Navigation Links
Using hair to manage HIV/AIDS and predict treatment success
Date:3/3/2009

UCSF researchers have found that examining levels of antiretroviral drugs in hair samples taken from HIV patients on therapy strongly predicts treatment success.

The findings, published in the February 20 issue of AIDS, note that the levels of antiretrovirals found in the hair of patients on treatment correlated strongly with levels of HIV virus circulating in patients' blood.

"High levels of antiretrovirals in hair correlated with success in HIV viral suppression in treatment and did so better than any of the other variables usually considered to predict response," said the study's primary investigator, Monica Gandhi, MD MPH, assistant professor of medicine at UCSF's Positive Health Program at San Francisco General Hospital.

Typically, clinicians rely on either self-report by patients, pill counts or expensive medication dispensing devices to monitor how well patients are taking their pills as directed. These methods are highly patient dependent and have not been good predictors of treatment success.

Clinicians can draw blood and then measure plasma levels of medications, but since a single plasma level represents medication exposure only hours prior to the blood draw, this method has also not been a good predictor of viral suppression, according to Gandhi. Single drug levels can vary day-by-day for a single patient and may reflect improved pill-taking by patients just before clinic visits, she said.

Hair, which grows at a rate of about a centimeter a month, gives a reading of drug levels that reflects the rate of pill consumption sustained by patients over weeks, not days. Assessing an average level of drug exposure over time may be more predictive of treatment response than the "snapshot" of exposure provided by a single plasma level of medication, Gandhi said.

"Hair sampling for antiretroviral levels could become a new standard to look at how much drug a patient is gettingan equivalent in
'/>"/>

Contact: Jeff Sheehy
jsheehy@ari.ucsf.edu
415-597-8165
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
2. MIT: Using touch to help deaf people
3. Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test
4. Biological control of tropical weeds using arthropods
5. Defying the disaster: Researcher explores resilient housing
6. Link between unexploded munitions in oceans and cancer-causing toxins determined
7. Singapore research organisations team up to advance drug discovery using brain tumor stem cells
8. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
9. Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family
10. Cancer-causing gene discovery suggests new therapies
11. Warmer climate causing huge increase in tree mortality across the West
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... be cultivated efficiently, they are anything but sustainable: ... monoculture cultivation is becoming increasingly evident. Despite their ... and are regarded as the sole possibility of ... wrongfully, finds Bernhard Schmid, an ecology professor at ... form of agriculture and forestry. After all, a ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market releases photos and ... Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. Verdi ... CEO of NXT-ID thanked his investors and employees "for their work ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... they get rid of excess energy through the production of hydrogen. ... notice the absence of oxygen. For this, they need the messenger ... from red blood cells of humans. With colleagues at the UC ... ". Haemoglobin an old protein in a new ...
... human genome more readily in tumors than in normal ... University of Maryland School of Medicine,s Institute for Genome ... Human Genome Project, the 1,000 Genomes Project and The ... lateral gene transfer (LGT), the transmission of genetic material ...
... of the esteemed Cubist-ICAAC Award is George L. ... University of Florida, for his application of pharmacokinetic ... development. According to his nominator, Michael Dudley, Rempex ... work using pharmacokinetics/pharmacodynamics to simulate and then validate ...
Cached Biology News:When green algae run out of air 2Bacterial DNA may integrate into human genome more readily in tumor tissue 2The American Society for Microbiology honors George L. Drusano 2
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
(Date:10/19/2014)... The Latin American hardware encryption display market report defines ... and forecast of revenue. This market was valued at ... $2,366.8 million by 2018, at a CAGR of 70.3% ... of the Latin American hardware encryption market report to ... also provides a glimpse of the segmentation of the ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific Speech ... market in Asia-Pacific with analysis and forecast of revenue. ... in 2014 to $208 million by 2019, at a ... to 2019. , Browse through the TOC of the ... of the in-depth analysis provided. It also provides a ...
(Date:10/18/2014)... October 19, 2014 The “Human ... Acting, Intermediate Acting, Premixed), Modern Human Insulin (Rapid ... Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast to ... drivers, restraints, challenges, opportunities, current market trends, and ... with the estimates and forecasts of the revenue ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... The following statement was issued today by the law firm of Barroway ... Notice is hereby given that a class action lawsuit was filed ... York on behalf of purchasers of the securities of Elan Corporation, plc ... 2007 and October 21, 2008, inclusive (the "Class Period"). , ...
... Dec. 11 Myngle,( http://www.myngle.com ), the global ... ICT company at the Europe Unlimited,s European Venture ... EVS is a showcase for ... and new energy entrepreneurs from all over Europe ...
... and ST. PAUL, Minn., Dec. 11 The University ... research from the,Richard M. Schulze Family Foundation. Goals for ... on the University,s strength in diabetes,research and to accelerate the ... type 1 diabetes. , ...
Cached Biology Technology:Shareholder Class Action Filed Against Elan Corporation, plc by the Law Firm of Barroway Topaz Kessler Meltzer & Check, LLP 2Myngle Best ICT Company at the European Ventures Summit 2University of Minnesota Receives $40 Million for Type 1 Diabetes Research 2University of Minnesota Receives $40 Million for Type 1 Diabetes Research 3University of Minnesota Receives $40 Million for Type 1 Diabetes Research 4