Navigation Links
VTT identified specific bacteria which precede autoimmune diabetes
Date:10/28/2011

A study led by Matej Oreič from VTT Technical Research Centre of Finland suggests that autoimmune diabetes is preceded by diminished gut microbial diversity of the Clostridium leptum subgroup, elevated plasma leptin and enhanced glucose-stimulated insulin secretion.

In collaboration with the DIPP - Finnish Type 1 Diabetes and Prediction study, VTT researches have previously found that specific metabolic disturbances precede early β-cell autoimmunity markers in children who subsequently progress to type 1 diabetes. However, the question remained what are the environmental causes and tissue-specific mechanisms leading to these disturbances?

Matej Oreič from VTT Technical Research Centre of Finland and collaborators Eriika Savontaus from the University of Turku, Samuel Kaski from Aalto University and Mikael Knip from the University of Helsinki set out to address this question, and the results were published on October 27, 2011 in PLoS Computational Biology journal.

The team carried out a study using non-obese diabetic (NOD) mice that recapitulated the protocol used in the DIPP clinical study, followed up by independent studies in which NOD mice were studied in relation to the risk of diabetes progression. Researchers found that young female NOD mice that later progress to autoimmune diabetes exhibit the same metabolic pattern as prediabetic children. These metabolic changes are accompanied by enhanced glucose-stimulated insulin secretion, upregulation of insulinotropic amino acids in islets, elevated plasma leptin and adiponectin, and diminished gut microbial diversity of the Clostridium leptum subgroup.

The elucidation of early metabolic pathways associated with progression to Type 1 diabetes points to novel avenues for early disease prevention. The ongoing efforts of VTT researchers are focused on the potential of specific bacteria from the C. leptum subgroup to help prevent Type 1 diabetes.

This study was supported by the Finnish Funding Agency for Technology and Innovation Tekes, the Seventh Framework Program of the European Community, and Juvenile Diabetes Research Foundation.

The environmental factors and molecular mechanisms leading to Type 1 diabetes are poorly understood and of great public health interest. The incidence of inflammatory and autoimmune diseases is rising faster than for any other major disease, and these diseases are affecting a wide spectrum of the population. The number of new cases of Type 1 diabetes in European children less than 5 years of age is expected to double between 2005 and 2020.


'/>"/>
Contact: Matej Oresic
matej.oresic@vtt.fi
358-207-224-491
VTT Technical Research Centre of Finland
Source:Eurekalert

Related biology news :

1. Stem rust-resistant wheat landraces identified
2. Autistic facial characteristics identified
3. Genome-wide studies have identified new genes involved in susceptibility to melanoma
4. Tick responsible for equine piroplasmosis outbreak identified
5. Newly identified DNA repair defect linked to increased risk of leukemia relapse
6. Limits for mountain trail use identified
7. Cellular origin of a rare form of breast cancer identified
8. Newly identified antibodies may improve pneumonia vaccine design
9. A novel mechanism that regulates pro-inflammatory cells is identified
10. New genes for risk and progression of rare brain disease identified
11. Sardines and horse mackerel identified using forensic techniques
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the medical ... premium product recently added to the range of products distributed by Ampronix. ... ... ... Ampronix News ...
(Date:5/9/2016)... Elevay is currently known as ... for high net worth professionals seeking travel for work ... world, there is still no substitute for a face-to-face ... your deal with a firm handshake. This is why ... of citizenship via investment programs like those offered by ...
(Date:4/26/2016)... LONDON , April 26, 2016 /PRNewswire/ ... Systems, a product subsidiary of Infosys (NYSE: ... partnership to integrate the Onegini mobile security platform ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration ... security to access and transact across channels. Using ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Global demand for enzymes is forecast to grow ... billion.  This market includes enzymes used in industrial ... animal feed, and other markets) and specialty applications ... beverages will remain the largest market for enzymes, ... containing enzymes in developing regions.  These and other ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... medical technologies, services and solutions to the healthcare market. The company's primary focus ... distribution, manufacturing, sales and marketing strategies that are necessary to help companies efficiently ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
Breaking Biology Technology: