Navigation Links
VCU receives NIH grant to examine the biology of allergic disease
Date:7/17/2013

The National Institutes of Health has awarded Virginia Commonwealth University a grant totaling $1.8 million to study the biology of allergic disease work which may one day point researchers to the development of therapies to fight asthma, allergy and inflammatory conditions such as rheumatoid arthritis, multiple sclerosis and heart disease.

The five-year grant will be led by John Ryan, Ph.D., associate professor in the Department of Biology in the VCU College of Humanities and Sciences. Ryan and his colleagues will investigate how interleukin-10, IL-10, controls mast cell homeostasis.

IL-10 is a type of signaling protein known for its anti-inflammatory effects. Mast cells, which are known to play a central role in asthma and allergy, are packed with granules containing histamine and are found in nearly all tissues, with the exception of blood. Inflammatory substances such as histamine, heparin and a number of cytokines are rapidly released into tissues and blood when a mast cell is activated. This results in an allergic response.

"This project is helping us understand how mast cells, the causative agent of allergic disease and asthma, are naturally regulated," said Ryan.

"Our data suggest that factors produced by other white blood cells, especially the cytokine IL-10, function as feedback regulators to prevent mast cell-mediated inflammation from becoming chronic. We have recently found that genetic background can alter responsiveness to this feedback regulation, which could predispose individuals to chronic allergic diseases like asthma."

Earlier this year, Ryan received a $1.8 million NIH National Institute of Allergy and Infectious Diseases grant for another project investigating the molecular interaction of two enzymes and their involvement in inflammation. This project is designed to understand how the production of autoantibodies leads to arthritis.

"We are specifically interested in how two enzymes, tyrosine kinases called Fyn and Lyn, appear to be activated inside immune cells," Ryan said. "We believe that these two enzymes are an antagonistic pair, with Fyn promoting and Lyn antagonizing the onset of arthritis."

Understanding this pathway could lead to the design of new therapies for rheumatoid arthritis, he said. The project is also five years.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-828-1231
Virginia Commonwealth University
Source:Eurekalert

Related biology news :

1. Carnegies Chris Field receives Max Planck Research Prize
2. Penn receives prestigious national award for breakthrough in gene therapy
3. Peihua Jiang receives Ajinomoto Award for Young Investigators in Gustation from AChemS
4. Forsyth Institute receives $4.1 million grant for new center
5. Einstein receives $12 million grant to develop device for preventing HIV infection
6. Wayne State vision restoration technology receives Notice of Allowance for US patent app
7. BU researcher receives highest honor from the National Birth Defects Prevention Network
8. Geneticist Svante Pääbo receives the $500,000 Gruber Genetics Prize
9. Artificial retina receives FDA approval
10. NTU Provost receives prestigious Imperial College fellowship joining the ranks of top UK scientists
11. Xenon Receives a Milestone Payment for Marketing Approval of Glybera in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use fingerprints instead ... National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in ... the boarding process to allow eligible Delta SkyMiles Members who are enrolled ...
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/7/2017)... WALTHAM, Mass. , Oct. 6, 2017 /PRNewswire/ ... pioneering work of three scientists, Jacques Dubochet, ... whose breakthrough developments in cryo-electron microscopy ... this technology within the structural biology community. The ... Scientific. Scientists can now routinely produce highly resolved, ...
Breaking Biology Technology: