Navigation Links
Using planarian flatworms to understand organ regeneration
Date:10/25/2012

CHAMPAIGN, Ill. Researchers report in the journal Developmental Cell that they have identified genes that control growth and regeneration of the intestine in the freshwater planarian Schmidtea mediterranea.

"How animals repair their internal organs after injury is not well understood," said University of Illinois cell and developmental biology professor Phillip Newmark, who led the study. "Planarian flatworms are useful models for studying this question."

After injury, planaria are able to re-grow missing body parts, including any organs that are damaged or lost, such as brain, eyes, and intestine. Injury initiates a complex set of cellular events, Newmark said. In planarians, specialized non-reproductive stem cells called neoblasts divide and give rise to all of the different cell types required to rebuild fully functional body parts. Old tissue remaining after amputation remodels and integrates with the new cells.

"The molecular signaling pathways that coordinate these cellular events to achieve organ regeneration have not been well characterized," Newmark said.

David Forsthoefel, a postdoctoral researcher in Newmark's laboratory and the lead author on the study, wanted to address the problem using the planarian intestine as a "model organ," in part because so few animals are capable of repairing severe damage to their digestive systems.

"The ability to recover from loss of digestive tissue is rare in the animal kingdom," Forsthoefel said. "What we learn from how a simple worm deals with gut damage might one day help us to come up with better medical therapies, for example in the treatment of short bowel syndrome, in which segments of intestine must be removed from patients with digestive diseases, leading to impaired nutrient absorption."

Forsthoefel developed a method for purifying a single intestinal cell type from the planarian gut. He and his colleagues in the Newmark lab identif
'/>"/>

Contact: Phillip Newmark, Professor of Cell and Developmental Biology
pnewmark@life.illinois.edu
217-244-4674
School of Molecular and Cellular Biology, University of Illinois, Urbana
Source:Eurekalert  

Page: 1 2

Related biology news :

1. The slippery slope to slime: Overgrown algae causing coral reef declines
2. App lets you monitor lung health using only a smartphone
3. Deep-sea crabs seek food using ultraviolet vision
4. New study shows promise in using RNA nanotechnology to treat cancers and viral infections
5. NIH-funded researchers restore sense of smell in mice using genetic technique
6. Researchers identify key culprit causing muscle atrophy
7. Using millions of years of cell evolution in the fight against cancer
8. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
9. Using wastewater as fertilizer
10. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
11. Real-life spider men using protein found in venom to develop muscular dystrophy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using planarian flatworms to understand organ regeneration
(Date:7/11/2014)... A new report from the Wildlife Conservation Society ... only help economically valuable species such as lobster, ... also help re-colonize nearby reef areas. , The ... a systematic review of research literature from no-take ... by Dr. Craig Dahlgren, a recognized expert in ...
(Date:7/11/2014)... Mills Canyon fire started near the City of Entiat ... local resources, the fire quickly grew to over 1,000 ... of the fire is under investigation by the Washington ... working with existing local resources in developing fire control ... Service (USFS), Washington State Department of Natural Resources, (WA ...
(Date:7/11/2014)... available in German . ... that uses the refraction of X-rays through a specimen ... with this method are often of much higher quality ... team of Prof. Franz Pfeiffer are particularly interested in ... including X-ray phase-contrast imaging. One main goal is ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2New simple setup for X-ray phase contrast 2
... the planet. They thrive in almost every known environment, ... that provide the capabilities essential for survival. These genetic ... mutation and exchange of genes and other bits of ... which then becomes an intrinsic part of the genome. ...
... URBANA - When University of Illinois researchers surveyed over 3,500 ... accurately, and overweight and obese men were more likely to ... because the first step in dealing with a weight problem ... U of I professor of food science and human nutrition. ...
... Most medical imaging equipment is not designed with overweight and ... be exposed to higher levels of radiation during routine X-ray ... Polytechnic Institute is the first to calculate exactly how much ... results show the internal organs of obese men receive 62 ...
Cached Biology News:Study shows unified process of evolution in bacteria and sexual eukaryotes 2Study shows unified process of evolution in bacteria and sexual eukaryotes 3Misperception of weight is an important barrier to weight loss 2Obese patients face higher radiation exposure from CT scans -- but new technology can help 2
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... Adelaide research may help in the fight against terrorism ... tiny quantities of explosives with the use of light ... Sensors and Actuators B: Chemical , the researchers ... explosives in concentrations as low as 6.3 ppm (parts ... a few minutes. , "Traditionally explosives detection has involved ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... - NovaScan, an early-stage medical imaging company developing what ... of breast cancer, had to bypass angel tax credits from ... for its emerging technology. , ,The company instead has raised ... a state loan, and grants. , ,According to CEO Larry ...
... rural Wisconsin, one company is earning their bread and ... Networks, Inc. , a global satellite communications provider, has ... , a satellite-based broadband access provider. , ,IsoTropic operates ... set on 21 acres in rural Wisconsin, and it ...
... Last week, the nation marked the five-year anniversary of ... restrictions have unquestionably set back the progress of this ... Congress passed legislation that would have lifted President Bush's ... ones are suffering from a wide range of debilitating ...
Cached Biology Technology:NovaScan decides against tax credits 2Rural company works to improve broadband 2Stem cell research holds the promise for tomorrow 2Stem cell research holds the promise for tomorrow 3
... is the only PCR system that ensures ... time. It provides accuracy, consistency, and dependability ... the property of the DNA templates. This ... a unique blend of thermostable enzymes that ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... to meet the needs of ... component-free medium supports fast cell ... densities, while maintaining high cell ... production using the Baculovirus Expression ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: