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VEGF Inhibition: Therapy-Indicating and Prognostic Biomarkers, 2013
Date:2/5/2013

ensive review of clinical studies that have identified biomarkers that are either therapy-indicating in respect of bevacizumab (Avastin®) or indicative of patient prognosis

• Biomarkers identified or further evaluated in the last five years, up until January 2013. From a background of extensive research on bevacizumab (Avastin®) and VEGF-related biomarkers, the most important findings have been identified for their significance and value to patients and in designing clinical trials

• Covering more than ten cancers including colorectal, ovarian, renal, breast, pancreatic, prostate, lung and liver cancers

• Findings based on clinical trial findings including patient numbers, statistics and RECIST criteria

• Studies indicate drug type associations together with comparative therapies

• Descriptions and explanation of all biomarkers identified (proteins, genotypes, imaging etc)

• Biomarker associations are categorised according to three broad criteria, namely "positive-therapy-indicating" (response, improved response, improved outcome or prognosis), "non-therapy-indicating" (no differences in tumour response, outcome or prognosis) and "negative-therapy-indicating" (adverse events, poor outcome or prognosis).

 

 

 

Executive Summary

 

Chapter 1: Background (p.18)

 

1.1 VEGF Inhibition

1.2 Bevacizumab

1.3 Biomarkers

1.4 This Report

 

Chapter 2 Colorectal Cancer: Candidate Biomarkers identified in Patients receiving Bevacizumab-containing Therapies (p. 22)

 

Summary

2.1 Introduction

2.2 Glycoprotein

2.3 Protein

2.4 Protein

2.5 Cells

2.6 Genetic

2.7 Physical

2.8 Genetic

2.9 Protein

2.10 Proteins

2.11 Proteins and Genetic

2.12 Image

2.13 Proteins

2.14 Pro
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