Navigation Links
VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
Date:12/3/2010

Richmond, Va. (Dec. 3, 2010) Research at Virginia Commonwealth University Massey Cancer Center led by Charles E. Chalfant, Ph.D., associate professor of biochemistry and molecular Biology, discovered a previously unknown mechanism in non-small cell lung cancer (NSCLC) cells that contributes to their ability to maintain and grow tumors. Narrowing in on this mechanism could provide a breakthrough for the development of effective therapies for NSCLC and other cancers.

The findings, recently published in Journal of Clinical Investigation, provide the first example of a protein factor regulating the expression of the protein caspase-9, a main player in apoptosis, or programmed cell death. Scientists have known that healthy cells favor caspase-9a, a form of the caspase-9 protein that promotes natural apoptosis. What Chalfant and his research team found is that NSCLC cells favor caspase-9b, which is the anti-apoptotic form of caspase-9 that promotes tumor formation, growth and maintenance. Their further investigation discovered that a protein known as hnRNP L functions as an RNA splicing factor by promoting the expression of caspase-9b through a process known as RNA splicing. While hnRNP L was previously known to have a role in protein expression, its function in relation to cancer biology was unclear until Chalfant's study.

"We're researching an unexplored area of RNA splicing factors in relation to cancer," says Chalfant. "Before this study, there had been very little evidence of an RNA splicing event that results in cancerous tumor development. This study points to caspase-9b as being a very important target in the development of a durable therapy for non-small cell lung cancer."

In mouse models, the researchers used a virus-based targeted gene therapy to reduce the amount of hnRNP L in NSCLC cells. They then observed a lower ratio of caspase-9b to caspase-9a. The result completely stopped the growth of the tumors and had no
'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Knowledge of genetic cancer risks often dies with patients, finds VCU Massey Cancer Center
2. Chemical equator discovery will aid pollution mapping
3. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
4. Groundbreaking discovery may lead to stronger antibiotics
5. Discovery of natural compounds that could slow blood vessel growth
6. Nanoscopic screening process to speed drug discovery
7. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
8. New $11 million center to speed production of new compounds for drug discovery
9. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
10. New discovery may enhance MRI scans, lead to portable MRI machines
11. Kidney function discovery sheds light on genetic complexity of disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
(Date:5/21/2015)... According to a new ... Software, Services), by Applications (Surveillance (Airborne, Maritime, Land), ... (Military & Defense & Commercial) - Global Forecast ... is expected to grow from $7252.0 Million in ... Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/19/2015)... May 19, 2015  Technology is rapidly advancing, outpacing ... in the cloud. Passwords and their management are soon ... and standards-based specifications such as those developed by the ... of passwords presents for BYOD, COPE, IoT, and mobile ... identity protocol. In response to the ...
(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... 2011 AVT, Inc., (formerly Automated Vending Technologies) ... the vending and automated retailing industries by offering ... directly to consumers, 24-hours a day, without the ... This breakthrough system uses advanced biometric fingerprint ...
... brain play a role as an electric wire conveying ... with various joints (synapse), various brain functions can occur. ... the signals with many synapses located on those dendritic ... signals. The research team of Associate Professor Kubota from ...
... abnormalities found in the brains of veterans with Gulf War ... some cases have gotten worse, according to a new study ... confirmed that abnormal blood flow continued or worsened over the ... damage is ongoing and lasts long term," said principal investigator ...
Cached Biology News:A 3-D reconstructed image of neural dendritic trees using the advanced electron microscope technology 2Study finds chronic abnormal brain blood flow in Gulf War veterans 2
(Date:5/21/2015)... (PRWEB) May 21, 2015 Patent Offering, ... method for diagnostic or therapeutic imaging within a body ... uses an endoscope having a low cost, single-use disposable ... filing date was October 18, 2013 and the patent ... technology enables the physician to customize the lighting and ...
(Date:5/21/2015)... Ontario (PRWEB) May 21, 2015 ... into an exclusive North American distribution agreement with ... testing system. , With more than 160 years ... products and services for laboratory and production facilities, ... operational excellence and differentiated services to enable science. ...
(Date:5/20/2015)... DUBLIN , May 19, 2015 Research and ... addition of the "Global Cell Therapy Market Outlook ... Utilization of cell therapy in tissue and regenerative medicine ... are no other options which could help in the ... in this segment but they are unable to form ...
(Date:5/20/2015)... , May 20, 2015  Marc Tessier-Lavigne, president ... gift of $100 million from The Marie-Josée and ... new laboratory building that will be the centerpiece ... Marie-Josée and Henry R. Kravis Research Building, two ... Drive, spanning approximately three city blocks following the ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4
... for Thursday, May 1, 2003 at the Midwest Express ... addressing the commonchallenges of migrating Microsoft Windows NT(R) 4.0 ... family delivers a connected, scalable,reliable platform that has been ... complex IT infrastructure problems. , , ,"We are ...
... share of common stock of Bruker AXS will be converted ... stock of Bruker Daltonics or, at the election of each ... payable 75% in Bruker Daltonics common stock and 25% in ... not being changed in the merger. , ,The combined company, ...
... It's no news that broadband access is on the rise ... least, the arrival of broadband is followed rather quickly by ... venture to say that consumers and consumer applications are now ... WiFi, wired home networking had been the stuff of nerdy ...
Cached Biology Technology:Bruker Daltonics and Bruker AXS Announce Merger Agreement 2Is it Mobile if it's Wireless at Home? 2
... The Mini-PROTEAN II multiscreen apparatus is used ... 7 cm) gels. The apparatus can screen up ... to cut the blot into strips. The apparatus ... templates that accommodate one or two 8 x ...
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
... II Informatix dimensioning ... optional module that ... analysis, multidimensional scaling, ... MANOVA, and self-organizing ...
Fingerprinting II comparative quantification and polymorphism analysis is an optional module that adds comparative quantification and polymorphism analysis functions to the Fingerprinting II Basic so...
Biology Products: