Navigation Links
VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
Date:12/3/2010

Richmond, Va. (Dec. 3, 2010) Research at Virginia Commonwealth University Massey Cancer Center led by Charles E. Chalfant, Ph.D., associate professor of biochemistry and molecular Biology, discovered a previously unknown mechanism in non-small cell lung cancer (NSCLC) cells that contributes to their ability to maintain and grow tumors. Narrowing in on this mechanism could provide a breakthrough for the development of effective therapies for NSCLC and other cancers.

The findings, recently published in Journal of Clinical Investigation, provide the first example of a protein factor regulating the expression of the protein caspase-9, a main player in apoptosis, or programmed cell death. Scientists have known that healthy cells favor caspase-9a, a form of the caspase-9 protein that promotes natural apoptosis. What Chalfant and his research team found is that NSCLC cells favor caspase-9b, which is the anti-apoptotic form of caspase-9 that promotes tumor formation, growth and maintenance. Their further investigation discovered that a protein known as hnRNP L functions as an RNA splicing factor by promoting the expression of caspase-9b through a process known as RNA splicing. While hnRNP L was previously known to have a role in protein expression, its function in relation to cancer biology was unclear until Chalfant's study.

"We're researching an unexplored area of RNA splicing factors in relation to cancer," says Chalfant. "Before this study, there had been very little evidence of an RNA splicing event that results in cancerous tumor development. This study points to caspase-9b as being a very important target in the development of a durable therapy for non-small cell lung cancer."

In mouse models, the researchers used a virus-based targeted gene therapy to reduce the amount of hnRNP L in NSCLC cells. They then observed a lower ratio of caspase-9b to caspase-9a. The result completely stopped the growth of the tumors and had no
'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Knowledge of genetic cancer risks often dies with patients, finds VCU Massey Cancer Center
2. Chemical equator discovery will aid pollution mapping
3. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
4. Groundbreaking discovery may lead to stronger antibiotics
5. Discovery of natural compounds that could slow blood vessel growth
6. Nanoscopic screening process to speed drug discovery
7. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
8. New $11 million center to speed production of new compounds for drug discovery
9. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
10. New discovery may enhance MRI scans, lead to portable MRI machines
11. Kidney function discovery sheds light on genetic complexity of disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
(Date:4/22/2014)... presented Beaumont Health System with prestigious, competitive research ... athletic and nonathletic injuries. , The American ... grant to fund stem cell-based research that could ... ruptured knee anterior cruciate ligament, or ACL. According ... cruciate ligament injury is the over-stretching or tearing ...
(Date:4/22/2014)... at the University of Kentucky has discovered new methods ... , The research, led by Peixuan Guo, professor ... the UK College of Pharmacy and Markey Cancer Center, ... Boiling-Resistant Anionic Polymer Material To Build Robust Structures with ... and Daniel L. Jasinski. , The article, which will ...
Breaking Biology News(10 mins):Beaumont awarded grants to study sports-related injury treatment, improve recovery 2RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2
... has discovered the first identified droplets of spider blood in ... , Two droplets of blood, technically known as haemolymph, have ... - Filistatidae - a family commonly found in South America ... examples of spider blood ever found in an amber fossil. ...
... painkiller prompts brain to release endorphins, bringing real relief ... medicine will relieve pain is enough to prompt the ... painful sensations, a new University of Michigan study finds. ... the brain's own pain-fighting chemicals, called endorphins, play a ...
... completed 60 days of voluntary bedrest in order to ... body. The research team in Toulouse, France, is now ... continue and enhance the research. , At the beginning ... of the WISE study (Women International Simulation Experiment), were ...
Cached Biology News:Spider blood found in 20 million year old fossil 2Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect' 2Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect' 3Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect' 4Female volunteers prepare for a second 'bedrest' 2
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
(Date:1/14/2014)... 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology ... therapies addressing major unmet medical needs using RNA-targeted ... of Allowance from the United States Patent and ... (sd-rxRNA®), for the treatment of fibrosis. The patent ...
(Date:1/14/2014)... 13, 2014 Bob Hainsey, a semiconductor ... 20 years in the industry, has joined SPIE, ... will serve as the society’s Science and Technology Strategist. ... SPIE as our Technology Strategist, further strengthening the technical ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... has launched PATHT HTS, a new platform for high-throughput ... the microarray industry's annual conference, Chips To Hits in ... the performance of PATH protein microarray slides," said Robert ... BioSurfaces. "PATH HTS was designed to meet the ...
... The NeuronFarm, a developer of Web-based applications intended ... immediate availability of its flagship product, 3D-Readers. , ... third through eighth graders in several school studies, ... automated text scoring, engaging simulations and immediate feedback ...
... As more organizations look at what needs to be ... an area that has come under the spotlight is ... corporate governance issues have become issues even within the ... Act (SOX) has become a reason to organize and ...
Cached Biology Technology:NeuronFarm's 3D-Reader ready to ship 2Sarbox necessitating ECM software, but beware of `best practices' 2Sarbox necessitating ECM software, but beware of `best practices' 3
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Mouse Anti-Human Kallikrein 2 (Hk2)...
Recognizes a full-length CLC-2 voltage-gated Cl- protein and not with other known proteins tested so far....
... Rabbit polyclonal to ErbB 2 ... Abpromise for all tested applications). ... peptide: AENPEYLGLDVPV conjugated to KLH, corresponding ... of Human c-ErbB2 ...
Biology Products: