Navigation Links
Using high-precision laser tweezers to juggle cells
Date:5/15/2009

Researchers at the University of Gothenburg, Sweden, have developed a new method to study single cells while exposing them to controlled environmental changes. The unique method, where a set of laser tweezers move the cell around in a microscopic channel system, allows the researchers to study how single cells react to stress induced by a constantly changing environment.

Studies on how cells react to changes in their environment, such as reduced availability of nutrients, have traditionally used cultures consisting of millions of cells. While such studies show how cells on average react to a new environment, they say nothing about individual variation, for example how quickly a single cell responds.

PhD Emma Eriksson and her colleagues at the Department of Physics, University of Gothenburg, Sweden, developed a method where laser tweezers are used to catch a cell the size of about one micrometer, or 0.001 of a mm, and then move the cell between different environments.

Placing the cell in a system of channels made of silicone, in which each channel is finer than a human hair, enables the researchers to add and remove substances so that the environment surrounding a single cell changes in a split second - while at the same time watching the reactions through a microscope.

The channels in the so-called microfluidic system can be likened to tiny water pipes. In a channel, a single cell can be exposed to tests and various substances for very exact time periods, which enables the researchers to repeatedly add and remove a substance to see how it affects the behaviour of the cell. This new method gives researchers information that would not be possible to obtain with traditional methods.

In its first stage, the new method has been tested on yeast cells. One of the cells' proteins was tagged with a green fluorescent protein (GFP), enabling researchers to trace the movements of the protein within the cell while it adjusts to a new environment.

'The method can be used to reveal how a cell reacts to stress induced by a change in its environment. The information gained from this may eventually lead to a better understanding of how cells work and what they do to stay alive and healthy in a constantly changing environment', says Eriksson.


'/>"/>

Contact: Krister Svahn
krister.svahn@science.gu.se
46-031-786-4912
University of Gothenburg
Source:Eurekalert  

Related biology news :

1. Consumers more likely to identify healthy food using traffic light nutrition labels
2. Using combinatorial libraries to engineer genetic circuits advances synthetic biology
3. K-State using Second Life island to help high school students learn earth science
4. Caltech scientists control complex nucleation processes using DNA origami seeds
5. VeriLook Surveillance SDK Provides Real-Time Face Identification Using Video Surveillance Cameras
6. VeriLook Surveillance SDK Provides Real-Time Face Identification Using Video Surveillance Cameras
7. Using hair to manage HIV/AIDS and predict treatment success
8. Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
9. MIT: Using touch to help deaf people
10. Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test
11. Biological control of tropical weeds using arthropods
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using high-precision laser tweezers to juggle cells
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... USA (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s ... take place on 7th and 8th June 2018 in San Francisco, CA. The Summit ... as well as several distinguished CEOs, board directors and government officials from around the ...
Breaking Biology Technology: