• Biomarkers identified or further evaluated in the last five years, up until January 2013. From a background of extensive research on bevacizumab (Avastin®) and VEGF-related biomarkers, the most important findings have been identified for their significance and value to patients and in designing clinical trials
• Covering more than ten cancers including colorectal, ovarian, renal, breast, pancreatic, prostate, lung and liver cancers
• Findings based on clinical trial findings including patient numbers, statistics and RECIST criteria
• Studies indicate drug type associations together with comparative therapies
• Descriptions and explanation of all biomarkers identified (proteins, genotypes, imaging etc)
• Biomarker associations are categorised according to three broad criteria, namely "positive-therapy-indicating" (response, improved response, improved outcome or prognosis), "non-therapy-indicating" (no differences in tumour response, outcome or prognosis) and "negative-therapy-indicating" (adverse events, poor outcome or prognosis).
Chapter 1: Background (p.18)
1.1 VEGF Inhibition
1.4 This Report
Chapter 2 Colorectal Cancer: Candidate Biomarkers identified in Patients receiving Bevacizumab-containing Therapies (p. 22)
2.11 Proteins and Genetic
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