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Using green chemistry to deliver cutting-edge drugs
Date:9/13/2007

rates within the body and therefore polymer selection can be tailored to achieve desired release rates.

Thus the process allows for gradual, controlled release of a drug, reducing side effects and improving quality of life. For the patient, it could mean the end of twice-daily injections in favour of an injection once a week.

Drug encapsulation techniques using green chemistry techniques are currently in advanced tests at spin-out company Critical Pharmaceuticals Ltd. set up in 2002 by Prof Howdle and colleagues and expected to proceed to clinical trials soon. Since the drugs and polymers being used have already been approved separately, the process is likely to be available for patients sooner than might otherwise be expected with an entirely untested process.

As well as new methods of drug delivery, the use of supercritical fluids offers cleaner, residue-free processes that can be harnessed to produce other new polymer materials ranging from enhanced bullet proof plastics through to detergents and coatings and even porous scaffolds for tissue engineering.


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Contact: Professor Steve Howdle
steve.howdle@nottingham.ac.uk
University of Nottingham
Source:Eurekalert

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