Navigation Links
VARI study could improve treatments for prostate cancer
Date:4/1/2010

Grand Rapids, Mich. (April 1, 2010) Van Andel Research Institute (VARI) scientists have determined how two proteins required for the initiation and development of prostate cancer interact at the molecular level, which could lead to improved treatments for the disease.

One of the proteins, androgen receptor, is already an important drug target for prostate cancer. The other, steroid receptor coactivator-3 (SRC3), was originally identified for its role in the development of breast cancer. SCR3 has also been characterized as a key factor in the development of prostate cancer, but, until now, the exact relationship between androgen receptor and SCR3 has been unclear.

Understanding the relationship between these two proteins, and targeting this interaction, could lead to new, more effective treatments for prostate cancer, the most common form of cancer in men, with more than 192,000 new cases and more than 27,000 deaths reported in the United States in 2009 (Source: National Cancer Institute).

"Anti-androgen therapies become less effective over time," said VARI Distinguished Scientific Investigator H. Eric Xu, Ph.D., whose laboratory published the findings recently in the Journal of Biological Chemistry, where it was named Paper of the Week by the journal. "To develop the next generation of prostate cancer treatments, we need to find ways to disrupt the interaction between androgen receptor and the molecules it depends on to work, such as SRC3."

Androgen receptor activity is required for the initiation and development of prostate cancer. When activated by hormones, androgen receptor binds to DNA in the cell nucleus and regulates gene expression with the help of molecules called coactivators, including SRC3. As a result, genes create more or less of specific proteins in the cell, which can affect cell behavior. Although androgen receptor needs coactivators such as SRC3 to have an effect, little has been known about pr
'/>"/>

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. LSU researcher receives grant to study equine adult stem cells
2. Grocery shoppers who try harder to track costs do worse, study finds
3. Study uses Chinese wolfberries to improve vision imperfections caused by type-2 diabetes
4. Study shows compulsive eating shares addictive biochemical mechanism with cocaine, heroin abuse
5. Single gene dramatically boosts yield, sweetness in tomato hybrids, CSHL-Israeli study finds
6. Rochester study connects workplace turmoil, stress and obesity
7. Rodeo bull goes head-to-head with zoo dolphins in a study of balance
8. New study may explain how weight-loss surgery reverses type 2 diabetes
9. To close achievement gap, US must address major health risks for urban minority youth, study finds
10. Tectonics: Precision is hallmark of 20-year study
11. Study explores link between sunlight, multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... SAN DIEGO , Dec. 9, 2014 ... and collaboration catalyst that provides the connective tissue that ... by enabling them to easily share client-level information; earned ... Foundation to expand to organizations serving seniors aging in ... San Diego" partner on December 11 th 4-6p. ...
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... 1, 2011 -- Multidrug-resistant Acinetobacter baumannii (MDR-AB) ... the rooms of patients colonized or infected with the ... November issue of the American Journal of Infection ... Association for Professionals in Infection Control and Epidemiology. ...
... A National Institutes of Health (NIH) grant to Los Alamos ... of how many human genes function. Originally discovered in ... human body have been slow to reveal their exact roles. ... function is to take the protein it produces and generate ...
... factors could pit savannas and forests against each other ... to stabilize the two. Without this harmony, the habitats, ... the detriment of the people and animals that rely ... in the journal Science that savanna wildfires, ...
Cached Biology News:Acinetobacter baumannii found growing in nearly half of infected patient rooms 2Antibody library project could unlock mysteries of human gene function 2Savannas, forests in a battle of the biomes, Princeton researchers find 2Savannas, forests in a battle of the biomes, Princeton researchers find 3Savannas, forests in a battle of the biomes, Princeton researchers find 4
(Date:12/24/2014)... and NEW YORK , ... PTBI, PTBIW), a biopharmaceutical company advancing patient care in ... offering of 3,500,000 shares of common stock, and warrants ... common stock, at an offering price of $4.00 per ... per share exercise price of $5.00, are exercisable immediately, ...
(Date:12/24/2014)... Earlier this year in a June 24 international ... Adult Stem Cell Technology Center, LLC ( ASCTC ) ... unique property of adult tissue stem cells. His ... the Past, Important for the Future,” embodied the essence ... the address at the 4th World Congress on Cell ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. George ... Society for Reproductive Medicine (ASRM), a leading professional organization ... In his new role as treasurer, Dr. Hill ... will have a voice in furthering the mission of ... since 1984 when he joined while conducting fellowship training ...
(Date:12/24/2014)... PharmaBoardroom,s new report, , Healthcare and ... free download , digs deep into this vibrant market, ... sector today. One area where Algeria ... a homegrown pharmaceutical manufacturing base, even if the government,s ambitious ... off. A cursory comparison with neighboring Morocco ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... Reportlinker.com announces that a new market ... Biochips: Genosensors, Microarrays, Labs-On-The-Chip ... http://www.reportlinker.com/p0591346/ Biochips-Genosensors-Microarrays-Labs-On-The-Chip .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic Highlights ... and Labs-on-the-Chip are extensions of biosensor and ...
... Researchers at the University of Pittsburgh School of Dental ... biomineralization, which could lead to novel nanoscale approaches to ... in the Proceedings of the National Academy of ... tissue in the body and combines high hardness with ...
... legislation restricts animal testing within the pharmaceutical and cosmetic ... to ensure that their products are safe to use. ... BMC Genomics demonstrates that the response of laboratory ... chemicals as sensitizing, or non-sensitizing, and can even predict ...
Cached Biology Technology:Biochips: Genosensors, Microarrays, Labs-On-The-Chip 2Cell-based alternative to animal testing 2
... years of expertise in the field of ... the most powerful systems on the market. ... 000 in-microplate tests requiring incubation and washing ... modules (such as worktable shaker incubators, reader,washer), ...
... pre-validated SNP sequencing services ... within 93 genes including ... more than 80 tyrosine ... were developed and validated ...
... Mouse anti-Yersinia pestis F1 antigen, ... Applications: ELISA: Use at ... at an assay dependent dilution. WB: ... Predicted molecular weight: 18 kDa. Not ...
... Fixation medium Reagent B - Permeabilisation medium ... cells in suspension with Reagent A and ... This procedure gives antibodies access to intracellular ... of the cells intact. Specific formulations reduce ...
Biology Products: