Navigation Links
Vaccine could delay bowel inflammation and colon cancer, says Pitt research
Date:3/24/2010

PITTSBURGH, March 24 An experimental vaccine against an abnormal protein found in some tumors has the potential to delay the onset of inflammatory bowel disease (IBD) and in turn prevent progression to colon cancer, according to researchers at the University of Pittsburgh School of Medicine. Their findings are reported this week in Cancer Prevention Research, a journal of the American Association for Cancer Research.

People with chronic inflammatory disorders such as IBD are at greater risk for developing cancer at the inflamed site, said senior author Olivera Finn, Ph.D., professor and chair, Department of Immunology, Pitt School of Medicine. In other cases, genes that develop cancerous changes can trigger inflammation. The vaccine made by her team is directed against an abnormal variant of a self-made cell protein called MUC1, which is altered and produced in excess in both IBD and colon cancer.

"Our experiments indicate that boosting the immune response against this protein early in the disease can delay IBD development, control inflammation and thereby reduce the risk of future cancers," Dr. Finn said. "These findings suggest also that the early stages of chronic inflammation might be considered a premalignant condition."

The researchers tested transgenic mice that spontaneously develop IBD and then progress to colitis-associated colon cancer, producing the human version of MUC1 in both disease states. They found that animals that received the vaccine showed the first signs of IBD significantly later than those in two control groups that did not get the vaccine.

Microscopic evaluation of the colon tissue showed less inflammation in the vaccinated mice, and no indication of cancerous changes. Nearly half of the animals in each of the control groups had evidence of abnormal tissue, and two had colon cancer.

"The MUC1 vaccine seems to change the local environment from one that promotes cancer development t
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Possible hepatitis C vaccine
2. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
3. New nanoparticle vaccine is more effective but less expensive
4. Flu vaccine in painless skin patches under development at Emory, Georgia Tech with NIH grants
5. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
6. An Alzheimers vaccine?
7. Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine
8. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
9. HIV isolate from Kenya provides clues for vaccine design
10. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
11. Vaccine for Ebola virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... Nature Climate Change , suggests that if current trends ... the global targets for total greenhouse gas (GHG) emissions in ... think carefully about the food we choose and its environmental ... just one of a number of actions that need to ... is enough food for all. , As populations rise ...
(Date:8/31/2014)... French . ... the prestigious Nature Neuroscience journal by, Sylvain Williams, ... Douglas Mental Health University Institute and McGill University, opens the ... mechanisms controlling memory as well of the role of an ... subiculum. , In 2009, they developed a unique approach ...
(Date:8/29/2014)... SAN ANTONIO (Aug. 29, 2014) Scientists at the ... the School of Medicine at the UT Health Science ... longevity in the tissues of the longest-lived rodent, the ... factor in the cells of naked mole rats protects ... disposer for damaged and obsolete proteins. , The factor ...
Breaking Biology News(10 mins):Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2Factor in naked mole rat's cells enhances protein integrity 2
... agricultural ecosystems near Montreal, a new tool that ... wide range of ecological services has been developed ... Geography, Elena Bennett of the McGill School of ... Centre at Stockholm University. Environmental management typically focuses ...
... is available in German . Halle ... around 115,000 years ago, there were significant climate fluctuations. ... the Eemian Interglacial to the Weichselian Glacial was marked ... at least two warming events. This is the finding ...
... The 2010 American Society for Microbiology (ASM) ... presented to John J. Tudor, Ph.D., St. Joseph,s ... years of teaching. This award recognizes an educator ... Tudor received his Ph.D. from the University ...
Cached Biology News:Seeing the hidden services of nature 2Were short warm periods typical for transitions between interglacial and glacial epochs? 2American Society for Microbiology honors John J. Tudor 2
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... Pittcon is pleased to announce that the ... Horiba Scientific, have organized a session on nanotechnology for ... , Asia’s largest analytical and scientific instruments show, will ... , The four speakers in this U.S. symposium, ... to Single Cells” will present their use of nanotechnology ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Livermore Team Awarded for Hydrogen Production Research 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... journal BioMedical Engineering OnLine refutes claims that portable music ... , Howard Bassen, a researcher with the U.S. Food ... team that measured the magnetic fields produced by four ... iPod with video, and an iPod nano and iPod ...
... Medical,Innovations, Inc. (Amex: IMA ), a leading ... consumer and professional markets, announced,today that it will ... and Medical Device Conference being held,February 5 through ... New York City. Ron,Zwanziger, Chief Executive Officer, and ...
... Promotions Support Fund,s Goal of Finding a Cure ... Pfizer Animal Health and the National,Thoroughbred Racing Association ... through the NTRA Charities - Barbaro Memorial Fund. ... Fund across the horse,industry and encourage further support ...
Cached Biology Technology:New research shows that iPods do not interfere with cardiac pacemakers 2Inverness Medical Innovations to Participate at 2008 Merrill Lynch Global Pharmaceutical, Biotechnology and Medical Device Conference on February 5, 2008 2Pfizer Animal Health and NTRA Charities Team Up to Benefit the Barbaro Memorial Fund 2
... range of next-generation features into a small-footprint ... for flexible laboratory solutions. It puts every ... dilution, dispensing, and integrations into a ... flexible as it is efficient and economical. ...
... mini incubation trays are disposable ... screen antigens that have been ... tray has eight 10.5 cm ... accommodate strips cut from blotted ...
... The GenomeLab GeXP Genetic Analysis System ... scalable, multiplexed PCR*. The systems patented ... standard multiplexed PCR analysis to just a ... GeXP delivers more genes per reaction and ...
... Chemicon Detergent-OUT SDS Kit is a simple ... protein solutions. Removes detergents without significant ... the protein solution on the Detergent-OUT Spin ... Med columns are suitable for removing ...
Biology Products: