Navigation Links
VAI researchers develop tool to help study prostate cancer
Date:3/11/2010

Grand Rapids, Mich. (March 11, 2010) Van Andel Research Institute (VARI) researchers have developed a new method to better study the cells that line and protect the prostate in relation to the development of cancer. Using the model, they found that normal cells and cancer cells depend on different factors to survive, which could aid in discovering how to target cancer cells without affecting normal cells when developing treatments.

Prostate cancer is the most common form of cancer in men, with more than 192,000 new cases and more than 27,000 deaths reported in the United States in 2009 (Source: National Cancer Institute).

"This new model will serve as a valuable tool for understanding secretory prostate epithelial cells, which until now have not been available for extensive analysis," said VARI Scientific Investigator Cindy Miranti, Ph.D., whose lab published its study in a recent issue of the Journal of Cell Science.

Epithelial cells line and protect the internal and external organs and structures of the body. The prostate contains two types of epithelial cells, basal and secretory, and prostate cancers arise from abnormal cells as they are converted from basal into secretory cells in the body.

Prior to this study, scientists were able to culture basal cells, but not secretory cells. Using the model, researchers found that, unlike cancer cells, normal secretory cells are not dependent on the male sex hormone androgen for survival, but are dependent for survival on binding to each other via the protein E-cadherin.

"Prostate cancers are dependent on androgen for survival, so we were interested in whether normal secretory prostate epithelial cells also depend on androgen," said Dr. Miranti. "However, the cell culture models available didn't allow us to study secretory cells, so we generated them by reconstructing the natural conversion process from basal into secretory cells in a petri dish."

The differen
'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers examine plants ability to identify, block invading bacteria
2. Community involvement important in fight against childhood obesity, according to UTHealth researchers
3. Exercise counters negative effects of weight regain, researchers find
4. Rice researchers make graphene hybrid
5. New dinosaur rears its head; U-M researchers part of team announcing find
6. Discovery in legumes could reduce fertilizer use, aid environment: Stanford researchers
7. Researchers fishing for cancer cure discover active DHA derivatives
8. Researchers determine how ATP, molecule bearing the fuel of life, is broken down in cells
9. NOAA, NASA and Old Dominion researchers measure impacts of changing climate on ocean biology
10. Researchers issue outlook for a significant New England red tide in 2010
11. French and Spanish researchers develop a natural alternative to antibiotics in animal feed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... FL, July 10, 2014 Amidst the astounding complexity ... synaptic connections in the brain, how do nerve cells ... to build? How do they coordinate these events within ... from the Florida campus of The Scripps Research Institute ... showing that a particular protein plays a far more ...
(Date:7/10/2014)... CORVALLIS, Ore. Nuclear engineers at Oregon State University ... detection device that should help people all over the ... and intensity, and whether or not it poses a ... due to public demand following the nuclear incident in ... unsure what level of radiation they were being exposed ...
(Date:7/10/2014)... partners predict that western Lake Erie will have a ... the 2014 bloom season in late summer. However, the ... year,s intense bloom, and considerably less than the record-setting ... lake,s western basin and are classified by an estimate ... , Harmful algal blooms (HABs) were common in ...
Breaking Biology News(10 mins):Scripps Florida scientists shed new light on nerve cell growth 2Sophisticated radiation detector designed for broad public use 2Sophisticated radiation detector designed for broad public use 3NOAA, partners predict significant harmful algal bloom in western Lake Erie this summer 2NOAA, partners predict significant harmful algal bloom in western Lake Erie this summer 3
... new chemical analysis technique developed by a research group ... uses the shifting ultrasonic pitch of a small quartz ... micrograms of material. Since it works with samples close ... the new technique should be an important addition to ...
... cancer patients have tumours that show rapid growth and ... of these cases is the presence of a large ... these aggressive tumours are referred to as HER2+. Scientists ... headed by ICREA researcher Roger Gomis, have described the ...
... CHAMPAIGN, Ill. The long, anxious wait for biopsy ... technique developed at the University of Illinois. The ... interferometric vibrational imaging (NIVI), on rat breast-cancer cells and ... clear tumor boundaries, with more than 99 percent confidence ...
Cached Biology News:Quartz crystal microbalances enable new microscale analytic technique 2The most aggressive forms of breast cancer elude cellular control mechanisms in order to expand 2New imaging technique accurately finds cancer cells, fast 2New imaging technique accurately finds cancer cells, fast 3
(Date:7/10/2014)... Calabasas, CA (PRWEB) July 10, 2014 ... academic institutions and professional associations, addressed the challenges of ... & Medical Device Industries” through strategic sourcing. Describing the ... ) with the Supply Chain Management Institute ( SCMI) ... the event on June 24 at the Kroc Institute ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
(Date:7/10/2014)... in the fight against terrorism with the creation of ... with the use of light and special glass fibres. ... B: Chemical , the researchers describe a novel optical ... low as 6.3 ppm (parts per million). It requires ... "Traditionally explosives detection has involved looking for metals that ...
(Date:7/10/2014)... observed the fractional quantum Hall effect in bilayer graphene ... be tuned by an electric field. , The ... confined to thin sheets are exposed to large magnetic ... thousands of individual electrons behave as a single system. ... well established, many details of this collective behavior remain ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... availability of Stock Alerts on stocks making news today. As ... up the charts. So how does swine flu affect the ... AVII, DVAX) reeling from influenza news that should be on ... Stock Alerts include: Hemispherx Biopharma Inc. ...
... also referred to as ,Mini IVF, or ,Minimal Stimulation ... reproductive endocrinologists are now weighing in at ... "Micro IVF," also called "Mini IVF" or "Minimal Stimulation ... social network providing 24-7-365 support on fertility matters, connecting ...
... Inc. (NYSE Amex: PIP ), a biodefense ... announced today that results from a second Phase II ... Annual Conference on Vaccine Research, being held in Baltimore, ... the National Foundation of Infectious Diseases.David P. Wright, President ...
Cached Biology Technology:Antiviral Drugmaker Shares Soar as Swine Flu Spreads; Beacon Equity Issues Stock Alerts on: HEB, GNBT, BCRX, DVAX, NVAX, SVA 2Antiviral Drugmaker Shares Soar as Swine Flu Spreads; Beacon Equity Issues Stock Alerts on: HEB, GNBT, BCRX, DVAX, NVAX, SVA 3Under the Microscope: 'Micro IVF' 2Under the Microscope: 'Micro IVF' 3PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research 2PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research 3PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research 4PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research 5PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research 6PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research 7
... xi multi-cell is for 2-D separations. The cell ... The PROTEAN II xi multi-cell can be customized ... glass plates, and cooling system. The PROTEAN II ... PROTEAN II XL multi-cell for a wider format ...
... The PROTEAN II xi cell, 16 cm, is ... acids and proteins in agarose gels. The cell ... includes a central cooling core with gaskets, lower ... glass plates, 4 sandwich clamps, upper buffer dam, ...
CleanCut agarose is used to prepare genomic DNA plugs for use in pulsed field gel electrophoresis (PFGE) applications. Supplied as a 12 ml solution of 2% agarose....
...
Biology Products: