Navigation Links
Using planarian flatworms to understand organ regeneration
Date:10/25/2012

CHAMPAIGN, Ill. Researchers report in the journal Developmental Cell that they have identified genes that control growth and regeneration of the intestine in the freshwater planarian Schmidtea mediterranea.

"How animals repair their internal organs after injury is not well understood," said University of Illinois cell and developmental biology professor Phillip Newmark, who led the study. "Planarian flatworms are useful models for studying this question."

After injury, planaria are able to re-grow missing body parts, including any organs that are damaged or lost, such as brain, eyes, and intestine. Injury initiates a complex set of cellular events, Newmark said. In planarians, specialized non-reproductive stem cells called neoblasts divide and give rise to all of the different cell types required to rebuild fully functional body parts. Old tissue remaining after amputation remodels and integrates with the new cells.

"The molecular signaling pathways that coordinate these cellular events to achieve organ regeneration have not been well characterized," Newmark said.

David Forsthoefel, a postdoctoral researcher in Newmark's laboratory and the lead author on the study, wanted to address the problem using the planarian intestine as a "model organ," in part because so few animals are capable of repairing severe damage to their digestive systems.

"The ability to recover from loss of digestive tissue is rare in the animal kingdom," Forsthoefel said. "What we learn from how a simple worm deals with gut damage might one day help us to come up with better medical therapies, for example in the treatment of short bowel syndrome, in which segments of intestine must be removed from patients with digestive diseases, leading to impaired nutrient absorption."

Forsthoefel developed a method for purifying a single intestinal cell type from the planarian gut. He and his colleagues in the Newmark lab identif
'/>"/>

Contact: Phillip Newmark, Professor of Cell and Developmental Biology
pnewmark@life.illinois.edu
217-244-4674
School of Molecular and Cellular Biology, University of Illinois, Urbana
Source:Eurekalert  

Page: 1 2

Related biology news :

1. The slippery slope to slime: Overgrown algae causing coral reef declines
2. App lets you monitor lung health using only a smartphone
3. Deep-sea crabs seek food using ultraviolet vision
4. New study shows promise in using RNA nanotechnology to treat cancers and viral infections
5. NIH-funded researchers restore sense of smell in mice using genetic technique
6. Researchers identify key culprit causing muscle atrophy
7. Using millions of years of cell evolution in the fight against cancer
8. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
9. Using wastewater as fertilizer
10. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
11. Real-life spider men using protein found in venom to develop muscular dystrophy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using planarian flatworms to understand organ regeneration
(Date:9/11/2014)... professor of mechanical engineering at Worcester Polytechnic ... university,s Integrative Materials Design Center (iMdc), has ... National Science Foundation (NSF) to support the ... metal-ceramic composites, which can be used to ... while significantly increasing their performance. , The ...
(Date:9/11/2014)... 11, 2014 UT Southwestern Medical Center, 2M Companies, ... research and drug development for neurodegenerative disorders caused by ... week, UT Southwestern researchers published a new paper about ... has been shown to help in various animal models ... to Dallas-based 2M Companies. 2M and Calico have now ...
(Date:9/11/2014)... In a study that sheds light on the ... of South America, LSU Museum of Natural Science Director ... Biological Sciences, Robb Brumfield, and an international team of ... published a paper this week challenging the view that ... formed is directly linked to geological and climatic ...
Breaking Biology News(10 mins):NSF funds new method for making materials that can make lighter, more efficient vehicles 2NSF funds new method for making materials that can make lighter, more efficient vehicles 3Calico enters into exclusive collaboration with 2M to develop UTSW technology 2Calico enters into exclusive collaboration with 2M to develop UTSW technology 3LSU scientists lead research on speciation in the tropics 2
... Ivaska (University of Turku and VTT Technical Research Centre of ... National Institute for Health and Welfare) have discovered that the ... a leading journal, the study concludes that SHARPIN regulates the ... prostate cancer cells. It is likely that the discovery will ...
... risk of extinction is a complicated task, especially for species ... University of Georgia and Tulane University have developed a mathematical ... appears in the early online edition of the Royal Society ... for a lot of species, we don,t know very much ...
... might lead to the development of better intervention methods, according ... published in the journal Substance Use & Misuse ... prompted college students to recall their smoking experience, and that ... and on weekends. "Students are using social events ...
Cached Biology News:New model more accurately describes migratory animals' extinction risk 2Research reveals when and why students smoke in effort to help them quit 2
(Date:9/11/2014)... Frederick, MD (PRWEB) September 12, 2014 ... systems (LIMS), radio-frequency identification (RFID) solutions and sample ... version 5.1. , RURO completed work on the ... late August and it has already seen mass ... recent major release of version 5.0 brought an ...
(Date:9/11/2014)... team of Berkeley Lab researchers believes it has ... of single atomic layers of transition metal dichalcogenide ... promise for nanoelectronic and photonic applications. , ... of tungsten disulfide, one of the most promising ... existence of excitonic dark states energy states ...
(Date:9/11/2014)... surface of graphene, a one atom thick sheet of ... graphene oxide; a form of graphene that could have ... industries. Applied as paint, it could provide an ultra-strong, ... , Graphene oxide solutions can be used to ... even conventional bricks. After a simple chemical treatment, the ...
(Date:9/11/2014)... Sept. 11, 2014 XBiotech announced today it ... machine that the Company says will be used to ... system is designed to fill, stopper and crimp vials, ... Additionally, the unit is said to contain an in-line ... provide a high level of quality compared to less ...
Breaking Biology Technology:Limfinity® Version 5.1 Available 2Excitonic dark states shed light on TMDC atomic layers 2Excitonic dark states shed light on TMDC atomic layers 3Graphene paints a corrosion-free future 2
... Press Ganey Associates, Inc. has announced its elite class ... the first-ever Summit and Top Improver awards for clinical ... Medical Centers. Press Ganey, the health ... more than 10,000 health care organizations worldwide to create ...
... Calif., Nov. 15, 2011 Quest Diagnostics Incorporated (NYSE: ... diagnostic testing, information and services, today announced that its ... Cytomegalovirus (CMV) molecular test kit on the 3M™ Integrated ... The test is designed to enable hospital labs to ...
... AURORA, Colo., Nov. 15, 2011 In a strategic ... Redevelopment Authority (FRA) has completed a regimen of planning ... allocation of resources going forward. The announcement is made ... "Our first tactic in refocus involves augmenting our board ...
Cached Biology Technology:Nation's Best Health Care Organizations for Patient Satisfaction, Core Measures Honored by Press Ganey 2Nation's Best Health Care Organizations for Patient Satisfaction, Core Measures Honored by Press Ganey 3Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 2Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 3Fitzsimons Redevelopment Authority Rolls Out First Phase of Strategic Refocus With Appointment of Four Key Leaders in The Bioscience Industry to Its Board of Directors 2
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from frozen ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... coated slides. Sections are large (3-5mm in ...
... The DNA Engine Opticon real-time PCR detection ... for fluorescence excitation (450-495 nm) and a ... The Opticon system is built on an ... a thermal gradient feature. This item includes ...
... for Optimal Microdissection , CapSure HS and ... and rapid extraction of populations of pure ... with Laser Capture Microdissection., Ensure the ... Analysis , All CapSure LCM Caps have ...
Biology Products: