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Vaccine for Ebola virus
Date:3/30/2008

se viruses we need to get a cell-mediated response, which involves our bodies producing killer T-cells before immunity is strong enough to prevent or clear an infection.

The researchers have now used several different recombinant DNA techniques, which have allowed them to trigger a cell-mediated response and produce a vaccine that is effective in non-human primates. One of the candidate vaccines is about to be tested on people for the first time, after entering Phase 1 clinical trials in autumn 2006.

Ebola virus infection of humans can be highly lethal but monkeys rarely survive the infection and have been very useful as animal models. Ebola vaccine trials using nonhuman primates have provided unambiguous results and have allowed the development of protective vaccines to progress rapidly, says Dr Sanchez. Successful human trials will mean that we can vaccinate healthcare workers and other key personnel during outbreaks of Ebola haemorrhagic fever, helping us to protect their lives and control the spread of the disease.

The US team hopes that the findings from their studies will provide important insights that will improve or accelerate the future development of vaccines for other haemorrhagic fever viruses like Marburg virus, and agents such as HIV and avian influenza.


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Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

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