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Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
Date:11/12/2013

ed with morphine for a week after the surgery took four weeks to recover from the postoperative pain compared with two weeks among the control group of rats.

"We're seeing the pain prolong for weeks after the discontinuation of morphine," Grace said.

The research team also tested the effects of the drug (+)-naloxone, which inhibits morphine from binding to the glial cells and exciting them. They found that the use of (+)-naloxone along with the morphine eliminated the extended postoperative pain effect.

The researchers are now studying in more detail how morphine excites glial cells and how (+)-naloxone works to block that process. A better understanding of that pathway in the brain may help researchers find a wider variety of drugs that could be administered along with morphine in the future to limit postoperative pain.


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Contact: Peter Grace
Peter.Grace@colorado.edu
University of Colorado at Boulder
Source:Eurekalert

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