Navigation Links
Vaccine made with synthetic gene protects against deadly pneumonia
Date:2/21/2011

on knocking out genes, which eliminates their expression completely."

Altering the pneumolysin gene in the seroptype 3 bacteria resulted in less pneumolysin toxin produced in vitro. When mice were injected with either attenuated or unattenuated serotype 3 bacteria, mice receiving the attenuated strain developed an inflammatory response much weaker than was observed in mice receiving the unattenuated serotype 3 strain. Most important, of the five mice injected with the attenuated strain, four survived a subsequent challenge from the highly virulent unattenuated serotype 3 strain, which was lethal in five of five unvaccinated, control mice.

This method of reducing gene expression had been used for viral pathogens, but this is the first time that gene customization has successfully controlled virulence in bacteria. The study's findings could potentially lead to pneumococcal vaccines based on weakened strains, and the Einstein researchers are now investigating whether they can reduce the expression of other genes associated with pneumococcal virulence.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Media advisory -- Partnering to Fight TB: The Role of a TB Vaccine PDP
2. Saint Louis University findings: Dont pitch stockpiled avian flu vaccine
3. Researchers test inhalable measles vaccine
4. Therapeutic AIDS vaccine designed by HIVACAT reduces the viral load in the majority of AIDS patients
5. H1N1 pandemic points to vaccine strategy for multiple flu strains
6. Team creates novel vaccine that produces strong immunity against cocaine high
7. New vaccine to assist worldwide eradication of polio
8. Experts converge at Arizona State University for first preventive cancer vaccine conference
9. Blame the environment: Why vaccines may be ineffective for some people
10. New needle-free HPV vaccine increases effectiveness, availability in developing world
11. New low-cost method to deliver vaccine shows promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and ... the addition of the "iPhone 5S Fingerprint ... Report" report to their offering. ... the acquisition of AuthenTec in July 2012, Apple ... 5S. It is currently the only device of ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated ... to 2019. Although the U.S. market holds a larger ... is expected to grow at a higher CAGR of ...
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, ... publication of a study that pinpoints fine-scale differences in ... United States . Since immigrants first ... the United States has served as a ... illuminates how American history and the ongoing mixing of ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... around the world are faced with two daunting tasks—maintaining ... as possible. In the years following the terrorist attacks ... in the U.S. but around the world. Most officials ... concern, yet many security measures end up detaining passengers, ...
... centers of men and women,s brains works is different, ... journal Biology of Sex Differences . Men have ... but women are better at discriminating between colors. ... sex hormone (androgen) receptors throughout cerebral cortex, especially in ...
... 1. No Nutritional or Safety Differences Between Organic and ... in nutritional value or risk for bacterial contamination between ... being published in Annals of Internal Medicine , ... (ACP). While the consumption of organic fruits and vegetables ...
Cached Biology News:Securiport: Biometric Scanning is Gold Standard in Airport Security 2The eyes have it: Men do see things differently to women 2Annals of Internal Medicine tip sheet for Sept. 4, 2012 2Annals of Internal Medicine tip sheet for Sept. 4, 2012 3Annals of Internal Medicine tip sheet for Sept. 4, 2012 4
(Date:12/19/2014)... 18, 2014 Ed Bilsky, Ph.D., vice ... Center for Excellence in the Neurosciences (CEN), and professor ... been selected as a member of the prestigious Dana ... neuroscientist from Maine to receive this honor. , ... entirely by the Dana Foundation. Its mission is ...
(Date:12/19/2014)... The empty capsules market is experiencing growth ... technological innovations in the empty capsules market. The ... growth of the empty capsules market. , Get ... of Report , The report will enrich both ... to gauge the pulse of the market which ...
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
(Date:12/17/2014)... 16, 2014 “Never say, ‘I ... Universität Marburg’s Department of Physics, advises young women ... newly released SPIE Women in Optics 18-month ... shy to ask questions.” , In the annual ... mathematics) occupations ranging from university professor and laboratory ...
Breaking Biology Technology:UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... , July 8 Calithera ... the completion of a Series A financing totaling ... U.S. Venture Partners, Advanced Technology Ventures, Delphi Ventures and ... capital will be used to support the company,s pioneering ...
... VANCOUVER , July 7 /PRNewswire-FirstCall/ - Dragon Pharmaceutical ... that based on the receipt of preliminary proxies, the Company ... and Plan of Merger ("Merger") by and among Dragon, Chief ... Limited, and Mr. Yanlin Han . The Merger must ...
... , , ... replacement for petroleum oil more than doubles rubber,s stretchability and reduces its environmental impact ... Ford,s biomaterial researchers are ... as deflector shields and baffles, radiator deflector shields, cupholder inserts and floor mats , ...
Cached Biology Technology:Calithera Biosciences Closes $40 Million in Series A Financing 2Calithera Biosciences Closes $40 Million in Series A Financing 3Calithera Biosciences Closes $40 Million in Series A Financing 4Dragon Pharma announces receipt of preliminary proxies to approve merger 2Dragon Pharma announces receipt of preliminary proxies to approve merger 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 2Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 4
... Genomics Solution is a comprehensive suite ... visualization specifically designed to reliably extract ... high-dimensional genomic studies containing thousands of ... memory efficient and will analyze large ...
...
...
Hepatocyte Differentiation Environment...
Biology Products: