2017)... DUBLIN , Jan 13, 2017 Research ... by Product, Manufacturing, Application - Global Forecast to 2021" report ... ... by 2021 from USD 3.39 Billion in 2016, at a CAGR ... on the basis of product, manufacturing type, and application. Factors such ...
(Date:1/13/2017)... Island, NY (PRWEB) , ... January 13, 2017 ... ... teamed up with several companies to offer its customers three new solutions for ... probe would come in handy if a customer has an oddly-shaped sample that ...
Breaking Biology Technology: